Isolation of a Novel Lichen Xanthone From the Genus Diploschistes s. lat

Abstract

1,8-Dihydroxy-3,6-dimethoxy-9H-xanthen-9-one ( 1 ) has been isolated from a lichen for the first time and its structure verified by unambiguous synthesis.

Abstracts of the 65th Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA)

“…The animal material of P. tuberculosa (4.0 kg) were extracted by ethanol and separated by consecutive column chromatography. As a result, three new pyrazines (1)(2)(3) and five known alkaloids (4)(5)(6)(7)(8) were isolated. The structures of all isolates were determined by analyzing their IR, Mass, NMR, and UV spectroscopic data.…”

“…All three, ATR and CATR and decoctions inhibited, in this in vitro system slightly the cell viability in a dose dependent manner, indicating a low cytotoxicity. As literature data reported of an obviously higher toxic effect of CATR in comparison to ATR [6] further comparative pharmacological analyses of both compounds are mandatory. Mo-Poster Session 1-PO-188 Development and validation of an HPLC-DAD method for iridoid glycoside screening in fresh plant parts from Plantago lanceolata L. Plantago lanceolata L. is a long-known medicinical plant, exhibiting multiple favorable properties like anti-bacterial and abbiritative effects.…”

“…Compounds 3-5 were identified as 11α-hydroxyscilliglaucoside (3), desacetylscillicyanosid (4), and hellebortin A (5), respectively, based on their physical and spectroscopic data. , Scheideler M 4,5,6 accounts for only 4% of all skin cancers but is responsible for ca. 79% of skin cancer deaths.…”

“…, cyclo(Ala-Ile) (6), hydroxytyrosol (7), N-acetyldopamine (8), N-acetyltyramine (9), and oleracein E (10) based on spectroscopic data analysis. All the isolates were evaluated for anti-platelet aggregation properties by monitoring clotting time.…”

“…In order to elucidate the structure of all isolated compounds, the full set of spectroscopic (1 & 2D NMR) (1), two procyanidin fractions, and the phenolic glucosides picein (6), triandrin (7), and salicortin (8). In an ATP assay, the MeOH extract reduced cell viability by approx.…”