Isolation of Lignans from The Stem Bark of Willughbeia coriacea and Their Cytotoxic Activity

Abstract

Willughbeia coricea Wall is a herbal medicine to treat diarrhea in Dayak People, Kalimantan, Indonesia. This study aims to determine the structure of the lignans and their anticancer activity against cervical cancer cells (HeLa). Two lignan derivatives, (+)-pinoresinol (1) and alyterinate A (2), were isolated from the roots of the W. coricea Wall. The structures of 1 and 2 were determined based on UV, IR, HRESIMS, 1D (1H and 13C), and 2D NMR (HMQC and HMBC) spectroscopic analysis. Compounds 1-2 showed moderate activity against HeLa cells with an IC50 value of 10.1 and 12.5 μM, respectively.