1980
DOI: 10.1002/jmv.1890050306
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Isolation of rhinoviruses and coronaviruses from 38 colds in adults

Abstract: Nasal washings were collected from 27 normal adults during 38 naturally acquired colds. The washings were exhaustively tested using tissue cultures, organ cultures and electron microscopy. Washings yielding no identifiable agent were inoculated into human volunteers, and further specimens obtained from the latter were examined by the same techniques in vitro. Viruses were identified in association with 25 of the original 38 colds (65.7%). Fifteen were rhinoviruses (39.5%), seven coronaviruses (18.4%), two were… Show more

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Cited by 163 publications
(106 citation statements)
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“…The proportion attributed to rhinovirus in other age groups was adjusted upward by the same factor. A similar process was followed for coronaviruses, setting the proportion of coronavirus-associated illnesses in young adults at 18 %, that reported by Larson and colleagues [25]. It was assumed that coronavirus distribution in other age groups would follow that of rhinoviruses.…”
Section: Isolation Of Virusesmentioning
confidence: 88%
See 1 more Smart Citation
“…The proportion attributed to rhinovirus in other age groups was adjusted upward by the same factor. A similar process was followed for coronaviruses, setting the proportion of coronavirus-associated illnesses in young adults at 18 %, that reported by Larson and colleagues [25]. It was assumed that coronavirus distribution in other age groups would follow that of rhinoviruses.…”
Section: Isolation Of Virusesmentioning
confidence: 88%
“…Estimates of the proportion of illnesses caused by such fastidious rhinoviruses can be derived from a study by Larson. Reed and Tyrrell [25]. They conducted an exhaustive study of 38 respiratory infections in adults using not only all cell culture and human tracheal organ culture, but also inoculation of human volunteers.…”
Section: Isolation Of Virusesmentioning
confidence: 99%
“…1} There are more than 100 known serotypes of human rhinovirus,2) and they are thought to be responsible for 40~60% of the common colds. 3) In principle, compoundswhich inhibit the proteolytic action of the 3C protease would disrupt replication of the rhinovirus, and could lead to an effective drug treatment for the common cold.…”
mentioning
confidence: 99%
“…In our study HI-antibody titres to human coronavirusOC43 in the student nurses were consistently higher than in the medical students, a finding which cannot be explained by the few detected titre rises (student nurses 8; medical technology students 4). It may well be that we also measured cross-reacting antibodies due to infection with related strains (McIntosh et al 1974;Larson, Reed & Tyrrell, 1980) and that the short-lived and low antibody response due to cross-reactive antibodies did not show up as fourfold titre increases in our test system. It has been speculated (Reed, 1984) that antigenic variants within the two main groups of human coronavirus (Macnaughton, Madge & Reed, 1981) are at least partially responsible for the reinfections observed in adults.…”
Section: Discussionmentioning
confidence: 95%