Isolation of 24-epibrassinolide from leaves of Aegle marmelos and evaluation of its antigenotoxicity employing Allium cepa chromosomal aberration assay

Effects of brassinosteroids on barley root growth, antioxidant system and cell division

“…Recently, Howell et al (2007) observed great increase in the number of cells in prophase and telophase within 48 h of exposure to EBR. We also observed increase in the number of abnormal mitosis despite of recent reports on antigenotoxicity of BR (Sondhi et al 2008). There are reports on clastogenic effects of steroid hormones in human lymphocyte culture (Ahmad et al 2000).…”

“…(Symons et al 2008). Amelioration of both biotic and abiotic stresses and genotoxicity could also be possible exogenous BRs applications (Hayat et al 2007;Sondhi et al 2008;Shahbaz et al 2008). Brassinosteroids regulate the expression of numerous genes, affect the activity of complex metabolic pathways, and contribute to G. Kartal Á A. Temel Á E. Arican Á N. Gozukirmizi (&) Faculty of Science, Department of Molecular Biology and Genetics, Istanbul University, 34118 Vezneciler-Istanbul, Turkey e-mail: nermin@istanbul.edu.tr the regulation of cell division and differentiation.…”

“…Brassinosteroids and cell division interactions are other areas that need to be investigated in both tissue culture materials (Oh and Clouse 1998;Aydin et al 2006) and other conditions (Howell et al 2007). Recently it was shown that chromosomal aberrations induced by maleic hydrazide declined significantly by EBR treatment (Sondhi et al 2008).…”

Steroids: A Diverse Class of Secondary Metabolites

“…The BRs tend to counter biotic as well as abiotic stress in plants [79]. Application of BRs to cucumbers results in increased metabolism and removal of pesticides; this property of BRs could be beneficial for reducing the human ingestion of residual pesticides from non-organically grown vegetables [80]. The 24-epibranssinolide (EBL), a brassinolide isolated from Aegle marmelos Correa (Rutaceae), have been found to significantly reduce the maleic hydrazide (MH) induced genotoxicity in Allium cepa chromosomal abberation assay [81], and protect neuronal PC12 cells from 1-methyl-4-phenylpyridinium-(MPP + -) induced oxidative stress and apoptosis in dopaminergic neurons [82].…”

Salt Stress and Homobrassinosteroid Interactions during Germination in Barley Roots

“…'Bulbul 89') and chromosomal aberrations enhanced with increasing salt concentration. There are also different studies about BR effects on mitosis (Miyazawa et al, 2003;Aydin et al, 2006;Sondhi et al, 2008;Kartal et al, 2009).…”