Isolation of novel triple‐reassortant swine H3N2 influenza viruses possessing the hemagglutinin and neuraminidase genes of a seasonal influenza virus in Vietnam in 2010

Ngo, Long Thanh; Hiromoto, Yasuaki; Pham, Vu Phong; Le, Ha Thi Hong; Nguyen, Ha; Le, Vu Tri; Takemae, Nobuhiro; Saito, Takehiko

doi:10.1111/j.1750-2659.2011.00267.x

Cited by 47 publications

(58 citation statements)

References 15 publications

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“…Our previous study demonstrated that an IAV-S isolated in southern Vietnam, A/swine/Binh Duong/03-06/2010 (H3N2), was a reassortant between a human H3N2 virus circulating from 2004 to 2006 and a TR IAV-S (29). Specifically, the HA and NA genes of the Vietnamese reassortant originated from the human virus and its internal genes derived from the TR IAV-S, thus suggesting human-to-pig transmission and incursion of North American TR IAV-S into Vietnam.…”

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confidence: 99%

Influenza A Viruses of Swine (IAV-S) in Vietnam from 2010 to 2015: Multiple Introductions of A(H1N1)pdm09 Viruses into the Pig Population and Diversifying Genetic Constellations of Enzootic IAV-S

Takemae

Harada

Nguyen³

et al. 2017

J Virol

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Active surveillance of influenza A viruses of swine (IAV-S) involving 262 farms and 10 slaughterhouses in seven provinces in northern and southern Vietnam from 2010 to 2015 yielded 388 isolates from 32 farms; these viruses were classified into H1N1, H1N2, and H3N2 subtypes. Whole-genome sequencing followed by phylogenetic analysis revealed that the isolates represented 15 genotypes, according to the genetic constellation of the eight segments. All of the H1N1 viruses were entirely A(H1N1) pdm09 viruses, whereas all of the H1N2 and H3N2 viruses were reassortants among 5 distinct ancestral viruses: H1 and H3 triple-reassortant (TR) IAV-S that originated from North American pre-2009 human seasonal H1, human seasonal H3N2, and A(H1N1)pdm09 viruses. Notably, 93% of the reassortant IAV-S retained M genes that were derived from A(H1N1)pdm09, suggesting some advantage in terms of their host adaptation. Bayesian Markov chain Monte Carlo analysis revealed that multiple introductions of A(H1N1)pdm09 and TR IAV-S into the Vietnamese pig population have driven the genetic diversity of currently circulating Vietnamese IAV-S. In addition, our results indicate that a reassortant IAV-S with human-like H3 and N2 genes and an A(H1N1)pdm09 origin M gene likely caused a human case in Ho Chi Minh City in 2010. Our current findings indicate that human-to-pig transmission as well as cocirculation of different IAV-S have contributed to diversifying the gene constellations of IAV-S in Vietnam.

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confidence: 99%

Influenza A Viruses of Swine (IAV-S) in Vietnam from 2010 to 2015: Multiple Introductions of A(H1N1)pdm09 Viruses into the Pig Population and Diversifying Genetic Constellations of Enzootic IAV-S

Takemae

Harada

Nguyen³

et al. 2017

J Virol

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“…Here, we report the characterization of three H3N2 swine influenza viruses, which have surface genes derived from a seasonal H3N2/triple reassortant (TR) swine virus (14) and internal genes from pdm/09-like viruses. Swine/Guangxi/NS2783/2010 (H3N2, GX2783/10) was isolated on 7 November 2010, while Swine/Hong Kong/NS2439/2011 and Swine/Hong Kong/2503/2011 (H3N2, HK2439/11, and HK2503/11, respectively) were isolated on 16 June 2011.…”

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confidence: 99%

“…1). That virus had seasonal human virus-like surface genes and TRlike internal genes and was isolated in Vietnam in February 2010 (14), prior to the first detection of the H3N2 swine influenza virus in China (November 2010).…”

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confidence: 99%

Emergence and Dissemination of a Swine H3N2 Reassortant Influenza Virus with 2009 Pandemic H1N1 Genes in Pigs in China

Fan

Zhu

Zhou

et al. 2012

J Virol

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The 2009 pandemic influenza virus (pdm/09) has been frequently introduced to pigs and has reassorted with other swine viruses. Recently, H3N2 reassortants with pdm/09-like internal genes were isolated in Guangxi and Hong Kong, China. Genetic and epidemiological analyses suggest that these viruses have circulated in swine for some time. This is the first evidence that swine reassortant viruses with pdm/09-like genes may have become established in the field, altering the landscape of human and swine influenza.

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“…Thus, in the USA and Canada, the H1 and recombinant H3N2 viruses are endemic and most contains the TRIG, regardless of subtype. The TRIG is also present in Korea, Vietnam and China (Lorusso et al, 2012;Ngo et al, 2012). Another important event was the emergence, from 2005 in the U.S. (and 2003 in Canada), of the H1N1 and the H1N2 HA gene derived from human IAV (and different from cH1N1).…”

Section: Iav In Swine Worldwidementioning

confidence: 99%

“…In South Korea, besides the cH1N1, TRIG H1N2 and H3N2, the H3N2 of human origin was also introduced (Lee et al, 2008). Likewise, the H3N2 human origin containing the TRIG also circulates in Vietnam (Ngo et al, 2012). In Thailand IAV similar to Eurasian IAV, such as cH1N1, H1N1, H1N1pdm09 and H3N2 (human) are also present.…”

Section: Iav In Swine Worldwidementioning

confidence: 99%

Influenza Virus Infection in Pigs

Zanella¹

2013

VR&R

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Infl uenza A virus is a zoonotic agent of great relevance to human and animal health. Swine is an important host to the dynamics and epidemiology of the infection due to its susceptibility to viruses of both the avian and mammalian virus lineages. Th e great genetic variability of infl uenza viruses is caused by two main genetic mechanisms: point mutations and gene reassortment. Th e latter, by letting the exchange of gene segments between two diff erent infl uenza viruses infecting the same cell, allows a rapid evolution of infl uenza viruses and the emergence of reassortant viruses against which there is no immunity in the host (human or animal). Infl uenza is endemic in pigs in many countries and the emergence of new viruses has been challenging its control and diagnostics. Although infections with infl uenza A virus (IAV) are endemic in most of the pork producing countries throughout the world, in Brazil this pathogen has not received much attention. Since the emergence of the 2009 pandemic H1N1 infl uenza virus in pigs (H1N1pdm09), many outbreaks of respiratory disease were observed in Brazilian swine populations. Currently, in Brazil, H1N1, H3N2 and 2009 pandemic H1N1 (A(H1N1)pdm09) infl uenza A viruses (IAVs) circulate in domestic swine herds.

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Isolation of novel triple‐reassortant swine H3N2 influenza viruses possessing the hemagglutinin and neuraminidase genes of a seasonal influenza virus in Vietnam in 2010

Cited by 47 publications

References 15 publications

Influenza A Viruses of Swine (IAV-S) in Vietnam from 2010 to 2015: Multiple Introductions of A(H1N1)pdm09 Viruses into the Pig Population and Diversifying Genetic Constellations of Enzootic IAV-S

Influenza A Viruses of Swine (IAV-S) in Vietnam from 2010 to 2015: Multiple Introductions of A(H1N1)pdm09 Viruses into the Pig Population and Diversifying Genetic Constellations of Enzootic IAV-S

Emergence and Dissemination of a Swine H3N2 Reassortant Influenza Virus with 2009 Pandemic H1N1 Genes in Pigs in China

Influenza Virus Infection in Pigs

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