2022
DOI: 10.25122/jml-2020-0129
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Isolation of megakaryocytes using magnetic cell separation and adverse effects induced by diclofenac toxicity in an experiment

Abstract: This study investigates the response of bone marrow (particularly megakaryocytes) in mice under the influence of diclofenac sodium for 10 days using intraperitoneal injection at various doses. A fundamentally new immunomagnetic separation method was applied during the experiment, which helped obtain pure lines of bone marrow cells, particularly megakaryocytes (MC), without admixtures of other cells or their particles. The resulting cells completely retain their structure and can be used in further research. Th… Show more

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