“…The study by Mahamud et al 5 shows that transcription factor GATA2 promotes blood/lymph separation through platelets and that while lymphovenous valves are the only known sites of interaction between blood and lymphatic vessels, more unidentified sites of interaction possibly exist between blood and lymphatic vessels. Steinskog et al 6 used a rat model mimicking acute myeloid leukemia (AML) with cannulation of efferent lymphatic vessels from the spleen and liver and subsequent proteomic profiling. Their findings revealed a differential response in AML‐cell infiltrated spleen and liver, indicating that interstitial fluid and efferent lymph can provide unique information about the specific microenvironment responses that are variable in target organs during AML progression.…”