Isolation of Stilbenoids and Lignans from &lt;i&gt;Dendrobium hongdie&lt;/i&gt;

Yg, Chen; Yu, Hong; Lian, Xiao-Yuan

doi:10.4314/tjpr.v14i11.15

Cited by 17 publications

(7 citation statements)

References 15 publications

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“…The eleven known compounds were identified as densiflorol B ( 3 ) [14], 6,7-dimethoxy-phenanthrene-2,5-diol ( 4 ) [27], dehydroorchinol ( 5 ) [8], 1,5,7-trimethoxy-2-phenanthrenol ( 6 ) [8], denthyrsinin ( 7 ) [28], ephemeranthol A ( 8 ) [29], lusianthridin ( 9 ) [30], moscatilin ( 10 ) [18], gigantol ( 11 ) [12], 3-[( 1E )-2-(3-Hydroxyphenyl)ethenyl]-5-methoxyphenol ( 12 ) [31], and (−)-syringaresinol ( 13 ) [19] by comparing their spectroscopic data with the published data (Supplementary Materials Figures S11–S32). Although the known compounds ( 3 – 11 and 13 ) have been isolated from Dendrobium species, the isolation of compound 12 from Dendrobium species has not been reported yet.…”

Section: Resultsmentioning

confidence: 99%

“…Phenanthrenes have been reported to have anti-inflammatory [6,7,8], antifibrotic [9], anti-cancer [10,11,12], and antibacterial activities [13]. Bibenzyl compounds, including stilbenes, are also abundant in Dendrobium species [14,15,16,17,18,19] with diverse activities, such as antioxidant [14], anti-inflammatory [14], anti-migratory [15], retinal neoangiogenesis inhibitory [16], and antimutagenic [17,18] activities.…”

Section: Introductionmentioning

confidence: 99%

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Identification of Two New Phenanthrenes from Dendrobii Herba and Their Cytotoxicity towards Human Hypopharynx Squamous Carcinoma Cell (FaDu)

et al. 2019

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Two new phenanthrenes, (1R,2R)-1,7-hydroxy-2,8-methoxy-2,3-dihydrophenanthrene-4(1H)-one (1) and 2,7-dihydroxy-phenanthrene-1,4-dione (2), were isolated from the ethyl acetate-soluble fraction of Dendrobii Herba, together with seven known phenanthrenes (3–9), two bibenzyls (10–12), and a lignan (13). Structures of 1 and 2 were elucidated by analyzing one-dimensional (1D) and two-dimensional (2D)-NMR and High-resolution electrospray ionization mass spectra (HR-ESI-MS) data. The absolute configuration of compound 1 was confirmed by the circular dichroism (CD) spectroscopic method. In cytotoxicity assay using FaDu human hypopharynx squamous carcinoma cell line, compounds 3–6, 8, 10, and 12 showed activities, with IC50 values that ranged from 2.55 to 17.70 μM.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Identification of Two New Phenanthrenes from Dendrobii Herba and Their Cytotoxicity towards Human Hypopharynx Squamous Carcinoma Cell (FaDu)

et al. 2019

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“…Compound 6 , syringaresinol, was isolated from Tripterygium wilfordii , and it was structurally elucidated for the first time in 1976 [ 48 ]. Syringaresinol is a member of lignans, which has been increasingly reported to be found in several Dendrobium species [ 35 , 49 , 50 , 51 ]. This lignan has been proven recently to have no function to promote glucose uptake in 3T3L-1 cells [ 52 ].…”

Section: Discussionmentioning

confidence: 99%

Secondary Metabolites in the Dendrobium heterocarpum Methanolic Extract and Their Impacts on Viability and Lipid Storage of 3T3-L1 Pre-Adipocytes

et al. 2022

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Although many natural products have proven their potential to regulate obesity through the modulation of adipocyte biology, none of them has yet been approved for clinical use in obesity therapy. This work aims to isolate valuable secondary metabolites from an orchid species (Dendrobium heterocarpum) and evaluate their possible roles in the growth and differentiation of 3T3-L1 pre-adipocytes. Six compounds were isolated from the orchid’s methanolic extracts and identified as amoenylin (1), methyl 3-(4-hydroxyphenyl) propionate (2), 3,4-dihydroxy-5,4’-dimethoxybibenzyl (3), dendrocandin B (4), dendrofalconerol A (5), and syringaresinol (6). Among these phytochemicals, compounds 2, 3, and 6 exhibited lower effects on the viability of 3T3-L1 cells, offering non-cytotoxic concentrations of ≲10 µM. Compared to others tested, compound 3 was responsible for the maximum reduction of lipid storage in 3T3-L1 adipocytes (IC50 = 6.30 ± 0.10 µM). A set of protein expression studies unveiled that compound 3 at non-cytotoxic doses could suppress the expression of some key transcription factors in adipocyte differentiation (i.e., PPARγ and C/EBPα). Furthermore, this compound could deactivate some proteins involved in the MAPK pathways (i.e., JNK, ERK, and p38). Our findings prove that D. heterocarpum is a promising source to explore bioactive molecules capable of modulating adipocytic growth and development, which can potentially be assessed and innovated further as pharmaceutical products to defeat obesity.

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“…The known phenolic derivatives was identified as 2', 3-dihydroxy-4, 5-dimethoxybibenzyl (3) [13], 2', 3-dihydroxy-5-methoxybibenzyl (4) [14], batatasin Ⅲ (5) [15], tristin (6) [13], 3-hydroxy-1, 7-bis-(4', 4''-dihydroxyphenyl)-heptane (7) [11], platyphyllenone (8) [16] by analysis of its spectroscopic and MS data with those reported in this literature.…”

Section: Spectroscopic Datamentioning

confidence: 99%