Isolation of new compound and neuroprotective studies from Dodonaea viscosa

Siddiqui, Nasir A.; Almarfadi, Omer M.; Shahat, Abdelaaty A.; Alqahtani, Ali S.; Gamal, Ali A. El; Raish, Mohammed; Iqbal, Muzaffar

doi:10.1016/j.jksus.2023.102704

Cited by 2 publications

(2 citation statements)

References 45 publications

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“…It was native to Australia but later became widespread throughout tropical regions. In Saudi Arabia, D. viscosa grows tremendously in the South-western and Eastern Provinces and Hijaz region ( Siddiqui et al, 2023 ). It contains a wide range of phytochemicals, including flavonoids, terpenoids, saponins, sterols, phenolics, sugars, alkaloids, and tannins ( Hossain, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Isolation of a novel isoprenylated phenolic compound and neuroprotective evaluation of Dodonaea viscosa extract against cerebral ischaemia–reperfusion injury in rats

Almarfadi,

Siddiqui,

Shahat

et al. 2024

Saudi Pharmaceutical Journal

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Section: Introductionmentioning

confidence: 99%

Isolation of a novel isoprenylated phenolic compound and neuroprotective evaluation of Dodonaea viscosa extract against cerebral ischaemia–reperfusion injury in rats

Almarfadi,

Siddiqui,

Shahat

et al. 2024

Saudi Pharmaceutical Journal

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“…Dodonaea viscosa Jacq. (plant DV) has antioxidant (Alanazi et al, 2023), antidiabetic (Malik et al, 2022), anti-inflammatory (Siddiqui et al, 2023), anticholinesterase (Muhammad et al, 2016), and cytotoxic activities (Herrera-Calderon et al, 2023), but detailed screening of the enzymatic and non-enzymatic antioxidant phytochemicals remains to be explored.…”

Section: Introductionmentioning

confidence: 99%

In vitro and in vivo antioxidant therapeutic evaluation of phytochemicals from different parts of Dodonaea viscosa Jacq

Khan,

Rehman,

Khan

et al. 2023

Front. Chem.

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Introduction: Natural antioxidants are vital to promote health and treat critical disease conditions in the modern healthcare system. This work adds to the index of natural medicines by exploring the antioxidant potential of Dodonaea viscosa Jacq. (Plant-DV).Material and Methods: The aqueous extract of leaves and flower-containing seeds from plant-DV in freshly prepared phosphate buffer is evaluated for antioxidant potential. In vitro antioxidant potential of the nascent and oxidatively stressed extracts was analyzed through glutathione (GSH) assay, hydrogen peroxide (H2O2) scavenging effect, glutathione-S-transferase (GST) assay, and catalase (CAT) activity. In vivo therapeutic assessment is performed in Wistar Albino rats using vitamin C as a positive control. The livers and kidneys of individual animals are probed for glutathione, glutathione-S-transferase, and catalase activities.Results: flower-containing seeds have GSH contents (59.61 µM) and leaves (32.87 µM) in the fresh aqueous extracts. The hydrogen peroxide scavenging effect of leaves is superior to flower-containing seeds with 17.25% and 14.18% respectively after 30 min incubation. However, oxidatively stressed extracts with Ag(I) and Hg(II) show declining GSH and GST levels. The plant extracts are non-toxic in rats at 5000 mg/Kg body weight. Liver and kidneys homogenate reveal an increase in GSH, GST, and CAT levels after treatment with 150 ± 2 mg/kg and 300 ± 2 mg/kg body weight plant extract compared with normal saline-treated negative and vitamin C treated positive control.Discussion: The crude aqueous extracts of leaves and flower-containing seeds of plant-DV show promising antioxidant potential both in in vitro and in vivo evaluation.

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Isolation of new compound and neuroprotective studies from Dodonaea viscosa

Cited by 2 publications

References 45 publications

Isolation of a novel isoprenylated phenolic compound and neuroprotective evaluation of Dodonaea viscosa extract against cerebral ischaemia–reperfusion injury in rats

Isolation of a novel isoprenylated phenolic compound and neuroprotective evaluation of Dodonaea viscosa extract against cerebral ischaemia–reperfusion injury in rats

In vitro and in vivo antioxidant therapeutic evaluation of phytochemicals from different parts of Dodonaea viscosa Jacq

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