Isolation of a Mycoplasma Capable of Producing Polyarthritis in Mice

Okano, Hiroshi; Chosa, Hirofumi; Kusano, Nobuo

doi:10.3412/jsb.24.661

Cited by 1 publication

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In previous papers we dealt with experimental mycoplasmosis by Mycoplasma pulmonis (M. pulmonis) in dd strain mice (22,30,31). A high frequency of incidence of chronic polyarthritis and mycoplasma recovery from the affected joints has been reported by other investigators (2,8,14,15,26). Furthermore, perivascular mononuclear cell infiltrations were noticed in the lung, kidneys and liver in histopathological examinations.…”

supporting

confidence: 63%

“…In immunologically normal mice, such as nu/ + mice, strain dd mice (31), and those used by many investigators (2,8,14,15,26), mycoplasmal arthritis usually developed within one week after inoculation, and then the severity of arthritis decreased to a limited but definite degree ; this mild arthritis continued for almost their entire life span ; and extraarticular evidence of disease were rarely observed except for pneumonia. The clinical severity of arthritis was related to the quantity of organisms recovered from the arthritic joints (6,14).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Mycoplasma pulmonis Arthritis in Congenitally Athmic (Nude) Mice

Tanaka

1979

Microbiology and Immunology

View full text Add to dashboard Cite

Congenitally athymic BALB/cA nu/nu mice were employed to elucidate the role of the thymus in experimental Mycoplasma pulmonis strain m53 infection, and nu/+ mice were used for comparison. Chronic polyarthritis was frequently produced in both of nu/nu and nu/+ mice by intravenous injection of the organisms. Macroscopically, nu/nu mice developed severer arthritis and a much lower grade of resolution than nu/+ mice. Periarticular abscess, conjunctivitis, and emaciation were observed in some of the nu/nu mice, but not in the nu/+ mice. Mycoplasmas were isolated from joints and other tissues (including periarticular abscesses and eyelids) of infected nu/nu mice at higher frequencies as well as in greater quantities, and did not show any elimination trends for at least 20 weeks after inoculation. However, in nu/+ mice, mycoplasmas were almost exclusively located in joints, and distribution of organisms to the other organs disappeared soon after the infection. Increases in complement-fixing antibody titers were not related to the inhibition of mycoplasmal spread. Thymus-dependent functions that may in some way prevent growth and spread of mycoplasmas in mice are discussed.

show abstract

supporting

confidence: 63%