Isolation of a 33-kDa protein antigen from delipidified Mycobacterium tuberculosis H 37 Rv

Deshpande, Rajashri G.; Khan, Mahfuz; Bhat, Deepashree A.; Navalkar, R. G.

doi:10.1007/s004300050025

Cited by 3 publications

(3 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nonsecreted or cytoplasmic proteins of mycobacteria have generally not been found to be major antigenic targets of T cell responses in M. tuberculosis-infected animals, although humoral responses have sometimes been found against such antigens (156)(157)(158). However, the fact that nonsecreted mycobacterial proteins do not strongly stimulate T cell responses during infection with live mycobacteria does not necessarily mean that these antigens cannot be the targets for protective T cell responses.…”

Section: Secreted Proteins As Immunological Decoysmentioning

confidence: 99%

Evasion of Innate and Adaptive Immunity byMycobacterium tuberculosis

Goldberg¹,

Saini²,

Porcelli

2014

Microbiol Spectr

View full text Add to dashboard Cite

Through thousands of years of reciprocal coevolution, Mycobacterium tuberculosis has become one of humanity's most successful pathogens, acquiring the ability to establish latent or progressive infection and persist even in the presence of a fully functioning immune system. The ability of M. tuberculosis to avoid immune-mediated clearance is likely to reflect a highly evolved and coordinated program of immune evasion strategies that interfere with both innate and adaptive immunity. These include the manipulation of their phagosomal environment within host macrophages, the selective avoidance or engagement of pattern recognition receptors, modulation of host cytokine production, and the manipulation of antigen presentation to prevent or alter the quality of T-cell responses. In this article we review an extensive array of published studies that have begun to unravel the sophisticated program of specific mechanisms that enable M. tuberculosis and other pathogenic mycobacteria to persist and replicate in the face of considerable immunological pressure from their hosts. Unraveling the mechanisms by which M. tuberculosis evades or modulates host immune function is likely to be of major importance for the development of more effective new vaccines and targeted immunotherapy against tuberculosis.

show abstract

Section: Secreted Proteins As Immunological Decoysmentioning

confidence: 99%

Evasion of Innate and Adaptive Immunity byMycobacterium tuberculosis

Goldberg¹,

Saini²,

Porcelli

2014

Microbiol Spectr

View full text Add to dashboard Cite

show abstract

“…This has been observed for antigens such as ESAT‐6 and Ag85B, which are secreted early after infection and tend to dominate as targets of the T‐cell responses in experimentally infected animals or humans with naturally acquired tuberculosis. On the other hand, T‐cell responses to cytosolic nonsecreted proteins have generally been found to be absent or weak in infected animals, although cellular and humoral responses have occasionally been reported to these (29–32). Recent experiments comparing M. tuberculosis strains that were engineered to either secrete or retain within the bacterial cell the antigen CFP‐10 confirmed that CD4 + and CD8 + T‐cell responses in vivo to this normally immunodominant antigen are dependent on its secretion (33).…”

Section: Antigenic Targets Of T‐cell Responses To M Tuberculosismentioning

confidence: 99%

“…Nonsecreted or cytoplasmic proteins of mycobacteria have generally not been found to be major antigenic targets of T‐cell responses in M. tuberculosis ‐infected animals, although humoral responses have sometimes been found against such antigens (29, 31, 32). However, the fact that nonsecreted mycobacterial proteins do not strongly stimulate T‐cell responses during infection with live mycobacteria does not necessarily mean that these antigens cannot be the targets for protective T‐cell responses.…”

Section: Strategies For Evasion or Subversion Of T‐cell Responses By mentioning

confidence: 99%

Evasion and subversion of antigen presentation by Mycobacterium tuberculosis

2009

View full text Add to dashboard Cite

Mycobacterium tuberculosis is one of the most successful of human pathogens and has acquired the ability to establish latent or progressive infection and persist even in the presence of a fully functioning immune system. The ability of M. tuberculosis to avoid immune-mediated clearance is likely to reflect a highly evolved and coordinated program of immune evasion strategies, including some that interfere with antigen presentation to prevent or alter the quality of T-cell responses. Here, we review an extensive array of published studies supporting the view that antigen presentation pathways are targeted at many points by pathogenic mycobacteria. These studies show the multiple potential mechanisms by which M. tuberculosis may actively inhibit, subvert or otherwise modulate antigen presentation by major histocompatibility complex class I, class II and CD1 molecules. Unraveling the mechanisms by which M. tuberculosis evades or modulates antigen presentation is of critical importance for the development of more effective new vaccines based on live attenuated mycobacterial strains.

show abstract