Isolation of Protein Tyrosine Phosphatase 1B Inhibitory Constituents from the Sclerotia of Polyporus umbellatus Fries

Lee, Heesang; Hwang, In-Hyun; Kim, Jeong Ah; Choi, Ji-Young; Jang, Tae-Su; Osada, Hiruyuki; Ahn, Joong‐Hoon; Na, MinKyun; Lee, Seungho

doi:10.5012/bkcs.2011.32.2.697

Cited by 6 publications

(3 citation statements)

References 28 publications

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“…The MeOH extract of the sclerotia of the fungus Polyporus umbellatus showed PTP1B inhibitory activity at a level of 30 μg/mL and produced three steroids 271-273 [178] . These steroids showed inhibitory activity with IC 50 values of 8.9±0.3, 6.5±0.6, and 7.5±0.2 μg/mL, respectively.…”

Section: Steroidsmentioning

confidence: 99%

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Natural products possessing protein tyrosine phosphatase 1B (PTP1B) inhibitory activity found in the last decades

2012

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This article provides an overview of approximately 300 secondary metabolites with inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), which were isolated from various natural sources or derived from synthetic process in the last decades. The structure-activity relationship and the selectivity of some compounds against other protein phosphatases were also discussed. Potential pharmaceutical applications of several PTP1B inhibitors were presented.

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Section: Steroidsmentioning

confidence: 99%

“…Ceramide 285, determined to be a C 23 -phytosphingosineing unit containing three hydroxyl groups and C 19 -fatty acid, was isolated from a MeOH extract of the sclerotia of the fungus P umbellatus [178] . This compound showed inhibitory activity with an IC 50 value of 25.1±0.1 μmol/L.…”

Section: N-or S-containing Compoundsmentioning

confidence: 99%

Natural products possessing protein tyrosine phosphatase 1B (PTP1B) inhibitory activity found in the last decades

2012

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“…5,6-Dihydroergosterol or stellasterol ( 8 ) ( Figure 3 ) is widely found as a minor ergostane constituent of many fungi, including sclerotia of Polyporus umbellatus [ 77 ], mycelium of Cordyceps jiangxiensis [ 78 ], Stereum insigne [ 79 ], Eurotium rubrum [ 80 ], fruiting bodies of Stropharia rugosoannulata [ 81 ], Amauroderma amoiensis [ 82 ], Amauroderma subresinosum [ 83 ], Lasiosphaera fenzlii [ 84 ], Cortinarius xiphidipus [ 85 ], Pleurotus eryngii [ 59 ], Trametes versicolor [ 86 ]. For practical purposes, a more suitable source of stellasterol ( 8 ) is its chemical synthesis from ergosterol [ 69 , 87 ].…”

Section: Sterolsmentioning

confidence: 99%

Structure and Biological Activity of Ergostane-Type Steroids from Fungi

2022

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Mushrooms are known not only for their taste but also for beneficial effects on health attributed to plethora of constituents. All mushrooms belong to the kingdom of fungi, which also includes yeasts and molds. Each year, hundreds of new metabolites of the main fungal sterol, ergosterol, are isolated from fungal sources. As a rule, further testing is carried out for their biological effects, and many of the isolated compounds exhibit one or another activity. This study aims to review recent literature (mainly over the past 10 years, selected older works are discussed for consistency purposes) on the structures and bioactivities of fungal metabolites of ergosterol. The review is not exhaustive in its coverage of structures found in fungi. Rather, it focuses solely on discussing compounds that have shown some biological activity with potential pharmacological utility.

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ChemInform Abstract: Isolation of Protein Tyrosine Phosphatase 1B Inhibitory Constituents from the Sclerotia of Polyporus umbellatus Fries.

et al. 2011

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The new phytosphingosine-type ceramide (I) containing a 2-hydroxy fatty acid, and six known steroids are isolated from the title plant. All compounds are tested for their inhibitory activity against PTP1B. Ceramide (I) shows marginal activity. -(LEE, H. S.; HWANG, I. H.; KIM, J. A.; CHOI, J. Y.; JANG, T.-S.; OSADA, H.; AHN*, J. S.; NA, M.; LEE, S. H.; Bull. Korean Chem. Soc. 32 (2011) 2, 697-700, http://dx.doi.org/10.5012/bkcs.

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Isolation of Protein Tyrosine Phosphatase 1B Inhibitory Constituents from the Sclerotia of Polyporus umbellatus Fries

Cited by 6 publications

References 28 publications

Natural products possessing protein tyrosine phosphatase 1B (PTP1B) inhibitory activity found in the last decades

Natural products possessing protein tyrosine phosphatase 1B (PTP1B) inhibitory activity found in the last decades

Structure and Biological Activity of Ergostane-Type Steroids from Fungi

ChemInform Abstract: Isolation of Protein Tyrosine Phosphatase 1B Inhibitory Constituents from the Sclerotia of Polyporus umbellatus Fries.

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