Isolation of a hexaprenylhydroquinone sulfate from the marine spongeDysidea sp. as an H, K-ATPase inhibitor

Abstract

A hexaprenylhydroquinone sulfate has been isolated as an H,K-ATPase inhibitor from a marine sponge Dysidea sp. It also inhibited phospholipase A2 as well as secretion of gastric acid in rats.

A New Hydroxylated Nonaprenylhydroquinone from the Mediterranean Marine Sponge Sarcotragus spinosulus

“…Biological studies conducted on several polyprenylhydroquinones showed them to have a moderate antibacterial [11,12], antiviral [13], anti-inflammatory [14,15], and phospholipase A2 activity [15]. These linear polyprenylhydroquinones could be further divided in two main groups with polyprenylhydroquinones sulfates [16–20] and hydroxylated polyprenylhydroquinones. To date only four hydroxylated polyprenylhydroquinones [5,6,20,21] have been isolated from Sarcotragus spinosulus (under the name Ircinia spinosula ).…”

Hexa-, hepta- and nonaprenylhydroquinones isolated from marine sponges Sarcotragus muscarum and Ircinia fasciculata inhibit NF-k B signalling in H4IIE cells

“…ircisulfamide) and glycosphingolipids (ircicerebroside) have been isolated from I. fasciculata . Fusetani and colleagues 5 isolated hexaprenylhydroquinone sulfate from a marine sponge Dysidea sp. and reported inhibitory activities on K‐ATPase and phospholipase A2.…”

Three New Heptaprenylhydroquinone Derivatives from the Sponge Ircinia fasciculata

“…Their structures have been established by spectral methods and chemical transformations.In the course of our search for bioactive metabolites from Indian marine invertebrates (1-3), we investigated the sponge Ircinia fasciculata Pallas (Spongillidae) collected on the coast of the Gulf of Mannar, India. In previous reports the genus Ircinia has been shown to produce fiiranosesterterpenes (4-6) and polyprenylated hydroquinones (7-8) [1][2][3][4].Recently, sulfated derivatives of polyprenylated hydroquinones [5, [7][8][9] and the chromenols 11-13 have been isolated from a Dysidea species (9) and Sarcotragus spinulosus (10). These sulfated metabolites have been shown to inhibit H+, K+ and Na+, K+-ATPase.…”