Isolation, Characterization and Docking Studies of Isolated Compounds as Antidiabetic Molecules from Scindapsus officinalis (Roxb)

Abstract

Natural products are essential to human life, and about half of the medications used in clinical practice today are of natural origin. The present work investigated to isolate and identify active compounds with anti-diabetic activity from Scindapsus officinalis fruits and confirm the isolated compounds' mode of action, affinity, and domain specificity relationships. Some fractions of S. officinalis ethanolic extracts were subjected to column chromatography and preparative TLC and two compounds namely 2E,4E,6E)-5-methyl-7-(2,6,6-trimethylcyclohexa-2,4-dien-1-yl)hepta-2,4,6-trien-1-ol (CN-501A) and 9-(furan-3-yl)-4-hydroxy-1,5,6,6a,9,10,10a,10b-octahydro-3H,7H-pyrano[3,4-f]isochromene-3,7-dione (CN-501B) were isolated in pure form. The structures of the isolated compounds were confirmed by UV, IR, 1H NMR and mass spectral data. The anti diabetic activity was measured using a molecular docking study and the three-dimensional structure of the target protein was downloaded from PDB. The Docking study recommended that CN – 501A and CN – 501B are existing photochemical from the plant of S. officinalis had the highest fitness docking score and hence could be a possible antidiabetic drug.