Isolation of Novel Beauvericin Analogues from the Fungus Beauveria bassiana

Gupta, Sandeep; Montllor, C. B.; Hwang, Yih‐Shen

doi:10.1021/np50119a012

Cited by 94 publications

(51 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Later studies confirmed the existence of toxins produced by species of this genus; Beauvericin, Bassianin, Bassianolide, Beauverolides, and Tenellin from B. bassiana, and Oosporein from Beauveria brongniartii (Ferron 1981;Grove and Pople 1980;Strasser et al, 2000). A dichloromethane extract from mycelium showed activity when assayed against Aedes aegypti larvae at 100 ppm (Gupta et al 1995). This extract contained Beauvericin and two analogues (Beauvericin A and B).…”

Section: Beauveriamentioning

confidence: 88%

Coelomomyces numularius sp. nov. (Blastocladiales: Coelomomycetaceae), a New Fungal Parasite of Anopheles squamosus (Diptera: Culicidae) from Angola, Africa

Ribeiro

Ramos

2000

View full text Add to dashboard Cite

Section: Beauveriamentioning

confidence: 88%

Coelomomyces numularius sp. nov. (Blastocladiales: Coelomomycetaceae), a New Fungal Parasite of Anopheles squamosus (Diptera: Culicidae) from Angola, Africa

Ribeiro

Ramos

2000

View full text Add to dashboard Cite

“…It is studied for the production of beauvericin, the fermentation conditions and techniques are widely accepted and fed-batch method is accepted as the most efficient method. B. bassiana, Fusarium spp., Paecilomyces fumoso-roseus and P. tenuipes are feasible and promising fungi for the production of beauvericin [28][29][30][31][32].…”

Section: Biosynthesis Of Beauvericinmentioning

confidence: 99%

Pharmacological and Therapeutic Potential of Beauvericin: A Short Review

Sood¹,

S²,

Hu$^{³

et al. 2017

J Proteomics Bioinform

View full text Add to dashboard Cite

An entomopathogenic fungus, Beauveria spp. has been known to have numerous pharmacological and therapeutic implications, especially, in terms of human health making it a suitable for ethnopharmacological use. Beauvericin is a cyclic hexadepsipeptide mycotoxin, a novel bio-metabolite derived from this fungus, exhibiting a very potent anticancer, cytotoxic activities, antiplatelet aggregation and antimicrobial activities. The current review discusses the therapeutic potential of beauvericin including pharmacological and biological activities which will certainly draw the attention of scientific community to improve the production of beauvericin for its use in medical fields.

show abstract

“…Moreover, the product ion spectra allowed the comparison of the compounds fragmentation profile to the data found in the literature (Table 1). 24,25,[40][41][42][43][44] The electrospray ionization tandem mass spectra (ESI-MS/MS) and fragmentation mechanism proposal for beauvericin A or F are depicted in Figures 4 and 5, Larvicidal Activity of Beauveria bassiana Extracts against Aedes aegypti and Identification of Beauvericins J. Braz. Chem.…”

Section: Cyclodepsipeptides Fragmentationmentioning

confidence: 99%

“…to Trypanosoma cruzi. 45 Beauvericin has been reported to be toxic on Aedes aegypti larvae with LC 50 26 ppm, 24 and 10 and 20 μg mL -1 showed 39 and 86% of mortality in 48 hours, respectively. 46 The presence of beauvericin, beauvericin A or F, beauvericin E and bassianolide in the extracts of two B. bassiana strains may explain the excellent larvicidal activity observed.…”

Section: Phylogenetic Analysesmentioning

confidence: 99%

“…[21][22][23] It contains three residues each D-2-hydroxyisovaleric acid (Hiv) and L-N-methylphenylalanine linked alternately. Recently, new analogues of beauvericin were described, including beauvericin A, B, 24 D, E and F. 25 Bassianolide is another cyclooctadepsipeptide metabolite produced B. bassiana and Lecanicillium lecanii. 9 It is toxic to insects and probably also acts as an ionophore, such as other cyclodepsipeptides.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Larvicidal Activity of Beauveria bassiana Extracts against Aedes aegypti and Identification of Beauvericins

Daniel

Silva

Nakagawa

et al. 2016

J. Braz. Chem. Soc.

View full text Add to dashboard Cite

Beauveria bassiana is an entomopathogenic fungus that has been well known for its capacity to act as biopesticide on various disease vectors. The analysis of organic extracts of strains CG71 and UNI40 led to identification of cyclodepsipeptides beauvericin, beauvericin A or F, beauvericin E and bassianolide by ultra-high pressure liquid chromatography-high resolution mass spectrometry in tandem mode (UHPLC-HRMS/MS). The larvicidal activity on 3 rd instar of Aedes aegypti revealed LC 50 0.9887 and 0.4653 ppm in 24 and 48 hours (CG71 methanolic extract), LC 50 0.7834 ppm in 48 hours (CG71 ethyl acetate), LC 50 0.7834 and 1.8149 ppm (UNI 40 for ethyl acetate and methanolic extracts, respectively) in 48 hours. These findings highlight the potential of B. bassiana metabolites for controlling the vector of Dengue and Zika diseases. Keywords: cyclohexadepsipeptides, Dengue, Zika, beauvericins, UHPLC-HRMS/MS IntroductionThe entomopathogenic Beauveria bassiana has a broad host range naturally attacking insects and variety of arthropod species. [1][2][3] Due to this ability, it is used as a biopesticide agent on diverse disease vectors, including crop pests, ticks and mosquitoes. 4,5 The attack on insect cuticle occurs after hyphae of B. bassiana penetrate the insect integument by enzymatic action. 6 Species of entomopathogenic fungi have been described as producers of secondary metabolites, including bioactive non-ribosomal peptides and polyketides. 7 B. bassiana produces the cyclooligomer nonribosomal depsipeptides beauvericins and bassianolide, 8,9 beauveriolides, 10 D, E and F. 25 Bassianolide is another cyclooctadepsipeptide metabolite produced B. bassiana and Lecanicillium lecanii. 9 It is toxic to insects and probably also acts as an ionophore, such as other cyclodepsipeptides. 15 The structural diversity of metabolites from entomopathogenic fungi, associated with diverse biological activities, stimulates the research by on bioactive fungal extracts for controlling insect pests and disease vectors.Larvicidal Activity of Beauveria bassiana Extracts against Aedes aegypti and Identification of Beauvericins J. Braz. Chem. Soc. 1004 Dengue is a viral infection transmitted to humans by Aedes aegypti mosquitoes that became a major concern of the public health sector. 26 There were 96 million apparent dengue infections globally in 2010, of which the Americas contributed 14% (13 million infections) of worldwide and over half developed in Brazil and Mexico. 27 Due to no effective antiviral agents and licensed vaccine for infection, the decrease in transmission depends only on vector control by elimination of artificial and disposable water inundated larvae breeding sites and application of insecticides. 27,28 Furthermore, studies reveal resistance in the vector population to various substances, in Brazil there is an irregular distribution of insecticide resistance. 28 Furthermore, Aedes mosquitoes also transmit Zika virus; attracting worldwide attention in 2016, when the vector caused widespread epidemic cases in Braz...

show abstract

Isolation of Novel Beauvericin Analogues from the Fungus Beauveria bassiana

Cited by 94 publications

References 6 publications

<I>Coelomomyces numularius</I> sp. nov. (Blastocladiales: Coelomomycetaceae), a New Fungal Parasite of <I>Anopheles squamosus</I> (Diptera: Culicidae) from Angola, Africa

<I>Coelomomyces numularius</I> sp. nov. (Blastocladiales: Coelomomycetaceae), a New Fungal Parasite of <I>Anopheles squamosus</I> (Diptera: Culicidae) from Angola, Africa

Pharmacological and Therapeutic Potential of Beauvericin: A Short Review

Larvicidal Activity of Beauveria bassiana Extracts against Aedes aegypti and Identification of Beauvericins

Contact Info

Product

Resources

About