Isolation of Influenza C Virus from Pigs and Experimental Infection of Pigs with Influenza C Virus

Guo, Yuhe; Fengen, Jin; Wang, Ping; Wang, Min; Jiming, Zhu

doi:10.1099/0022-1317-64-1-177

Cited by 105 publications

(43 citation statements)

References 3 publications

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“…The infection is considered common based on high seroprevalence [3,4,5]. The influenza C virus has also been found in pigs, and there are some reports about interspecies transmission of the virus between humans and pigs [6,7]. However, pigs are not considered to play a significant role in the transmission cycle of the viruses in humans [7,8].…”

Section: Introductionmentioning

confidence: 99%

Analyses of Evolutionary Characteristics of the Hemagglutinin-Esterase Gene of Influenza C Virus during a Period of 68 Years Reveals Evolutionary Patterns Different from Influenza A and B Viruses

Furuse

Matsuzaki

Nishimura

et al. 2016

Viruses

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Infections with the influenza C virus causing respiratory symptoms are common, particularly among children. Since isolation and detection of the virus are rarely performed, compared with influenza A and B viruses, the small number of available sequences of the virus makes it difficult to analyze its evolutionary dynamics. Recently, we reported the full genome sequence of 102 strains of the virus. Here, we exploited the data to elucidate the evolutionary characteristics and phylodynamics of the virus compared with influenza A and B viruses. Along with our data, we obtained public sequence data of the hemagglutinin-esterase gene of the virus; the dataset consists of 218 unique sequences of the virus collected from 14 countries between 1947 and 2014. Informatics analyses revealed that (1) multiple lineages have been circulating globally; (2) there have been weak and infrequent selective bottlenecks; (3) the evolutionary rate is low because of weak positive selection and a low capability to induce mutations; and (4) there is no significant positive selection although a few mutations affecting its antigenicity have been induced. The unique evolutionary dynamics of the influenza C virus must be shaped by multiple factors, including virological, immunological, and epidemiological characteristics.

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Section: Introductionmentioning

confidence: 99%

Analyses of Evolutionary Characteristics of the Hemagglutinin-Esterase Gene of Influenza C Virus during a Period of 68 Years Reveals Evolutionary Patterns Different from Influenza A and B Viruses

Furuse

Matsuzaki

Nishimura

et al. 2016

Viruses

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“…New reassortants from swine can spread and be transmitted to and among humans, causing influenza epidemics or pandemics, was as seen with the H1N1 pandemic of 2009 [19]. In contrast, influenza B (IBV) and C (ICV) viruses mainly exist in humans, although influenza B infection of seals and influenza C infection of pigs have been reported previously [9, 15]. …”

Section: Introductionmentioning

confidence: 99%

Genomic and evolutionary characterization of a novel influenza-C-like virus from swine

et al. 2013

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We recently described the isolation of a novel influenza virus from swine exhibiting respiratory disease in the United States that is distantly related to human influenza C virus. Based on genetic, biochemical and morphological analysis, the virus was provisionally classified as C/swine/Oklahoma/1334/2011 (C/OK). To further understand the genetics and evolution of this novel pathogen, we performed a comprehensive analysis of its sequence and phylogeny. The results demonstrated that C/OK and human influenza C viruses share a conserved array of predicted functional domains in the viral RNA genome replication and viral entry machinery but vary at key functional sites. Furthermore, our evolutionary analysis showed that homologous genes of C/OK and human influenza C viruses diverged from each other an estimated several hundred to several thousand years ago. Taken together, the findings described in this study support and extend our previous observations that C/OK is a genetically and evolutionarily distinct influenza virus in the family Orthomyxoviridae.

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“…Influenza B viruses naturally infect humans, and occasionally seals, and cause more limited epidemics than Influenza A viruses in humans every few years (3). Influenza C viruses infect humans and pigs (4). Seroepidemiological studies suggest that influenza C virus has been globally distributed, although it is clinically benign in humans (5).…”

Section: Introductionmentioning

confidence: 99%

Structure of influenza virus ribonucleoprotein complexes and their packaging into virions

Noda

Kawaoka

2010

Reviews in Medical Virology

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Summary The influenza A virus genome consists of eight segmented, single-stranded, negative-sense RNAs. Each viral RNA (vRNA) segment forms a ribonucleoprotein complex (RNP) together with nucleoproteins and a polymerase complex, which is a fundamental unit for transcription and replication of the viral genome. Although the exact structure of the intact RNP remains poorly understood, recent electron microscopic studies have revealed certain structural characteristics of the RNP. This review focuses on the findings of these various electron microscopic analyses of RNPs extracted from virions and RNPs inside virions. Based on the morphological and structural observations, we present the architecture of RNPs within a virion and discuss the genome packaging mechanism by which the vRNA segments are incorporated into virions.

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Isolation of Influenza C Virus from Pigs and Experimental Infection of Pigs with Influenza C Virus

Cited by 105 publications

References 3 publications

Analyses of Evolutionary Characteristics of the Hemagglutinin-Esterase Gene of Influenza C Virus during a Period of 68 Years Reveals Evolutionary Patterns Different from Influenza A and B Viruses

Analyses of Evolutionary Characteristics of the Hemagglutinin-Esterase Gene of Influenza C Virus during a Period of 68 Years Reveals Evolutionary Patterns Different from Influenza A and B Viruses

Genomic and evolutionary characterization of a novel influenza-C-like virus from swine

Structure of influenza virus ribonucleoprotein complexes and their packaging into virions

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