Isolation of alkaloids compound of ethanol extract of mangrove perepat (S. alba) root and its antibacterial activity

Abstract

Background: Exploration of the chemical contents and bioactivities of mangrove plants is important to discover new therapeutic agents for society and to develop its medicinal values. Objective: This study aims to isolate alkaloid compounds from the ethanol extract of Sonneratia alba root which is likely to have an antibacterial activity. Methods: Isolation was carried out using fractionation and chromatography, while antibacterial activity test was performed using the disc diffusion methods. Results: Our phytochemical screening shows that the ethanol extract has a high concentration of alkaloid compounds. The alkaloid which contain in isolate (F4) is further confirmed through UV-Vis Spectra and FT-IR spectra. The ethanol extract exhibits the antibacterial activity against S. aureus and E. coli with the inhibition zone of 1.5 mm and 2.5 mm, respectively. Conclusion: Alkaloid compound has been isolated from Sonneratia alba and has potential as antibacterial agent. Keywords: mangrove perepat (Sonneratia alba), alkaloid, antibacterial agent

Study on the Utilization of Mangrove Forest Plants

“…The perepat plant (Sonneratia alba), commonly found in mangrove forests, possesses antimicrobial properties and contains various enzymes that play a crucial role in the mangrove ecosystem and have the potential for applications in various industries. The antimicrobial properties of this plant are related to the production of compounds such as tannins and flavonoids, which are effective in inhibiting the growth of pathogenic microorganisms in the mangrove environment, thus contributing to maintaining ecosystem balance (Latief et al, 2019;Mairing & Ariantari, 2022;Latief, et al, 2021). Additionally, perepat also contains enzymes like peroxidase and cellulase, which play a role in the detoxification of toxic compounds and the breakdown of complex organic matter, such as cellulose.…”