Isolation, Characterization, Modification of Artocarpin Compound from Pudau Plant (Artocarpus kemando Miq.) and Bioactivity Antibacterial Assay of Artocarpin Compound and Their Modification Result

Sa’diah, Khalimatus; Yuwono, Suripto Dwi; Qudus, Hardoko Insan; Yandri,; Suhartati, Tati

doi:10.1088/1755-1315/537/1/012047

Cited by 3 publications

(7 citation statements)

References 10 publications

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“…Furthermore, the inhibitory effects of cathepsin K have also been described by other workers [22,23]. One of the plants from which flavonoid compounds have been isolated by many workers is A. kemando Miq [13,14,[24][25][26][27], and it has been reported that in many cases, the flavonoids from this plant were found to exhibit positive bioactivity. Another plant reported to contain flavonoids with useful biological activities is Artocarpus.…”

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confidence: 65%

“…The modified artocarpin was confirmed by physical properties, UV-Vis measurement, and FTIR characterization. The compound was also found to exhibit antibacterial activity against Bacillus subtilis and Escherichia coli [25]. As a continuation of the previous study, in this work the modified artocarpin compound was further characterized using NMR and MS techniques, followed by the determination of the anticancer cytotoxicity of the compound against leukemia P-388 cancer cells.…”

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confidence: 72%

“…The results of the work by Sakao & Hou [37] indicated that, when compared to the parent compound, the modified flavonoid by acylation displayed higher antioxidant activity, anti-inflammatory activity, cytoprotective impact, and the potential to trigger apoptosis in cancer cells [37]. In our previous investigation [25], successful modification of artocarpin using acetic anhydride was achieved. The modified artocarpin was confirmed by physical properties, UV-Vis measurement, and FTIR characterization.…”

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confidence: 95%

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Anticancer Activity Study of Modified Artocarpin Compound from Pudau Plant (Artocarpus kemando Miq.)

et al. 2023

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This research is a continuation of the successful isolation of artocarpin from the root of Artocarpus kemando Miq reported in our previous study. In the previous study, the artocarpin was characterized with UV-Vis and FTIR techniques. In this follow-up investigation, the artocarpin was subjected to a transesterification reaction using acetic anhydride and pyridine as catalysts, and the product of the reaction was specified as compound 1. The compound 1 was further characterized with different techniques to gain more complete data and then tested for anticancer activity test against P-388 murine leukemia cells. Characterizations of the compound 1 using 1H-NMR and 13C-NMR techniques suggest that the modification reaction resulted in the conversion of the -OH groups at C2' and 4' at the artocarpin molecule to -OOCH3, and based on the MS analysis, the compound was proposed to have the molecular formula of C30H32O8. Another important feature of compound 1 that should be noted is the significant improvement in stability compared to the unmodified artocarpin. Anticancer activity tests against P-388 murine leukemia cells revealed that compound 1 has an IC50of 2.35 g/mL, confirming that the compound is categorized as an active anticancer agent and suggesting that the compound has promising potential that deserves further investigations. Doi: 10.28991/ESJ-2023-07-03-05 Full Text: PDF

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confidence: 65%

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confidence: 72%

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Anticancer Activity Study of Modified Artocarpin Compound from Pudau Plant (Artocarpus kemando Miq.)

et al. 2023

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“…antibacterial [12], antiplatelet [13], antifungal [14], antimalarial [15], anti-aging [16], and cytotoxic [17].…”

Section: Introductionmentioning

confidence: 99%

“…Artocarpin compounds are flavonoids found in breadfruit plants. Artocarpin is a flavone compound that is often found in Artocarpus plants which contain prenyl groups at C-3 and C-6 [12]. Artocarpin has a hydroxyl group that can undergo oxidation within a certain time, thereby reducing the stability of the compound.…”

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confidence: 99%

Activity Screening and Structure Modification of Artocarpin Against Ace2 and Main Protease Through in Silico Method

et al. 2021

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Objective: SARS-CoV-2 is a type of coronavirus that causes COVID-19 disease. Currently, the right and effective drug for the treatment of COVID-19 has not been found. Artocarpin in the breadfruit plant (Artocarpus altilis), which was tested, has been shown to have antiviral activity. However, artocarpin has a hydroxyl group that can undergo oxidation within a certain time, thereby reducing the stability of the compound and non-specific antiviral activity. Methods: In this study, the structural modification of artocarpin was carried out to obtain compounds with anticoronavirus activity with good physicochemical properties. This research was conducted in silico, including molecular docking simulation, bioavailability prediction, and preADMET. Results: The top 20 modified compounds were selected from each target's top 3 compounds, which had better bond energies compared to the positive control. These 3 compounds have the potential to inhibit ACE2 and Mpro receptors and 1 compound are better at inhibiting both. Conclusion: From the results of the research conducted, we conclude that the 3 best compounds can be potential candidates that can be developed as COVID-19 therapy.

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Antidiabetic and antibacterial activities of artocarpin: a flavonoid compound isolated from the root wood of the Pudau plant (Artocarpus kemando Miq.)

Suhartati,

Irawan,

Ropingi

et al. 2024

Pure and Applied Chemistry

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In this study, artocarpin compound was successfully isolated from the root wood of the Pudau plant (Artocarpus kemando Miq.) and subsequently tested as antidiabetic and antibacterial agent against Staphylococcus aureus and Salmonella typhi. The procedure applied for isolation involved maceration using methanol followed by partition and purification using column chromatography. The purity of the compound was determined using thin layer chromatography and melting point measurement. The compound was subsequently characterized via UV–vis and IR spectroscopy. The compound isolated was obtained as a yellow amorphous solid and has melting point of 168.7–173.6 °C. The antidiabetic tests were performed against α-amylase enzyme, using the compound with the concentrations of 250, 500, 750, and 1000 ppm. The highest inhibition percentage of 43.33 ± 0.02 % was achieved with the use of 750 ppm of the compound and the IC50 value is 32 661.08 ppm. Antibacterial tests were performed with concentration variations of 0.3, 0.4, and 0.5 mg/disc. S. aureus and S. typhi bacteria showed high inhibition at a concentration of 0.5 mg/disc with inhibition zone diameters of 8 and 7 mm, respectively (moderate category).

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Isolation, Characterization, Modification of Artocarpin Compound from Pudau Plant (Artocarpus kemando Miq.) and Bioactivity Antibacterial Assay of Artocarpin Compound and Their Modification Result

Cited by 3 publications

References 10 publications

Anticancer Activity Study of Modified Artocarpin Compound from Pudau Plant (Artocarpus kemando Miq.)

Anticancer Activity Study of Modified Artocarpin Compound from Pudau Plant (Artocarpus kemando Miq.)

Activity Screening and Structure Modification of Artocarpin Against Ace2 and Main Protease Through in Silico Method

Antidiabetic and antibacterial activities of artocarpin: a flavonoid compound isolated from the root wood of the Pudau plant (Artocarpus kemando Miq.)

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