Isolation of a type 3 vaccine-derived poliovirus (VDPV) from an Iranian child with X-linked agammaglobulinemia

Shahmahmoodi, Shohreh; Parvaneh, Nima; Burns, Cara C.; Asghar, Humayun; Mamishi, Setareh; Tabatabaie, Hamideh; Chen, Qi; Teimourian, Shahram; Gooya, Mohammad Mehdi; Esteghamati, A.; Mousavi, Taha; Yousefi, Maryam; Farrokhi, Kobra; Mashlool, Maryam; Kew, Olen M.; Nategh, R

doi:10.1016/j.virusres.2008.07.006

Cited by 40 publications

(27 citation statements)

References 31 publications

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“…1c). Nucleotide 472, which defines attenuation in the 59 NCR, had reverted back to wild-type in both PV3 recombinants, as is often seen in PV3 OPVderived strains (Rakoto-Andrianarivelo et al, 2008;Shahmahmoodi et al, 2008). However, the sites defining attenuation in VP3 (2034) and VP1 (2493) were unchanged, as also seen in other described PV3 OPVderived strains (Shahmahmoodi et al, 2008).…”

Section: Genetic Featuressupporting

confidence: 51%

“…Nucleotide 472, which defines attenuation in the 59 NCR, had reverted back to wild-type in both PV3 recombinants, as is often seen in PV3 OPVderived strains (Rakoto-Andrianarivelo et al, 2008;Shahmahmoodi et al, 2008). However, the sites defining attenuation in VP3 (2034) and VP1 (2493) were unchanged, as also seen in other described PV3 OPVderived strains (Shahmahmoodi et al, 2008). There were no changes in the antigenic sites or the CRE region of 557TAG 668GAA VP4 759AAG 759AAG 759AAG 820CAT 961GAA 865GAA VP2 1233TAC 1233TAC 1233TAC 1040TAA 100SAT 1117AAG 1371CAT 1120TAC 1222GAA 1258AAG 1463GAA 241EAK 1645CAT VP3 1990AG 415TAAD 1861TAC 1873AAG 2250GAA 2084AAG 448TAA 1991GAA 2409GAA 2409GAA 2410CAT 2150AAG 470IAV 2413TAC 2431AAG 2419TAA 559DAE VP1 2526AAG 2834TAC 2637CAT 632AAV 2909TAC 721IATd 2909TAC 721IATd 3367GAA 2790TAC 683MAT 2932TAC 3084TAA 3084TAA 3084TAA 3330TAA 3378GAA 2A 3455AAT 903QAL 3460AAG 3364TAC 3658AAG 3409TAA 3682CAT 3511AAT 923KAN 3552CAT 937AAV 2B 4029CAT 3945AAG 4071GAA 2C 4308CAA 4129GAA 1395DAN 4188GAA 4473GAA § 4473GAA § 4473GAA § 4925GAA 4299TAC 4779AAG 4779AAG 44...…”

Section: Genetic Featuresmentioning

confidence: 83%

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Comparison of poliovirus recombinants: accumulation of point mutations provides further advantages

Savolainen-Kopra

Самойлович

Kahelin

et al. 2009

Journal of General Virology

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The roles of recombination and accumulation of point mutations in the origin of new poliovirus (PV) characteristics have been hypothesized, but it is not known which are essential to evolution. We studied phenotypic differences between recombinant PV strains isolated from successive stool specimens of an oral PV vaccine recipient. The studied strains included three PV2/PV1 recombinants with increasing numbers of mutations in the VP1 gene, two of the three with an amino acid change IAT in the DE-loop of VP1, their putative PV1 parent and strains Sabin 1 and 2. Growth of these viruses was examined in three cell lines: colorectal adenocarcinoma, neuroblastoma and HeLa. The main observation was a higher growth rate between 4 and 6 h post-infection of the two recombinants with the IAT substitution. All recombinants grew at a higher rate than parental strains in the exponential phase of the replication cycle. In a temperature sensitivity test, the IATsubstituted recombinants replicated equally well at an elevated temperature. Complete genome sequencing of the three recombinants revealed 12 (3), 19 (3) and 27 (3) nucleotide (amino acid) differences from Sabin. Mutations were located in regions defining attenuation, temperature sensitivity, antigenicity and the cis-acting replicating element. The recombination site was in the 59 end of 3D. In a competition assay, the most mutated recombinant beat parental Sabin in all three cell lines, strongly suggesting that this virus has an advantage. Two independent intertypic recombinants, PV3/PV1 and PV3/PV2, also showed similar growth advantages, but they also contained several point mutations. Thus, our data defend the hypothesis that accumulation of certain advantageous mutations plays a key role in gaining increased fitness.

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Section: Genetic Featuressupporting

confidence: 51%

Section: Genetic Featuresmentioning

confidence: 83%

Comparison of poliovirus recombinants: accumulation of point mutations provides further advantages

Savolainen-Kopra

Самойлович

Kahelin

et al. 2009

Journal of General Virology

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“…In the present study, most of our patients with humoral or combined immunodeficiencies were receiving substitutive immunoglobulin therapy at sampling time. Based on data in the literature, the possible role of this treatment in facilitating the clearance of poliovirus infection remains unclear because some prolonged poliovirus infections may have responded to treatment (7,26) while others have not (5,18,20) or have resolved spontaneously (15). Most of the poliovirus excreters detected in this series (5 out of 6) had a limited period of excretion, while most of those excreting a nonpolio enterovirus (4 out of 6) had prolonged excretion despite the fact that they were receiving substitutive immunoglobulin therapy.…”

Section: Discussionmentioning

confidence: 99%

High Susceptibility for Enterovirus Infection and Virus Excretion Features in Tunisian Patients with Primary Immunodeficiencies

Driss

Ben‐Mustapha

Mellouli

et al. 2012

Clin. Vaccine Immunol.

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To estimate the susceptibility to enterovirus infection and the frequency of long-term poliovirus excreters in Tunisian patients with primary immunodeficiencies (PIDs), enteroviruses were assessed in stool specimens of 82 patients with humoral, combined, and other PIDs. Isolated viruses were typed and intratyped by standard molecular techniques, and the whole VP1 region of poliovirus isolates was sequenced. Polioviruses were detected in 6 patients; all isolates were vaccine related. Five patients rapidly stopped excretion; one excreted a poliovirus type 1 isolate for several months, and the isolate accumulated up to 14 mutations in the VP1 region. Nonpolio enteroviruses were identified in 6 patients; 4 of them kept excreting the same strain for more than 6 months. The rate of enterovirus infection was 13.4% of the PID patients and 20.7% of those with an IgG defect; it greatly exceeded the rates generally found in Tunisian supposed-immunocompetent individuals (4.1% during the study period; P ‫؍‬ 0.001 and P < 0.0001, respectively). Interestingly, patients with combined immunodeficiencies were at a higher risk for enterovirus infection than those with an exclusively B cell defect. A major histocompatibility complex (MHC) class II antigen expression defect was found in 54% of enterovirus-positive patients and in the unique long-term poliovirus excreter. The study results also suggest that substitutive immunoglobulin therapy may help clearance of a poliovirus infection and that most PID patients have the ability to stop poliovirus excretion within a limited period. However, the high susceptibility of these patients to enterovirus infection reinforces the need for enhanced surveillance of these patients until the use of oral poliovirus vaccine (OPV) is stopped.

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“…The mosaic structures of the noncapsid region may change over the 4-to 8-week period of excretion with further genetic exchanges among the OPV strains (27) but subsequently stabilize, and intertypic recombination sites remain conserved in highly divergent VDPV recombinants (3,18,24). P1/capsid region sequences of the Estonian VDPVs clustered by serotype on maximum likelihood trees, consistent with a pattern of little or no intertypic P1/capsid region recombination (Fig.…”

mentioning

confidence: 80%

“…Most cVDPVs are vaccine/nonvaccine recombinants with limited substitution in the neutralizing antigenic (NAg) sites (8,12,21). In contrast, most iVDPV isolates have nonrecombinant or vaccine/ vaccine recombinant genomes, multiple substitutions in the NAg sites (8,13,14,16), and numerous mixed-base positions (reflecting divergence into separate lineages during prolonged infections) (13,14,(22)(23)(24).…”

mentioning

confidence: 99%

Highly Divergent Type 2 and 3 Vaccine-Derived Polioviruses Isolated from Sewage in Tallinn, Estonia

Al-Hello

Jorba

Blomqvist

et al. 2013

J Virol

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Isolation of a type 3 vaccine-derived poliovirus (VDPV) from an Iranian child with X-linked agammaglobulinemia

Cited by 40 publications

References 31 publications

Comparison of poliovirus recombinants: accumulation of point mutations provides further advantages

Comparison of poliovirus recombinants: accumulation of point mutations provides further advantages

High Susceptibility for Enterovirus Infection and Virus Excretion Features in Tunisian Patients with Primary Immunodeficiencies

Highly Divergent Type 2 and 3 Vaccine-Derived Polioviruses Isolated from Sewage in Tallinn, Estonia

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