Isolation of Salicylsalicylic Acid, Acetylsalicylsalicylic Acid, and Acetylsalicylic Anhydride from Aspirin Tablets by Extraction and High‐Pressure Liquid Chromatography

Absorptiometric Determination of Acetylsalicylic Acid in Aqueous Ethanolic Solution

“…Several methods have been developed for the determination of this compound and its degradation by-product in vitro and in vivo. These methods include chromatography (Pereira et al 1998;Verstraeten, Roets, and Hoogmartens 1987;Bevitt, Mather, and Sharman 1984;Fogel, Epstein, and Chen 1984;Reepmer and Kichhoefer 1979;Ali 1976), fluorometry (Karim et al 2006;Miles and Schenk 1970;Lange and Bell 1966), colorimetry (Farid et al 1975;Trinder 1954), absorptiometry (Quinn 1994;Kitamura, Takagi, and Hozumi 1984;Kitamura and Majuna 1983;Fernandez and Klappmeier 1978), and voltammetry and potentiometry (Fernandez et al 1998;Fung and Luk 1989;Hassan and Hamada 1988). However, these methods require prior treatment and time-consuming steps (Pereira, Aniceto, and Fatibello-Filho 1998;Verma and Jain 1986;Juhl and Kichhhofer 1980;Routh et al 1967;Levine 1961;Brodie, Udenfriend, and Coburn 1944) and often involve an indirect determination through the determination of salicylic acid (SA).…”

Aspirin—A national survey III: Determination of impurities in bulk aspirin and aspirin formulations by high-pressure liquid chromatography and spectrophotometry

“…Compound 111 has been identified in these laboratories by IR, UV, and mass spectrometry and TLC after isolation (14). Therefore, I could not be determined by HPLC.…”

Determination of Related Compounds in Aspirin by Liquid Chromatography

“…Keyphrases Aspirin-determination of salicylic acid and related compounds by liquid chromatography Liquid chromatographydetermination of salicylic acid and related compounds in aspirin 0 Salicylic acid-determination in aspirin by liquid chromatography, related compounds Several recent papers (1)(2)(3)(4)(5) have discussed the possible immunological response to the presence of low levels of related compounds in aspirin. Methods, too numerous to discuss, employing gas chromatography, spectrophotometry, liquid chromatography, etc., have been published describing the determination of salicylic acid (I), salsalate (11), acetylsalicylic anhydride (III), and acetylsalicylsalicylic acid (IV) in aspirin.…”

“…Reversed-phase methods are not desirable because I11 and aspirin are not stable in the mixed aqueous-organic eluents used in that form of LC (5). Reversed-phase methods are not desirable because I11 and aspirin are not stable in the mixed aqueous-organic eluents used in that form of LC (5).…”