Isolation of human islets and β-cells for pharmacological studies

Swift, S. M.; James, R F; London, N.J.M.

doi:10.1046/j.1463-1326.1999.00016.x

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The Correlation Of Katp Channel Defects With Phhi1

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2000

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“…There are perhaps two reasons. Firstly, it is technically difficult to isolate β‐cells from human tissue[82]. Secondly, the amounts of tissue actually available for experimental studies following processing of the pancreas are diminishingly small.…”

Section: The Correlation Of Katp Channel Defects With Phhimentioning

confidence: 99%

Ions, genes and insulin release: from basic science to clinical disease Based on the 1998 R. D. Lawrence Lecture

Mj¹

2000

Diabetic Medicine

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In 1968, reports of the first microelectrode recordings of insulin-secreting cells were published. Thirty years later it is now established that electrical responses of beta-cells play a critical role in stimulus-secretion coupling. It is now also clear that defects in ion channel genes compromise the mechanisms which govern secretion and lead to the onset of disease. Here, the physiology of insulin release is reviewed in the context of ion channels, the ionic control of insulin release and the pathophysiology of hyperinsulinism of infancy.

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Section: The Correlation Of Katp Channel Defects With Phhimentioning

confidence: 99%

Ions, genes and insulin release: from basic science to clinical disease Based on the 1998 R. D. Lawrence Lecture

Mj¹

2000

Diabetic Medicine

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Current Awareness

2000

Diabetes Metab. Res. Rev.

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In order to keep subscribers up-to-date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of diabetes/metabolism. Each bibliography is divided into 17 sections: 1 Books, Reviews & Symposia; 2 General; 3 Genetics; 4 Epidemiology; 5 Immunology; 6 Prediction; 7 Prevention; 8 Intervention: a&rpar General; b&rpar Pharmacology; 9 Pathology: a&rpar General; b&rpar Cardiovascular; c&rpar Neurological; d&rpar Renal; 10 Endocrinology & Metabolism; 11 Nutrition; 12 Animal Studies; 13 Techniques. Within each section, articles are listed in alphabetical order with respect to author (8 Weeks journals - Search completed at 19th Apr. 2000)

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Isolation of human islets and β-cells for pharmacological studies

Cited by 2 publications

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Ions, genes and insulin release: from basic science to clinical disease Based on the 1998 R. D. Lawrence Lecture

Ions, genes and insulin release: from basic science to clinical disease Based on the 1998 R. D. Lawrence Lecture

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