Isolation of cytotoxic triterpenes from the mangrove plant, &lt;i&gt;Scyphiphora hydrophyllacea&lt;/i&gt; C.F.Gaertn (Rubiaceae)

Samarakoon, Sameera Ranganath; Ediriweera, Meran Keshawa; Wijayabandara, Lakshan; Fernando, Narmada; Tharmarajah, Luxmiga; Tennekoon, Kamani Hemamala; Piyathilaka, Poorna; Adhikari, Achyut

doi:10.4314/tjpr.v17i3.13

Cited by 11 publications

(6 citation statements)

References 19 publications

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“…The analysis of the correlation signals in the 1 H-1 H COSY NMR spectrum of 1 (shown in Figure S7) provided further support for its elucidated structure. The NMR data of 1 (Table 1) were in agreement with the published values [19]. It is worth mentioning here that compound 1 is known to have anti-inflammatory, antihyperlipidemic, and hepatoprotective in vivo effects.…”

Section: Oleanolic Acid (1)supporting

confidence: 87%

New Constituents from the Leaves of Date Palm (Phoenix dactylifera L.) of Saudi Origin

et al. 2021

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The phytochemical analysis of the butanolic extract from the leaves of date palm of Saudi origin resulted in the isolation of three major constituents, oleanolic acid (1), vanillyl alcohol (2), and β-sitosterol-3-O-β-d-glucoside (3), which had not been isolated from this plant or previously reported. Together, compounds 1 and 2 account for 1.0% of the butanol extract, which represents 0.4% of the mass of the dried leaves. The isolation of other known compounds for this plant such as fatty acids, lutein, and sucrose was also achieved in this study. The characterization and identification of the isolated compounds were conducted on the basis of Fourier-transform infrared spectroscopy (FTIR), 1H and 13C nuclear magnetic resonance (NMR), liquid chromatography–mass spectrometry (LC–MS), and gas chromatography–mass spectrometry (GC–MS) analyses. The findings of the current study will definitely increase the knowledge about the contribution of the constituents of this plant to its well-known nutrition, corrosion inhibition, and antimicrobial properties.

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Section: Oleanolic Acid (1)supporting

confidence: 87%

New Constituents from the Leaves of Date Palm (Phoenix dactylifera L.) of Saudi Origin

et al. 2021

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“…Hexane and chloroform extracts of the leaves of Scyphiphora hydrophylacea yielded compound, namely, oleanolic acid 22 . Oleanolic acid has been isolated for the first time in Sri Lanka and demonstrated in vitro cytotoxic effects in estrogen receptor-positive (MCF-7) and nonsmall lung cancer (NCI-H-292) cells [72]. Triterpenoid has been reported to show anti-inflammatory, antitumor, hepatoprotective, antidiabetic, and antibacterial properties [72–74].…”

Section: Methodsmentioning

confidence: 99%

A Review on Antidiabetic Properties of Indian Mangrove Plants with Reference to Island Ecosystem

Sachithanandam

Lalitha

Parthiban

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Mangrove ecosystem has many potential species that are traditionally used by the coastal communities for their traditional cure for health ailments as evidenced by their extensive uses to treat hepatic disorders, diabetes, gastrointestinal disorders, anti-inflammation, anticancer, and skin diseases, etc. In recent times, the diabetes mellitus (DM), a serious physiological disorder all over the world, occur due to the relative or complete deficiency of insulin in the body, characterized by an abnormally high blood glucose level. India has a rich traditional knowledge on plant-based drug formulations that are protective and curative for many health ailments. In this context, we aimed to compile the works done on the antidiabetic activities of mangrove species from Indian coastal regions especially on Andaman and Nicobar Islands as well as some recent works reported from other countries. A total of 126 published articles and 31 mangrove species related pieces of information were gathered with reference to antidiabetic properties of mangroves. This review summarizes the chemical structures, molecular formula, molecular weight, and their biological activities with an aspiration that it might be helpful for the future bioprospecting industries who are interested in develop the natural drugs for DM.

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“…The active hexane and chloroform extracts, respectively, of the mangrove plant ( Scyphiphora hydrophyllace a C.F. Gaertn) were used as source of isolated compounds—ursolic, oleanolic, and eichlerianic acid—which were subsequently tested as cytotoxic agents against the ER positive (MCF-7) breast cancer cells; all three compounds showed significant growth inhibition effects accompanied by cell morphological changes ( 144 ). Ursolic acid isolated from the ethyl acetate fraction of Betula utilis D.Don methanolic extract was found to be highly effective as cytotoxic agent on MCF-7 breast cancer cells while non-tumorigenic breast epithelial MCF-10A cells remained unaffected, thus emphasizing a selective anticancer activity; an apoptotic effect was identified and attributed to the up-regulation of DR4, DR5 and PARP cleavage ( 145 ).…”

Section: Triterpenes As Therapeutic Agents In Sex Hormone-dependent Cmentioning

confidence: 99%

Natural Compounds in Sex Hormone-Dependent Cancers: The Role of Triterpenes as Therapeutic Agents

et al. 2021

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Sex hormone-dependent cancers currently contribute to the high number of cancer-related deaths worldwide. The study and elucidation of the molecular mechanisms underlying the progression of these tumors was a double-edged sword, leading to the expansion and development of new treatment options, with the cost of triggering more aggressive, therapy resistant relapses. The interaction of androgen, estrogen and progesterone hormones with specific receptors (AR, ER, PR) has emerged as a key player in the development and progression of breast, ovarian, prostate and endometrium cancers. Sex hormone-dependent cancers share a common and rather unique carcinogenesis mechanism involving the active role of endogenous and exogenous sex hormones to maintain high mitotic rates and increased cell proliferation thus increasing the probability of aberrant gene occurrence and accumulation highly correlated with abnormal cell division and the occurrence of malignant phenotypes. Cancer related hormone therapy has evolved, currently being associated with the blockade of other signaling pathways often associated with carcinogenesis and tumor progression in cancers, with promising results. However, despite the established developments, there are still several shortcomings to be addressed. Triterpenes are natural occurring secondary metabolites biosynthesized by various pathways starting from squalene cyclization. Due to their versatile therapeutic potential, including the extensively researched antiproliferative effect, these compounds are most definitely a cornerstone in the research and development of new natural/semisynthetic anticancer therapies. The present work thoroughly describes the ongoing research related to the antitumor activity of triterpenes in sex hormone-dependent cancers. Also, the current review highlights both the biological activity of various triterpenoid compounds and their featured mechanisms of action correlated with important chemical structural features.

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Isolation of cytotoxic triterpenes from the mangrove plant, <i>Scyphiphora hydrophyllacea</i> C.F.Gaertn (Rubiaceae)

Cited by 11 publications

References 19 publications

New Constituents from the Leaves of Date Palm (Phoenix dactylifera L.) of Saudi Origin

New Constituents from the Leaves of Date Palm (Phoenix dactylifera L.) of Saudi Origin

A Review on Antidiabetic Properties of Indian Mangrove Plants with Reference to Island Ecosystem

Natural Compounds in Sex Hormone-Dependent Cancers: The Role of Triterpenes as Therapeutic Agents

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