Isolation of Salmonella Enterica Serotype Isangi From a Suspected Case of Enteric Encephalopathy

The rare Salmonella enterica serovar Isangi: genomic characterization of the antimicrobial resistance, virulence potential and epidemiology of Brazilian strains in comparison to global isolates

“…S. Isangi is an NTS serovar, detected in various countries at low frequencies, associated with invasive nosocomial infections in humans and increasing antimicrobial resistance rates [10,[12][13][14][15][16][17][18][19][20][21][22][23]. Few studies have been conducted exclusively with strains of this serovar, probably due to its rare occurrence in many countries, so there is little information available regarding specific traits of this serotype and its genetic relatedness in a global context.…”

“…Studies conducted in other countries that analysed S . Isangi have demonstrated extensive resistance to beta-lactam drugs in those isolates, including the detection of novel variants of beta-lactamase-encoding genes such as bla TEM and bla CTX-M [12–15, 18, 20, 21]. This was observed among the additional global isolates, where several genes encoding beta-lactam resistance ( bla OXA-48 , bla CTX-M-15 , bla CTX-M-2 , bla DHA-1 , bla LAP-2 , bla NDM-1 , bla OXA-1 , bla OXA-10 , bla SCO-1 , bla TEM-1 , bla TEM-1B , bla TEM-63 ) were found in diverse frequencies in genomes from the USA, UK, Nigeria, Ireland and, mainly, South Africa (Table S2).…”

“…This serovar was first described in a salmonellosis case by Jurukov and colleagues in 1967 [11]. Since then, S. Isangi has been detected among adult and paediatric humans usually related to invasive and nosocomial infections associated with increasing antimicrobial resistance rates [12][13][14][15][16][17][18][19][20]. Geographically, S. Isangi strains have been reported in the USA, UK, and Asian, European and, most frequently, African countries [10,[12][13][14][15][16][17][18][19][20][21][22][23].…”

“…Since then, S. Isangi has been detected among adult and paediatric humans usually related to invasive and nosocomial infections associated with increasing antimicrobial resistance rates [12][13][14][15][16][17][18][19][20]. Geographically, S. Isangi strains have been reported in the USA, UK, and Asian, European and, most frequently, African countries [10,[12][13][14][15][16][17][18][19][20][21][22][23]. In Brazil, previous studies detected S. Isangi isolates in food items, food-producing animals and the environment [10,22], which could be of particular concern considering that Brazil is currently ranked high among the main meat-exporting countries of the world [24].…”

“…Since then, S . Isangi has been detected among adult and paediatric humans usually related to invasive and nosocomial infections associated with increasing antimicrobial resistance rates [12–20]. Geographically, S .…”