Isolation of methyl syringate as a specific aflatoxin production inhibitor from the essential oil of Betula alba and aflatoxin production inhibitory activities of its related compounds

Jermnak, Usuma; Yoshinari, Tomoya; Sugiyama, Yasumasa; Tsuyuki, Rie; Nagasawa, Hiromichi; Sakuda, Shohei

doi:10.1016/j.ijfoodmicro.2011.11.023

Cited by 42 publications

(39 citation statements)

References 20 publications

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“…Methyl syringate is a plant phenolic compound in Aspergillus flavus, Aspergillus parasiticus, Betula alba, Kunzea ericoides (kanuka) honeys, and Leptospermum scoparium (manuka) and has several functions as a superoxide scavenger, an effective laccase mediator, and an inhibitor of aflatoxin production [27]–[29]. However, the effects of methyl syringate on gastric functions remain unexplored.…”

Section: Discussionmentioning

confidence: 99%

The TRPA1 Agonist, Methyl Syringate Suppresses Food Intake and Gastric Emptying

et al. 2013

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Transient receptor potential channel ankryn 1 (TRPA1) expressed in the gastrointestinal tract is associated with gastric motility, gastric emptying, and food intake. In this study, we investigated the effects of methyl syringate, a specific and selective TRPA1 agonist, on food intake, gastric emptying, and gut hormone levels in imprinting control region (ICR) mice. The administration of methyl syringate suppressed cumulative food intake and gastric emptying. In addition, treatment with ruthenium red (RR), a general cation channel blocker, and HC-030031, a selective TRPA1 antagonist, inhibited methyl syringate-induced reduction of food intake and delayed gastric emptying in ICR mice. Methyl syringate also increased plasma peptide YY (PYY) levels, but not glucagon-like peptide-1 (GLP-1) levels. The elevation in PYY was blocked by treatment with RR and HC-030031. The present findings indicate that methyl syringate regulates food intake and gastric emptying through a TRPA1-mediated pathway and, by extension, can contribute to weight suppression.

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Section: Discussionmentioning

confidence: 99%

The TRPA1 Agonist, Methyl Syringate Suppresses Food Intake and Gastric Emptying

et al. 2013

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“…Additionally, specific aflatoxin-production inhibitors, which do not significantly affect fungal growth, may be useful for the control and prevention of aflatoxin contamination in food and feed without incurring a rapid spread of resistant strains. To date, some pesticides [6], microbial metabolites [7], and plant constituents [8,9] have been shown to be specific aflatoxin-production inhibitors.…”

Section: Introductionmentioning

confidence: 99%

Inhibitory Effects of Respiration Inhibitors on Aflatoxin Production

Sakuda

Prabowo

Takagi

et al. 2014

Toxins

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Aflatoxin production inhibitors, which do not inhibit the growth of aflatoxigenic fungi, may be used to control aflatoxin without incurring a rapid spread of resistant strains. A respiration inhibitor that inhibits aflatoxin production was identified during a screening process for natural, aflatoxin-production inhibitors. This prompted us to evaluate respiration inhibitors as potential aflatoxin control agents. The inhibitory activities of four natural inhibitors, seven synthetic miticides, and nine synthetic fungicides were evaluated on aflatoxin production in Aspergillus parasiticus. All of the natural inhibitors (rotenone, siccanin, aptenin A5, and antimycin A) inhibited fungal aflatoxin production with IC50 values around 10 µM. Among the synthetic miticides, pyridaben, fluacrypyrim, and tolfenpyrad exhibited strong inhibitory activities with IC50 values less than 0.2 µM, whereas cyflumetofen did not show significant inhibitory activity. Of the synthetic fungicides, boscalid, pyribencarb, azoxystrobin, pyraclostrobin, and kresoxim-methyl demonstrated strong inhibitory activities, with IC50 values less than 0.5 µM. Fungal growth was not significantly affected by any of the inhibitors tested at concentrations used. There was no correlation observed between the targets of respiration inhibitors (complexes I, II, and III) and their IC50 values for aflatoxin-production inhibitory activity. This study suggests that respiration inhibitors, including commonly used pesticides, are useful for aflatoxin control.

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“…Evidence suggests that its aflatoxin production inhibitory activity may correlate with its strong antioxidant activity [82]. Transgenic plants with elevated levels of gallic acid that suppress aflatoxin production have been created [88]. Many essential oils obtained from parts of higher plants have also been shown to possess antiaflatoxigenic properties [89].…”

Section: Aflatoxin Production Inhibitionmentioning

confidence: 99%

Natural Products for Preventing and Controlling Aflatoxin Contamination of Food

Tian¹,

Chun²

2017

Aflatoxin-Control, Analysis, Detection and Health Risks

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Aflatoxins are the most potent naturally occurring toxin and liver carcinogens known and their contamination of food is a significant risk factor for human health. Conventional chemical and physical approaches have been insufficient to eliminate aflatoxins from food, and the application of synthetic compounds can give rise to notable drug resistance and serious environmental and health problems. Awareness of these problems has led to an urgent need to identify safer alternative strategies. There are various natural compounds that influence aflatoxin contamination of food in different ways, including by inhibiting the growth of aflatoxigenic fungi, blocking aflatoxin biosynthesis, and removing or degrading aflatoxins. These inhibitors, many of which have shown great potentials for the control of aflatoxin contamination, have great promise for the development of new approaches to combatting aflatoxin contamination, and are capable of replacing or complementing conventional strategies. While more and more natural inhibitors are being identified, the modes of action of most of these are poorly understood. Further studies are necessary to better understand the mechanism of action of these compounds before their widespread commercial use. The objective of this chapter is to present the results of studies of the control of aflatoxin contamination using natural products.

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Isolation of methyl syringate as a specific aflatoxin production inhibitor from the essential oil of Betula alba and aflatoxin production inhibitory activities of its related compounds

Cited by 42 publications

References 20 publications

The TRPA1 Agonist, Methyl Syringate Suppresses Food Intake and Gastric Emptying

The TRPA1 Agonist, Methyl Syringate Suppresses Food Intake and Gastric Emptying

Inhibitory Effects of Respiration Inhibitors on Aflatoxin Production

Natural Products for Preventing and Controlling Aflatoxin Contamination of Food

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