Isolation of<i>Bordetella avium</i>and Novel<i>Bordetella</i>Strain from Patients with Respiratory Disease

Harrington, Amanda; Castellanos, Jaime A.; Ziedalski, Tomasz M.; Clarridge, Jill E.; Cookson, Brad T.

doi:10.3201/eid1501.071677

Cited by 52 publications

(22 citation statements)

References 6 publications

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“…Among rep-resentative species, B. pertussis is the causative agent of whooping cough (pertussis), and B. parapertussis and B. bronchiseptica have also been implicated in respiratory tract infections in humans. The present species, B. holmesii, was also recently reported to have been detected in patients with pertussis-like respiratory syndrome (6,15). The other species, Bordetella avium, Bordetella hinzii, and Bordetella petrii, are rarely detected in respiratory samples from patients with chronic respiratory infectious diseases, including cystic fibrosis (4,15,18).…”

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confidence: 52%

First Report of Infectious Pericarditis Due to Bordetella holmesii in an Adult Patient with Malignant Lymphoma

et al. 2012

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Bordetella holmesii is a fastidious Gram-negative rod first identified in 1995. Though rare, it is isolated mainly in immunocompromised and asplenic hosts and is associated with bacteremia, pertussis-like respiratory tract infection, and endocarditis. Herein, we describe a unique B. holmesii infectious pericarditis patient with malignant lymphoma. CASE REPORTA 71-year-old male was hospitalized because of fever and dyspnea on effort. He had received 8 cycles of chemotherapy for malignant lymphoma (diffuse large B cell lymphoma) over the prior year, but complete remission was not achieved. Because of a persistent lesion, we initiated maintenance therapy, including rituximab administration which was continued until the present hospitalization. Approximately 2 weeks prior to presentation, he complained of dyspnea on effort and a rising low-grade fever. Follow-up computed tomography (CT) suggested pericardial effusion (Fig. 1A), and pleural change was suspected (Fig. 1B). He was thus admitted under a diagnosis of possible pericarditis. Clinical examination findings on presentation were unremarkable other than a temperature of 37.5°C. Initial laboratory investigations revealed elevations of aspartate aminotransferase (AST) and alanine aminotransaminase (ALT) to 30 and 59 IU/liter, respectively (normal ranges, 10 to 28 and 5 to 33 IU/liter, respectively), an alkaline phosphatase level of 392 IU/liter (normal range, 104 to 338 IU/liter), a hemoglobin level of 11.1 g/dl (normal range, 12 to 18 g/dl), and a C-reactive protein (CRP) level of 22.99 mg/dl (normal value, less than 0.3 mg/dl). The white blood cell count was 6,200/l, i.e., within normal limits. However, the percentage of segmented neutrophils was 86.5% (normal range, 38 to 58%). Serum electrolytes and creatinine were within normal limits. Chest radiographs showed slight cardiomegaly, whereas abdominal radiographs revealed no abnormalities. HBs antigen and anti-hepatitis C antibody were negative.In view of the possibility of pericarditis, he received pericardial drainage therapy and empirical antimicrobial administration (ceftriaxone 2,000 mg/day) upon admission. The pericardial effusion was bloody and contained neutrophil-rich inflammatory cells but no malignant cells. Gram staining was negative. With empirical antimicrobial therapy, his clinical symptoms disappeared and pericardial effusion did not reaccumulate after drain removal. We ultimately removed more than 1,000 ml of pericardial effusion, and culture of approximately 20 ml of this effusion was started. Forty-eight hours after starting the culture, gray, smooth, round colonies less than 1 mm in diameter were isolated from blood agar (Eiken Chemical Co., Tokyo, Japan) (Fig. 2). There was no colony growth at 24 h when bacteria were inoculated onto 5% sheep blood agar plates and incubated in 5% CO 2 under aerobic conditions, whereas they grew after 5 days on MacConkey agar (Oriental Yeast Co., Tokyo, Japan). Isolates were small Gram-negative coccobacilli on microscopic observation, and no motility was seen...

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confidence: 52%

First Report of Infectious Pericarditis Due to Bordetella holmesii in an Adult Patient with Malignant Lymphoma

et al. 2012

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“…Bordetella pertussis is the causative agent of whooping cough, while Bordetella parapertussis and Bordetella bronchiseptica are also implicated in respiratory tract infections in humans. Bordetella avium is considered a strict avian pathogen but has recently been isolated in the sputum of cystic fibrosis patients and others with respiratory disease (9,19). Bordetella hinzii was found to colonize the respiratory tract in poultry and also in humans with cystic fibrosis.…”

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confidence: 99%

Bordetella holmesii Bacteremia in Asplenic Children: Report of Four Cases Initially Misidentified as Acinetobacter lwoffii

et al. 2010

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Bordetella holmesii is a fastidious Gram-negative rod that was initially identified in 1995. It causes bacteremia, predominantly among patients with anatomical or functional asplenia. We report four cases of B. holmesii bacteremia in asplenic children occurring within the last 4 years. In all cases, B. holmesii was misidentified by an automated system as Acinetobacter lwoffii.

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“…and chronic granulomatous disease (Burkholderia cepacia complex spp.) (5,6,9,14). Members of the Burkholderiales have not been previously described in association with gastrointestinal disease.…”

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NovelBurkholderiales23S rRNA Genes Identified in Ileal Biopsy Samples from Children: Preliminary Evidence that a Subtype Is Associated with Perianal Crohn's Disease

et al. 2010

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A novel family of Burkholderiales bacteria was identified in ileal biopsy specimens from children presenting with symptoms of inflammatory bowel disease. A molecular subtyping approach based on sequencing of a variable region of the bacteria's 23S rRNA genes identified three variants. Pilot analysis identified one variant to be significantly associated with perianal Crohn's disease.

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Isolation ofBordetella aviumand NovelBordetellaStrain from Patients with Respiratory Disease

Cited by 52 publications

References 6 publications

First Report of Infectious Pericarditis Due to Bordetella holmesii in an Adult Patient with Malignant Lymphoma

First Report of Infectious Pericarditis Due to Bordetella holmesii in an Adult Patient with Malignant Lymphoma

Bordetella holmesii Bacteremia in Asplenic Children: Report of Four Cases Initially Misidentified as Acinetobacter lwoffii

NovelBurkholderiales23S rRNA Genes Identified in Ileal Biopsy Samples from Children: Preliminary Evidence that a Subtype Is Associated with Perianal Crohn's Disease

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