2023
DOI: 10.1111/micc.12800
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Isolation of lymph shows dysregulation of STAT3 and CREB pathways in the spleen and liver during leukemia development in a rat model

Abstract: Background and aims Acute myeloid leukemia (AML) is a heterogeneous malignant condition characterized by massive infiltration of poorly differentiated white blood cells in the blood stream, bone marrow, and extramedullary sites. During leukemic development, hepatosplenomegaly is expected to occur because large blood volumes are continuously filtered through these organs. We asked whether infiltration of leukemic blasts initiated a response that could be detected in the interstitial fluid phase of the spleen an… Show more

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“…The study by Mahamud et al 5 shows that transcription factor GATA2 promotes blood/lymph separation through platelets and that while lymphovenous valves are the only known sites of interaction between blood and lymphatic vessels, more unidentified sites of interaction possibly exist between blood and lymphatic vessels. Steinskog et al 6 used a rat model mimicking acute myeloid leukemia (AML) with cannulation of efferent lymphatic vessels from the spleen and liver and subsequent proteomic profiling. Their findings revealed a differential response in AML‐cell infiltrated spleen and liver, indicating that interstitial fluid and efferent lymph can provide unique information about the specific microenvironment responses that are variable in target organs during AML progression.…”
mentioning
confidence: 99%
“…The study by Mahamud et al 5 shows that transcription factor GATA2 promotes blood/lymph separation through platelets and that while lymphovenous valves are the only known sites of interaction between blood and lymphatic vessels, more unidentified sites of interaction possibly exist between blood and lymphatic vessels. Steinskog et al 6 used a rat model mimicking acute myeloid leukemia (AML) with cannulation of efferent lymphatic vessels from the spleen and liver and subsequent proteomic profiling. Their findings revealed a differential response in AML‐cell infiltrated spleen and liver, indicating that interstitial fluid and efferent lymph can provide unique information about the specific microenvironment responses that are variable in target organs during AML progression.…”
mentioning
confidence: 99%