Isolation, biological activity, and synthesis of isoquinoline alkaloids

Yang, Xiaorong; Miao, Xiaolou; Dai, Lixia; Guo, Xiao; Jenis, Janar; Zhang, Jiyu; Shang, Xiaofei

doi:10.1039/d4np00023d

Nat. Prod. Rep.

2024

DOI: 10.1039/d4np00023d

|View full text |Cite

Isolation, biological activity, and synthesis of isoquinoline alkaloids

Xiaorong Yang,

Xiaolou Miao,

Lixia Dai

et al.

Abstract: Isoquinoline alkaloids are common throughout living organisms and exhibit widely bioactivities

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Preprint1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 250 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Remarkable diversity of alkaloid scaffolds inPiper fimbriulatum

Damiani,

Smith,

Hebra

et al. 2024

Preprint

View full text Add to dashboard Cite

SummaryThe Piperaceae plant family is known for its special phytochemistry and is widely recognized as a rich source of bioactive natural products. Piperaceae plants, especially from thePipergenus, have been extensively investigated in the past decades; yet, new alkaloids are still regularly reported from this genus. Here, we investigated the alkaloid diversity ofPiper fimbriulatumusing a metabolomics workflow that combines untargeted LC-MS/MS analysis with a range of recently developed computational tools. In particular, we leverage open libraries of MS/MS spectra and metabolomics data repositories for metabolite annotation and to direct isolation efforts towards structurally-novel compounds (i.e., dereplication). We identified several alkaloids belonging to 5 different classes and isolated one novelseco- benzylisoquinoline alkaloid with a linear quaternary amine nitrogen. Notably, many of the identified compounds were never reported in Piperaceae plants. Our findings expand the known alkaloid diversity of the Piperaceae family, and demonstrate the potential of revisiting well-studied plant families using state-of-the-art computational metabolomics workflows to uncover previously overlooked chemodiversity. Finally, we contextualized our findings in a broader evolutionary framework by mapping literature reports for the identified alkaloid scaffolds onto the angiosperm tree of life, which highlighted the remarkable alkaloid diversity in thePipergenus.Significance StatementWe leveraged untargeted metabolomics with a range of recently developed computational tools to uncover a remarkable diversity of alkaloid scaffolds inPiper fimbriulatum. Our findings demonstrate the potential of revisiting well-studied plant families using state-of-the-art computational metabolomics workflows to uncover previously overlooked chemodiversity.

show abstract

Remarkable diversity of alkaloid scaffolds inPiper fimbriulatum

Damiani,

Smith,

Hebra

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Isolation, biological activity, and synthesis of isoquinoline alkaloids

Abstract: Isoquinoline alkaloids are common throughout living organisms and exhibit widely bioactivities

Cited by 1 publication

References 250 publications

Remarkable diversity of alkaloid scaffolds inPiper fimbriulatum

Remarkable diversity of alkaloid scaffolds inPiper fimbriulatum

Contact Info

Product

Resources

About