Isolation of Conduritol A from<i>Gymnema sylvestre</i>and Its Effects against Intestinal Glucose Absorption in Rats

Miyatake, Kazutaka; Takenaka, Shigeo; Fujimoto, Tadashi; Kensho, Goro; Upadhaya, Shanti Priya; Kirihata, Mitsunori; Ichimoto, Itsuo; Nakano, Yoshihisa

doi:10.1271/bbb.57.2184

Cited by 9 publications

(2 citation statements)

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“…Pharmacological studies showed that G. sylvestre has hypoglycemic [4,5], anti-caries [6,7] and weight reducing [8,9,10] effects. Triterpenoids [11,12,13,14,15,16,17,18], cyclitols [19], flavonoids [20], peptides [21], pectin [22] and alkaloids [23,24] have been isolated from this plant. Some triterpene saponins from G. sylvestre were found to be able to attenuate hyperglycemia induced by pituitary growth hormone or adrenocorticotropic hormone [25,26] and to inhibit intestinal glucose absorption in diabetic rats [27,28,29,30].…”

Section: Introductionmentioning

confidence: 99%

New Pregnane Glycosides from Gymnema sylvestre

Yang

Zhang

et al. 2015

Molecules

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Abstract:Four new pregnane glycosides 1-4 were isolated from the ethanol extract of the stem of Gymnema sylvestre and named gymsylvestrosides A-D. Hydrolysis of compound 1 under the catalysis of Aspergilus niger β-glucosidase afforded compound 5 (gymsylvestroside E). Their structures were determined by spectroscopic methods such as HRESIMS, 1D and 2D NMR, as well as HMQC-TOCSY experiment. Compounds 1-4 were screened for Saccharomyces cerevisiae α-glucosidase inhibitory activity.

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Section: Introductionmentioning

confidence: 99%

New Pregnane Glycosides from Gymnema sylvestre

Yang

Zhang

et al. 2015

Molecules

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“…There are reports that G. sylvestre leaf extracts reduce hyperglycaemia in diabetic rabbits (Shanmugasundaram et al 1983), rats (Srivastava et al 1985) and humans (Khare et al 1983, Baskaran et al 1990, and these glucose-decreasing effects may be mediated by increases in insulin secretion (Shanmugasundaram & Panneerselvam 1981). There has been little systematic characterisation of the identities of the insulinotropic agents within the leaf extracts, but aqueous ethanolic extractions of the leaves provide two potentially active fractions, one containing conduritol A, an acid-soluble polyol-polyhydroxy cyclic compound (Miyatake et al 1993), and the other containing a mixture of acidinsoluble triterpenoid saponins (gymnemic acids), designated GS3 and GS4 ).…”

Section: Introductionmentioning

confidence: 99%

Gymnema sylvestre stimulates insulin release in vitro by increased membrane permeability

Persaud

Al-Majed²,

Raman³

et al. 1999

Journal of Endocrinology

166

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To determine whether extracts of Gymnema sylvestre may have therapeutic potential for the treatment of noninsulin-dependent diabetes mellitus (NIDDM), we examined the effects of an alcoholic extract of G. sylvestre (GS4) on insulin secretion from rat islets of Langerhans and several pancreatic -cell lines. GS4 stimulated insulin release from HIT-T15, MIN6 and RINm5F -cells and from islets in the absence of any other stimulus, and GS4-stimulated insulin secretion was inhibited in the presence of 1 mM EGTA. Blockade of voltage-operated Ca 2+ channels with 10 µM isradipine did not significantly affect GS4-induced secretion, and insulin release in response to GS4 was independent of incubation temperature. Examination of islet and -cell integrity after exposure to GS4, by trypan blue exclusion, indicated that concentrations of GS4 that stimulated insulin secretion also caused increased uptake of dye. Two gymnemic acidenriched fractions of GS4, obtained by size exclusion and silica gel chromatography, also caused increases in insulin secretion concomitant with increased trypan blue uptake. These results confirm the stimulatory effects of G. sylvestre on insulin release, but indicate that GS4 acts by increasing cell permeability, rather than by stimulating exocytosis by regulated pathways. Thus the suitability of GS4 as a potential novel treatment for NIDDM can not be assessed by direct measurements of -cell function in vitro.

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2022

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Isolation of Conduritol A fromGymnema sylvestreand Its Effects against Intestinal Glucose Absorption in Rats

Cited by 9 publications

References 1 publication

New Pregnane Glycosides from Gymnema sylvestre

New Pregnane Glycosides from Gymnema sylvestre

Gymnema sylvestre stimulates insulin release in vitro by increased membrane permeability

Vegetal Taste Modifiers

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