Isolation of Eikenella corrodens from human infections: Report of six cases

Maia, Anderson Luiz Pinheiro; Goldstein, F. W.; Acar, J. F.; Roland, F

doi:10.1016/s0163-4453(80)92792-9

Cited by 11 publications

(3 citation statements)

References 11 publications

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“…E. corrodens, a microaerophilic gram-negative bacillus, is part of the flora of the mouth, upper respiratory tract, and female genital tract (30). E. corrodens has been cultured from brain abscesses, subdural empyemas, meningitis, sinus infections, and osteomyelitis (5,7,21,37).…”

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confidence: 99%

A longitudinal microbiological investigation of Actinobacillus actinomycetemcomitans and Eikenella corrodens in juvenile periodontitis

Mandell¹

1984

Infect Immun

130

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Longitudinal clinical and microbiological monitoring of subjects with localized juvenile periodontitis indicated that Actinobacillus actinomycetemcomitans and Eikenella corrodens were significantly associated (P < 0.05) with active tissue destruction.Localized juvenile periodontitis (LJP) is a distinct clinical form of periodontal disease. In its classic form, it is a disease of adolescents in which individuals between 12 and 20 years of age demonstrate a rapid loss of supporting alveolar bone around the first permanent molars and incisors (1,8). The classic condition exhibits apparent minimal clinical inflammation, bacterial plaque, calculus, or pain. It is a particularly intriguing condition in that a hereditary component has been hypothesized (4,38). In a study of LJP patients, Newman et al. (35) described two numerically dominant groups of microorganisms, groups III and IV, which were later shown to include strains of Actinobacillus actinomycetemcomitans (46).A cross-sectional study of 42 patients by Slots et al. (39) revealed a carrier rate of A. actinomycetemcomitans in 20% of normal juveniles, 36% of normal adults, and 50 and 90% of adult periodontitis and LJP patients, respectively. Zambon et al. (53) examined 403 patients for the incidence of A. actinomycetemcomitans and found 95% of juvenile periodontitis patients harbored the organism, whereas only 15% of his other population groups did. In a recent study, Mandell and Socransky (31) examined the subgingival flora of deep pockets displaying radiographic bone loss. They found a significant association between A. actinomycetemcomitans and LJP but not with gingivitis or adult periodontitis.The purpose of this investigation was to longitudinally follow sites in an LJP population and their siblings. Utilizing the running median technique (11), periodontal pockets undergoing active destruction would be identified and cultured for a group of organisms, including Bacteroides intermedius, Actinomyces spp., Fusobacterium nucleatum, Capnocytophaga spp., Streptococcus spp., A. actinomycetemcomitans, and Eikenella corrodens. These groups were sought because prior reports (34,40,42) related each of these organisms with health or disease.Eight patients aged 10 to 18 years were selected for study. Longitudinal attachment measurements were performed (11) on days 1, 7, 30, and 37 after entry into the study by the patients. Active disease was defined as a loss of connective tissue attachment of .2 mm. A total of 168 sites per patient (6 sites per tooth) were followed, so that over 1,200 total sites were studied. Of these sites or pockets, eight displayed active disease. An additional 16 sites were selected as controls. Pocket depths averaged 8.4 mm (range 5 to 10 mm) in the diseased sites versus 4.8 mm (range 3 to 7 mm) in the 778 control sites. The sampled sites were either molars or incisors, because these areas are most frequently affected in LJP (20). Subgingival plaque samples were taken from the base of the periodontal pockets with a sterile Morse (00) scaler inser...

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confidence: 99%

A longitudinal microbiological investigation of Actinobacillus actinomycetemcomitans and Eikenella corrodens in juvenile periodontitis

Mandell¹

1984

Infect Immun

130

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“…3) Although, E. corrodens is notoriously difficult to culture meaning the true number of positive wound cultures may have been underestimated thus skewing results. 18) This finding might be different in the future if detection of E. corrodens were routinely performed through polymerase chain reaction technology.…”

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Predicting Amputation and Multiple Debridements in Tooth Knuckle Injuries

Smith

Conyard

Loveridge

et al. 2019

J Hand Surg Asian-Pac Vol

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Background: Tooth knuckle injuries can be expensive to treat and may necessitate amputation in some cases. Several limitations exist in the literature regarding our knowledge around the factors predicting amputation and the need for multiple debridements in treating this injury.Methods: A historic cohort study of 321 patients treated for tooth knuckle injuries was undertaken. Twenty-one demographic, clinical and laboratory variables were collected. Two outcome measurements were collected - the need for amputation and the need for more than one surgical debridement. A multivariate logistic regression was performed to determine the relationship between the predictor variables and the outcome measurements.Results: Of the 321 patients examined, 1.6% required amputations and 25% required multiple debridements. Osteomyelitis was found to be a major predictor for amputation in these patients (OR = 35). Delayed presentation (OR = 1.1) and diabetes (OR = 2.6) were found to significantly increase the risk of requiring multiple debridements.Conclusions: Our models were able to predict what patients were at the greatest risk for amputation and multiple debridement. Reducing rates of osteomyelitis and delays in presentation may help reduce the incidence of amputation and reoperation in this injury.

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“…The CSF, which was under normal pressure, contained 68 WBCs per cubic millimeter, of COMMENT Since Eiken's original description1 of an anaerobic Gram-negative bacil¬ lus that grew in colonies and pitted the underlying agar, E corrodens has been isolated as normal flora from the oral cavity, upper portion of the air¬ way, and lower GI and female genital tracts. 2 Curiously, E corrodens is only infrequently recognized as a pathogen. Of 140,000 cultures reported from the Boston City Hospital,3 only 72 were of E corrodens; of these, one was in pure culture, and the remainder were part of mixed flora.…”

Section: Report Of a Casementioning

confidence: 99%