Isolation of an Immunosuppressive Fraction from Uremic Ultrafiltrates

Navarro, Jean-Marc; Grossetête, M. C.; Touraine, Jean Louis; Traeger, J

doi:10.1007/978-1-4684-5445-1_26

Cited by 1 publication

(1 citation statement)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Various T lymphocyte functions, such as PHA and Con-A-induced blast transformation, mixed lymphocyte reaction (MLR) and autologous MLR (aMLR), were found to be impaired in chronic renal failure [26,27]. A number of factors in uremic serum were shown to produce inhibition of lympho cyte activation [28]. Others found increased suppres sor cell activity in lymphocytes from uremic patients [15,29,30].…”

Section: Discussionmentioning

confidence: 99%

1,25-Dihydroxyvitamin D-Induced Suppressor Cells in Uremic versus Normal Lymphocytes

Modai

Weissgarten²,

Stelian³

et al. 1988

Int Arch Allergy Immunol

View full text Add to dashboard Cite

1,25-Dihydroxyvitamin D₃ (DHD) has been shown to suppress mitogen-induced blast transformation. This inhibition is abolished by prior elimination of adherent cells. Chronic renal failure is an immunodeficiency state on the one hand and is associated with abnormalities in vitamin D metabolism on the other. The effect of DHD on the induction of suppressor cells in uremic vs. normal peripheral blood mononuclear cells was investigated. Study groups included 16 chronically uremic patients and 16 age- and sex-matched controls. DHD induced suppressor cell activity in normal lymphocytes. However, no suppressor cell activity was observed in lymphocytes from the uremic patients preincubated with DHD. The origin of the responder cells (normal or uremic) did not affect the outcome. The results would suggest that monocyte-adherent suppressor cells from uremic subjects are either incapable of binding DHD or fail to mount a normal post-receptor intracellular chain of events culminating in suppressor activity.

show abstract