Isolation of herpes simplex virus type 1 in recurrent (Mollaret) meningitis

Steel, John; Dix, Richard D.; Baringer, J. Richard

doi:10.1002/ana.410110104

Cited by 78 publications

(19 citation statements)

References 26 publications

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“…Mollaret’s meningitis is rare – only 32 cases were reported in 1982, the same year that the herpes virus was inculpated in a case report [6]. It is characterized by recurrent attacks of sudden onset meningitis that usually last for 2–7 days, with complete recovery but unpredictable recurrences.…”

Section: Mollaret’s Meningitismentioning

confidence: 99%

Mollaret’s Meningitis

Pearce

2008

Eur Neurol

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Pierre Mollaret is mainly known for his contributions to infectious diseases and their prevention. He also described benign, recurrent endothelio-leukocytic meningitis in three patients who had short-lived recurrent attacks of fever, headache and vomiting caused by sterile meningitis, with ‘fantomes cellulaires’ (cell ghosts) in the cerebrospinal fluid. Identical symptoms are caused by Herpes simplex virus-2 and other viruses. The term Mollaret’s meningitis should be restricted to idiopathic recurrent aseptic meningitis. This paper briefly outlines the syndrome and its discoverer.

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Section: Mollaret’s Meningitismentioning

confidence: 99%

Mollaret’s Meningitis

Pearce

2008

Eur Neurol

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“…Chronic suppressive therapy should also be considered for those individuals whose HSV recurrences are associated with serious (and occasionally life-threatening) systemic complications, such as erythema multiforme (4,5,21), recurrent aseptic meningitis (53), and eczema herpeticum (27,63).…”

Section: Other Clinical Settings For Suppressive Acvmentioning

confidence: 99%

Acyclovir prophylaxis for herpes simplex virus infection

Gold¹,

Corey²

1987

Antimicrob Agents Chemother

101

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ACV is an effective agent for the treatment and prophylaxis of HSV infections in both IC and immunologically normal individuals. The drug is well tolerated in both populations and is not significantly associated with clinical or laboratory toxicities. Because of the great potential benefit and low risk, organ transplant recipients and patients with hematologic malignancies undergoing induction chemotherapy should be screened routinely for HSV antibodies; seropositive individuals should receive prophylactic ACV during the period of most profound immunosuppression. Immunologically normal individuals with frequently recurring genital HSV or serious complications associated with outbreaks are candidates for long-term suppression with ACV.

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“…The unknown aetiology of Mollaret's meningitis was first questioned by Steel et al in 1981. They were the first to isolate HSV-1 in the CSF of a patient with diagnosed Mollaret's meningitis [6], suggesting a viral aetiology of the syndrome.…”

Section: Discussionmentioning

confidence: 99%

“…They were the first to isolate HSV-1 in the CSF of a patient with diagnosed Mollaret's meningitis [6], suggesting a viral aetiology of the syndrome. However, it was not until the development and the use of the PCR technique that the Mollaret's meningitis aetiology became clearer.…”

Section: Discussionmentioning

confidence: 99%

A case of recurrent benign lymphocytic (Mollaret's) meningitis and review of the literature

Poulikakos

Sergi

Margaritis

et al. 2010

Journal of Infection and Public Health

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Mollaret's meningitis is a rare form of benign recurrent aseptic meningitis first described in 1944. We report a case of Mollaret's meningitis due to Herpes Simplex Virus type 2 (HSV2), diagnosed with Polymerase Chain Reaction (PCR) implementation in the Cerebrospinal fluid (CSF) of the patient and treated successfully with acyclovir. To our knowledge, this is the first case of Mollaret's meningitis reported in Greece. We reviewed the literature since PCR has become widely available. Herpes Simplex Virus type 2 has been the most commonly identified causative agent of Mollaret's meningitis.

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Isolation of herpes simplex virus type 1 in recurrent (Mollaret) meningitis

Cited by 78 publications

References 26 publications

Mollaret’s Meningitis

Mollaret’s Meningitis

Acyclovir prophylaxis for herpes simplex virus infection

A case of recurrent benign lymphocytic (Mollaret's) meningitis and review of the literature

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