Isolation of Peptides with Angiotensin I‐converting Enzyme Inhibitory Effect Derived from Hydrolysate of Upstream Chum Salmon Muscle

Ono, Seigo; Hosokawa, Masashi; Miyashita, Kazuo; Takahashi, Kiyoshi

doi:10.1111/j.1365-2621.2003.tb12300.x

Cited by 76 publications

(53 citation statements)

References 18 publications

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“…Fish and other foods are known to contain anti-hypertensive peptides known as angiotensin I converting enzyme (ACE) inhibitors (Ono, 2003). These bioactive components are found in the muscle flesh of various species (Matsumoto, 1994).…”

Section: Bio-active Peptidesmentioning

confidence: 99%

Marine foods as functional ingredients in bakery and pasta products

Kadam

Prabhasankar

2010

Food Research International

250

135

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Section: Bio-active Peptidesmentioning

confidence: 99%

Marine foods as functional ingredients in bakery and pasta products

Kadam

Prabhasankar

2010

Food Research International

250

135

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“…ACE inhibitory peptides from fish sources were first identified in sardine meat over 20 years ago. Since then ACE inhibitory peptides have been found in various fish species, including sardine, salmon and tuna (Matsufuji et al 1994;Ono et al 2003;Qian et al 2007). The composition and primary sequences of amino acids of marine proteins are different from those of land proteins; therefore, marine proteins may become important protein resources for the selection of novel ACE inhibitory peptides by enzymatic hydrolysis (He et al 2007).…”

Section: Introductionmentioning

confidence: 98%

ACE inhibitory and antioxidant activities of red scorpionfish (Scorpaena notata) protein hydrolysates

2015

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Fish protein hydrolysates with different degrees of hydrolysis were prepared from muscle and heads of red scorpionfish (Scorpaena notata) by treatment with different proteases (Flavourzyme, Trypsin from bovine pancreas and crude enzyme preparations from the intestines of red scorpionfish and from the fungus Penicillium digitatum). The antioxidant and the antihypertensive activities of the hydrolysates were tested. The antioxidant power was evaluated through DPPH free radical scavenging activity, reducing power and metal chelating activity. All hydrolysates showed different degrees of hydrolysis and varying degrees of antioxidant activity. The hydrolysates obtained by treatment with crude enzyme preparations exhibited the highest antioxidant activity. Further, red scorpionfish head protein hydrolysates obtained with fungal protease and with fish crude protease were found to strongly inhibit the angiotensin-I converting enzyme (IC 50 of 0.489 and 0.901 mg/ml, respectively). These results suggested that hydrolysates of red scorpionfish obtained by treatment with crude enzyme preparations would be a beneficial ingredient for functional food or pharmaceuticals against hypertension.

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“…The aim of this current work is to assess whether cryptides, bioactive peptides hidden within the sequence of a parent protein, already identified as potent ACEI, can act on adipogenesis. These cryptides were selected in marine products such as fish, seaweed, and shellfish for their previously documented high inhibitory ACE potency, as demonstrated in administration studies with spontaneously hypertensive rats (SHR) (Ono, Hosokawa, Miyashita, & Takahashi, 2003). They also were chosen for their short-chain nature giving them the opportunity to penetrate in tissue or cells and to resist to endogenous proteases.…”

Section: Introductionmentioning

confidence: 99%

Di and tripeptides from marine sources can target adipogenic process and contribute to decrease adipocyte number and functions

Henda

Laamari

Lanneluc

et al. 2015

Journal of Functional Foods

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International audienceThe effect of 11 marine-derived cryptides was investigated on proliferation, differentiation and maturation of human white pre-adipocytes (HWP). They were all formerly identified as potent Angiotensin-Converting-Enzyme inhibitors.Val-Trp (VW),Val-Tyr (VY), Lys-Tyr (KY), Lys-Trp (KW), Ile-Tyr (IY), Ala-Pro (AP),Val-Ile-Tyr (VIY), Leu-Lys-Pro (LKP), Gly-Pro-Leu (GPL),Ala-Lys-Lys (AKK) and Val-Ala-Pro (VAP) were previously found in fish products and co-products as well as other marine resources like wakame. Treatment with AP, VAP and AKK greatly affected viability of HWP during the proliferation period while KW and VW treatment reduced the number of viable cells during the differentiation stage. A GPL and IY incubation during the differentiation stage allowed the decrease of their final lipid content, of the GPDH activity and of the mRNA level of adipocyte markers (aP2, GLUT4, LPL and AGT). Moreover, a down regulation of both PPARγ and C/EBPα expression, two key regulators of adipogenesis, was observed. These findings indicate that small bioactive peptides from marine protein hydrolysates can target adipogenesis and thus could regulate energy metabolism disorders

show abstract

Isolation of Peptides with Angiotensin I‐converting Enzyme Inhibitory Effect Derived from Hydrolysate of Upstream Chum Salmon Muscle

Cited by 76 publications

References 18 publications

Marine foods as functional ingredients in bakery and pasta products

Marine foods as functional ingredients in bakery and pasta products

ACE inhibitory and antioxidant activities of red scorpionfish (Scorpaena notata) protein hydrolysates

Di and tripeptides from marine sources can target adipogenic process and contribute to decrease adipocyte number and functions

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