Isolation, Cytotoxicity Evaluation and HPLC-Quantification of the Chemical Constituents from Prangos pabularia

Farooq, Saleem; Shakeel-u-Rehman,; Dangroo, Nisar A.; Priya, Dev; Banday, Javid A.; Sangwan, Pyare Lal; Qurishi, Mushtaq A.; Koul, Surrinder; Saxena, Ajit Kumar

doi:10.1371/journal.pone.0108713

Cited by 29 publications

(25 citation statements)

References 27 publications

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“…This hypothesis was confirmed by the fact that when umbelliprenin was encapsulated in nanoliposomes its antiproliferative effect against 4T1 cells increased by five folds 50 . Also osthol (12) showed only a moderate cytotoxicity with an IC 50 of 98 lM but, as reported in previous works 54,55 , its cytotoxicity greatly depends on the cancer cell line.…”

Section: Cytotoxicity Of Compounds 5 9-12 and 15 Towards Cancer Cellssupporting

confidence: 72%

Coumarins fromMagydaris pastinaceaas inhibitors of the tumour-associated carbonic anhydrases IX and XII: isolation, biological studies and in silico evaluation

Fois

Distinto

Meleddu

et al. 2020

Journal of Enzyme Inhibition and Medicinal Chemistry

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In an in vitro screening for human carbonic anhydrase (hCA) inhibiting agents from higher plants, the petroleum ether and ethyl acetate extracts of Magydaris pastinacea seeds selectively inhibited hCA IX and hCA XII isoforms. The phytochemical investigation of the extracts led to the isolation of ten linear furocoumarins (1-10), four simple coumarins (12-15) and a new angular dihydrofurocoumarin (11). The structures of the isolated compounds were elucidated based on 1 D and 2 D NMR, MS, and ECD data analysis. All isolated compounds were inactive towards the ubiquitous cytosolic isoform hCA I and II (K i > 10,000 nM) while they were significantly active against the tumour-associated isoforms hCA IX and XII. Umbelliprenin was the most potent coumarin inhibiting hCA XII isoform with a K i of 5.7 nM. The cytotoxicity of the most interesting compounds on HeLa cancer cells was also investigated.

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Section: Cytotoxicity Of Compounds 5 9-12 and 15 Towards Cancer Cellssupporting

confidence: 72%

Coumarins fromMagydaris pastinaceaas inhibitors of the tumour-associated carbonic anhydrases IX and XII: isolation, biological studies and in silico evaluation

Fois

Distinto

Meleddu

et al. 2020

Journal of Enzyme Inhibition and Medicinal Chemistry

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“…Interestingly, the species are not evenly distributed. In fact, several families contain a strikingly large number of members compared with other plant families [50].…”

Section: Discussionmentioning

confidence: 99%

Anti-Prostate Cancer Activity of Plant-Derived Bioactive Compounds: a Review

Thomas-Charles

Fennell

2019

Curr Mol Bio Rep

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Purpose of Review Prostate cancer is one of the most common cancers in men and accounts for about 10% of all new cancer cases in the USA. Despite significant improvements in survival, it is estimated that deaths from prostate cancer in 2019 will exceed 30,000 individuals. Here, we review plant-derived bioactive compounds with the ability to modulate the growth of prostate cancer cells. These compounds represent potential therapeutic alternatives for the prevention and treatment of prostate cancer. Recent Findings Numerous plants produce phytochemicals that are important for their development and protection. Many of these compounds have inhibitory effects on the growth of cancer cells. Summary Cancers are a leading cause of death worldwide and treatments tend to be costly with many negative side effects. Identification of new potential chemo-therapeutic and chemo-protective compounds that have little or no negative effects on normal cells is therefore of great importance.

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“…These diterpene molecules are considered as the first representatives of this family to be described from the plant kingdom [25]. The current research programme was undertaken as part of our on-going research programme based on bioprospection of natural products [26][27][28][29][30][31][32]. Thorough review of literature revealed no reports of phytochemistry on S. sclarea of Kashmir origin.…”

Section: Advances In Biomedicine and Pharmacy (An International Journmentioning

confidence: 99%

Chemical constituents of Salvia sclarea from Kashmir (India).

Rahman¹

2017

Adv. Biomed. Pharma

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Salvia sclarea (Lamiaceae) commonly known as clarysage, is a medicinally important herb showing broad range of biological activities. This plant is mainly known because of its pleasantly smelling essential oils rich in linalool and linalyl acetate. In addition to linalool and linalyl acetate (major essential oil secondary metabolites), the peculiar aromatic note of the essential oil is because of the minor constituents including α-terpineol, geranyl acetate, (E)-caryophyllene, limonene, thymol, nerol, geranyl acetate etc. Phytochemical investigation of the aerial parts of this plant yielded nine compounds i.e. β-sitosterol, α-amyrin, ursolic acid, oleanolic acid, betulinic acid, sclareol, salvigenin, acacetin and norartocarpetin. The structures of these compounds have been established by spectroscopic methods (UV, IR, 1 H NMR, 13 C NMR and MS) in light of literature. Structure of ursolic acid has also been established by HMBC experiments. Ursolic acid, oleanolic acid, betulinic acid, salvigenin, acacetin and norartocarpetin are reported for the first time from this plant.

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Isolation, Cytotoxicity Evaluation and HPLC-Quantification of the Chemical Constituents from Prangos pabularia

Cited by 29 publications

References 27 publications

Coumarins fromMagydaris pastinaceaas inhibitors of the tumour-associated carbonic anhydrases IX and XII: isolation, biological studies and in silico evaluation

Coumarins fromMagydaris pastinaceaas inhibitors of the tumour-associated carbonic anhydrases IX and XII: isolation, biological studies and in silico evaluation

Anti-Prostate Cancer Activity of Plant-Derived Bioactive Compounds: a Review

Chemical constituents of Salvia sclarea from Kashmir (India).

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