1973
DOI: 10.1128/jvi.11.6.978-985.1973
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Isolation of an RD-114-Like Oncornavirus from a Cat Cell Line

Abstract: A clone of cells derived from a continuous line of cat cells (CCC) spontaneously produced an RNA C-type virus (CCC virus) which did not have the groupspecific antigen of the standard strains of feline leukemia viruses but did have that of the RD-114 virus. Single-hit infection of a virus yielding CCC cell with only the feline leukemia virus pseudotype of murine sarcoma virus [MSV(FeLV) ] resulted in the release of a pseudotype of MSV coated with the CCC virus envelope. Host range, transmission of virus, helper… Show more

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Cited by 139 publications
(53 citation statements)
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“…Domestic cats are generally assumed to harbour the infectious endogenous retrovirus RD114 in their genome [1,2]. It is known that the Crandell-Rees feline kidney cell line is contaminated with an RD114-like virus [3].…”
Section: Introductionmentioning
confidence: 99%
“…Domestic cats are generally assumed to harbour the infectious endogenous retrovirus RD114 in their genome [1,2]. It is known that the Crandell-Rees feline kidney cell line is contaminated with an RD114-like virus [3].…”
Section: Introductionmentioning
confidence: 99%
“…The risks posed by a low-level exposure to RD-114 for pets are likely extremely small. ERVs are in general nonpathogenic for their host species, and RD-114 replication has been found to be restricted in some cat cell lines (4,5,12). However, cat cell lines fully susceptible to RD-114 replication have also been described (7).…”
mentioning
confidence: 99%
“…All domestic cats have an infectious ERV, termed RD-114 virus [4,12,32]. RD-114 viral genomes have not been detected in large felids, such as lions and pumas [4].…”
Section: Feline Ervsmentioning
confidence: 99%