Isolation of Hantaan Virus, the Etiologic Agent of Korean Hemorrhagic Fever, from Wild Urban Rats

Lee, Ho Wang; Baek, Luck Ju; Johnson, Karl M.

doi:10.1093/infdis/146.5.638

Cited by 297 publications

(159 citation statements)

References 15 publications

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“…For P. californicus specimens harbouring ILV, amplification of the ILV genome was difficult, especially using M segment primers. This could reflect lower replicative capacity of hantaviruses in secondary hosts, as has been noted previously in experimental hantavirus infections (Lee et al, 1982b;Kawamura et al, 1991).…”

Section: Prospect Hill Virus (Ph) Was Isolated From a Meadow Vole (Misupporting

confidence: 52%

Isla Vista virus: a genetically novel hantavirus of the California vole Microtus californicus

Song

Torrez‐Martinez

Irwin

et al. 1995

Journal of General Virology

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Section: Prospect Hill Virus (Ph) Was Isolated From a Meadow Vole (Misupporting

confidence: 52%

Isla Vista virus: a genetically novel hantavirus of the California vole Microtus californicus

Song

Torrez‐Martinez

Irwin

et al. 1995

Journal of General Virology

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“…We found that HOKV RNA can be maintained in several organs of M. rufocanus, such as lung, spleen, kidney, and blood clots, as seen in other hantaviruses (30,31,42). In particular, HOKV appears to replicate well in lung and spleen.…”

Section: Infection Of Hokkaido Virus In Myodes Rufocanussupporting

confidence: 51%

Mode of Infection of Hokkaido Virus (Genus Hantavirus) among Grey Red‐Backed Voles, Myodes rufocanus, in Hokkaido, Japan

Daud

Kariwa

Tanikawa

et al. 2007

Microbiology and Immunology

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Hokkaido virus (HOKV) is a member of the genus Hantavirus, in the family Bunyaviridae. To investigate HOKV infection in the host Myodes rufocanus, the grey red‐backed vole, 199 animals were captured at Tobetsu (October 2004 and July 2005) and Nakagawa (October 2004) in Hokkaido, Japan, for detection of antibody, antigen, and viral RNA. In the surveys in Tobetsu (2004) and Nakagawa (2004), seropositive animals were detected at a frequency of 6.0% (5/84) and 10.4% (5/48), respectively. No seropositive animals were detected in Tobetsu in 2005. Seroprevalence in males in Tobetsu and Nakagawa in 2004 was 25% (1/4) and 45.5% (5/11), respectively, which was higher than in females, at 5.0% (4/80) and 0% (0/37), respectively (P<0.01). These results suggest that male animals play an important role in the maintenance of HOKV in M. rufocanus. Two females were seronegative but viral RNA‐positive, indicating that these animals had acute infections before antibody was produced. Another five infected animals in Nakagawa were all male and had high levels of antibodies and viral RNA, suggesting that they had persistent infections. Viral RNA copies in organs of infected animals in Nakagawa were quantified by real‐time polymerase chain reaction. Two acutely infected animals had ≥10 times the number of RNA copies in their lungs compared to those of persistently infected animals. In most cases, lungs or spleen had the highest RNA copy number, regardless of infection status.

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“…As was found for Hantaan virus infection of Apodemus, experimentally inoculated and wild-caught Seoul-virus-infected rats excrete virus in urine; however, virus shedding is not consistently observed 20 . Although both naturally and experimentally infected rats have viral antigen in many of their tissues and organs, with lungs generally having the highest antigen concentration 13,20 , the duration of Seoul virus persistence is poorly defined. In separate studies, newborn rats were found to have viral antigen in their organs for at least 25 weeks 13 and adult rats for at least 75 days 20 after infection ( Table 2).…”

Section: Seoul Virusmentioning

confidence: 73%

Persistent hantavirus infections: characteristics and mechanisms

Meyer

Schmaljohn

2000

Trends in Microbiology

188

156

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Isolation of Hantaan Virus, the Etiologic Agent of Korean Hemorrhagic Fever, from Wild Urban Rats

Cited by 297 publications

References 15 publications

Isla Vista virus: a genetically novel hantavirus of the California vole Microtus californicus

Isla Vista virus: a genetically novel hantavirus of the California vole Microtus californicus

Mode of Infection of Hokkaido Virus (Genus Hantavirus) among Grey Red‐Backed Voles, Myodes rufocanus, in Hokkaido, Japan

Persistent hantavirus infections: characteristics and mechanisms

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