Isolation of Nile crocodile (Crocodylus niloticus) serum immunoglobulin M and Y (IgM and IgY)

Abdool, Faiaz Shaik; Coetzer, Theresa H.T.; Goldring, J.P. Dean

doi:10.1016/j.jim.2019.112724

Cited by 3 publications

(1 citation statement)

References 51 publications

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“…A common difficulty in the development ELISA and similar assays is the limited availability of either broadly reactive or species-specific anti-reptile immunoglobulins, leaving researchers to develop reagents for their species of interest ( 90 , 91 ) or design assays to avoid the requirement of such reagents. HI tests and VNTs do not suffer from these limitations but usually require whole virus and for VNTs appropriate cell cultures as well as an isolate.…”

Section: Laboratory Diagnosismentioning

confidence: 99%

Nidoviruses in Reptiles: A Review

et al. 2021

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Since their discovery in 2014, reptile nidoviruses (also known as serpentoviruses) have emerged as significant pathogens worldwide. They are known for causing severe and often fatal respiratory disease in various captive snake species, especially pythons. Related viruses have been detected in other reptiles with and without respiratory disease, including captive and wild populations of lizards, and wild populations of freshwater turtles. There are many opportunities to better understand the viral diversity, species susceptibility, and clinical presentation in different species in this relatively new field of research. In captive snake collections, reptile nidoviruses can spread quickly and be associated with high morbidity and mortality, yet the potential disease risk to wild reptile populations remains largely unknown, despite reptile species declining on a global scale. Experimental studies or investigations of disease outbreaks in wild reptile populations are scarce, leaving the available literature limited mostly to exploring findings of naturally infected animals in captivity. Further studies into the pathogenesis of different reptile nidoviruses in a variety of reptile species is required to explore the complexity of disease and routes of transmission. This review focuses on the biology of these viruses, hosts and geographic distribution, clinical signs and pathology, laboratory diagnosis and management of reptile nidovirus infections to better understand nidovirus infections in reptiles.

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Section: Laboratory Diagnosismentioning

confidence: 99%

Nidoviruses in Reptiles: A Review

et al. 2021

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A single exon-encoded Theileria parva strain Muguga cysteine protease (ThpCP): Molecular modelling and characterisation

2023

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The reptilian perspective on vertebrate immunity: 10 years of progress

Zimmerman

2020

Journal of Experimental Biology

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Ten years ago, ‘Understanding the vertebrate immune system: insights from the reptilian perspective’ was published. At the time, our understanding of the reptilian immune system lagged behind that of birds, mammals, fish and amphibians. Since then, great progress has been made in elucidating the mechanisms of reptilian immunity. Here, I review recent discoveries associated with the recognition of pathogens, effector mechanisms and memory responses in reptiles. Moreover, I put forward key questions to drive the next 10 years of research, including how reptiles are able to balance robust innate mechanisms with avoiding self-damage, how B cells and antibodies are used in immune defense and whether innate mechanisms can display the hallmarks of memory. Finally, I briefly discuss the links between our mechanistic understanding of the reptilian immune system and the field of eco-immunology. Overall, the field of reptile immunology is poised to contribute greatly to our understanding of vertebrate immunity in the next 10 years.

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Isolation of Nile crocodile (Crocodylus niloticus) serum immunoglobulin M and Y (IgM and IgY)

Cited by 3 publications

References 51 publications

Nidoviruses in Reptiles: A Review

Nidoviruses in Reptiles: A Review

A single exon-encoded Theileria parva strain Muguga cysteine protease (ThpCP): Molecular modelling and characterisation

The reptilian perspective on vertebrate immunity: 10 years of progress

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