Isolation of antioxidant phenolics from Schinopsis brasiliensis based on a preliminary LC-MS profiling

Santos, Clisiane Carla de Souza; Masullo, Milena; Cerulli, Antonietta; Mari, Angela; Estevam, Charles dos Santos; Pìzza, Cosimo; Piacente, Sonia

doi:10.1016/j.phytochem.2017.04.008

Cited by 30 publications

(15 citation statements)

References 25 publications

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“…In addition, four galloyl derivatives were also detected at different retention times depending on their apolar substituents as methoxy groups: dimethoxy-hydroxyphenyl- O -galloyl glucopyranoside, hydroxyl-methoxyphenyl- O -galloyl glucopyranoside, galloyl-glucosyl dihydroxymethoxyacetophenone, and trihydroxystilbene glucosyl- O -gallate at m / z 483, 453, 495, and 541, respectively (peaks 28, 32, 39, and 56). Among them, peaks 28 and 32 have previously been mentioned in the literature for other barks [23,24,25], but this is the first time that they were detected in S. birrea .…”

Section: Resultsmentioning

confidence: 87%

Enhancing the Yield of Bioactive Compounds from Sclerocarya birrea Bark by Green Extraction Approaches

et al. 2019

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Sclerocarya birrea is a tree indigenous to Southern Africa with significant importance in rural livelihoods for food, medicine, and carving. The bark, which contains 10–20% tannin, provides several pharmacological benefits as an antidiabetic, anti-inflammatory, antimicrobial, anti-atherogenic, and antioxidant medication, among others. This study compared different extraction techniques used to recover bioactive compounds from marula bark. For this purpose, solid–liquid extraction, supercritical fluid extraction (SFE), and pressurized liquid extraction (PLE) were performed under selected conditions, using only “food-grade” solvents. The potential use of the proposed extraction methodologies was evaluated in term of yield, and the individual phenolic composition determined by HPLC–ESI–TOF–MS. PLE provided a high extraction yield in all experimental conditions. With regard to bioactive compounds composition, a total of 71 compounds, a significant percentage of which in a galloyl form, were distributed in five major categories. The largest number of compounds, mostly flavonoid aglycones, were extracted by PLE, generally when the extraction was developed at low temperatures. SFE did prove effective as a way of extracting antidiabetic proanthocyanidins. Advanced extraction techniques represent a powerful tool to obtain bioactive compounds from S. birrea bark, which can be used as supplements or food ingredients, promoting the valorization of this crop.

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Section: Resultsmentioning

confidence: 87%

Enhancing the Yield of Bioactive Compounds from Sclerocarya birrea Bark by Green Extraction Approaches

et al. 2019

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“…The butanolic and chloroformic fractions of Santolina chamaecyparissus L. were analyzed for their total phenolic content according to the Folin-Ciocalteu (FC) colorimetric method [19] determined according to the procedure previously reported. Butanolic and chloroformic fractions were dissolved in methanol to obtain a concentration of 0.5 mg/mL.…”

Section: Determination Of Total Phenolic Content (Folin−ciocalteu Metmentioning

confidence: 99%

Chemical Constituents of the Aerial Parts of Santolina chamaecyparissus and Evaluation of Their Antioxidant Activity

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Masullo

Cerulli

et al. 2017

Natural Product Communications

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Santolina chamaecyparissus is an aromatic evergreen herb growing in North Africa and near the Mediterranean coasts of Southern Europe. Literature data focused mainly on the investigation of the essential oil content of the aerial parts of S. chamaecyparissus, but few is known on the chemical composition of its polar extract. Total phenolic content was determined by the Folin-Ciocalteau method and the antioxidant activity of the n-butanol and chloroform fractions of S. chamaecyparissus was tested by Trolox equivalent antioxidant capacity (TEAC) and diphenyl-2-picrylhydrazyl radical (DPPH•) assays. Difference of the phenolic content and of the antioxidant activity between the two extracts prompted us to investigate their chemical composition. Five compounds, eupatilin (1), circimaritin (2), 4'-hydroxy-5,6,7-trimethoxyflavone (3), 1,3-propanediol,2-amino 1-(4-hydroxy-3-methoxyphenyl) (4) and luteolin (5) have been isolated from the chloroform extract, while the investigation of butanolic extract led to the isolation of seven compounds, prunasin (6), luteolin 7-O-β-D-glucopyranoside (7), syringoside (8), junipeionoloside (9), citroside A (10), lonicerin (11) and apigenin 7-O-β-D-neohesperidoside (12). Their structures were elucidated by extensive spectroscopic methods including 1D-(1 H, 13 C and TOCSY) and 2D-NMR (DQF-COSY, HSQC, HMBC) experiments as well as ESIMS analysis.

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“…In this context, the Schinopsis brasiliensis Engl., is used in folk medicine to combat various diseases, including toothache, diarrhea, flu, and inflammations (Agra et al 2006, Albuquerque 2006, Albuquerque et al 2007, 2012. The bark of S. brasiliensis presents polyphenols, flavonoids, tannins, and saponins (Chaves et al 2015, Fernandes et al 2015) and a lot of compounds with biological activities have been isolated (Cardoso et al 2005, 2015, Santos et al 2017. In this way, Santos et al (2014) detected flavonoids and tannins in the hydroalcoholic extract of the bark of S. brasiliensis, along with the absence of toxicity.…”

Section: Introductionmentioning

confidence: 99%

Schinopsis brasiliensis Engl. to combat the biofilm-dependents diseases in vitro

Sette‐de‐Souza

Santana

Sousa

et al. 2020

An. Acad. Bras. Ciênc.

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Dental caries and periodontal disease are the most prevalent of the biofilmdependent diseases. With numerous side effects on the use of chlorhexidine, the search for new safe therapeutic alternatives for microorganisms involved with these diseases increases every day. This study aimed to evaluate the antimicrobial activity and cytotoxicity of extracts made from the bark of Schinopsis brasiliensis Engl. against five oral microorganisms and analyze their phytochemical and thermal degradation profile. The liquid-liquid partition was performed with hexane, chloroform and ethyl acetate. The identification and quantification of the chemical marker was done. Antimicrobial activity was evaluated based on the minimum inhibitory concentration. The cytotoxicity was analyzed based on the hemolysing potential of the samples. The thermal degradation profile was performed by two different methods. Gallic acid was identified as the main compound of the samples and showed the highest amount in the chloroform fraction. All samples were able to inhibit the growth of the microorganisms tested and showed no cytotoxicity. The ethanol extract absorbs less heat than the fractions. All samples exhibited exothermic peak consistent with degradation of gallic acid. Based on the results, the samples used are potential candidates for use in dental formulations for biofilm control.

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Isolation of antioxidant phenolics from Schinopsis brasiliensis based on a preliminary LC-MS profiling

Cited by 30 publications

References 25 publications

Enhancing the Yield of Bioactive Compounds from Sclerocarya birrea Bark by Green Extraction Approaches

Enhancing the Yield of Bioactive Compounds from Sclerocarya birrea Bark by Green Extraction Approaches

Chemical Constituents of the Aerial Parts of Santolina chamaecyparissus and Evaluation of Their Antioxidant Activity

Schinopsis brasiliensis Engl. to combat the biofilm-dependents diseases in vitro

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