Isolation of Talathermophilins from the Thermophilic Fungus Talaromyces thermophilus YM3-4

Guo, Jipeng; Tan, Jun; Wang, Yanli; Wu, Hong-Yang; Chuan-ping, Zhang; Niu, Xue‐Mei; Pan, Wen-Zheng; Huang, Xiaowei; Zhang, Ke‐Qin

doi:10.1021/np200365z

Cited by 45 publications

(44 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Unlike notoamide B, metabolites tentatively identified by HPLC-MS as dihydrotalathermophilins A and B appear to be efficiently converted into the talathermophilins A and B, which, according to metabolite profiling, appear to be the end-products. Indeed these dihydrotalathermophilins A and B were recently structure elucidated 58b and named talathermophilin C and D. There were no indications of other metabolites with a bicyclo[2.2.2]diazaoctane ring system and/or any of the spiro -compunds of the notoamide type in Talaromyces thermophilus , where glycine or alanine analogues of the proline-derived metabolites discussed here could theoretically have been secondary metabolites in this themophilic species.…”

Section: Related Metabolites Lacking the Bicyclo[222]diazaoctane Rimentioning

confidence: 72%

“…57 P. westlingii was treated as a synonym of P. waksmanii by Pitt, 37 but has later been shown to be a valid species. 35a,57 Talaromyces thermophilus strain YM 1-3 produces talathermophilins A and B, 58 secondary metabolites related to notoamide E, except that glycine or alanine is replacing proline and the end-products have a double-bond conjugating one of the ketones in the dioxopiperazine to the indole part of the molecule. We have found that the glycine and alanine notoamide E analogues (without the extended conjugation) are also formed in Talaromyces thermophilus CBS 116.72, albeit accumulated in much smaller amounts compared to the end-products.…”

Section: Related Metabolites Lacking the Bicyclo[222]diazaoctane Rimentioning

confidence: 99%

“…58a These new metabolites have been postulated to serve as potential precursors to the more advanced metabolites containing the bridging bicycle. Unlike notoamide B, metabolites tentatively identified by HPLC-MS as dihydrotalathermophilins A and B appear to be efficiently converted into the talathermophilins A and B, which, according to metabolite profiling, appear to be the end-products.…”

Section: Related Metabolites Lacking the Bicyclo[222]diazaoctane Rimentioning

confidence: 99%

See 2 more Smart Citations

Fungal Origins of the Bicyclo[2.2.2]diazaoctane Ring System of Prenylated Indole Alkaloids

et al. 2012

View full text Add to dashboard Cite

Over eight different families of natural products consisting of nearly 70 secondary metabolites that contain the bicyclo[2.2.2]diazaoctane ring system have been isolated from various Aspergillus, Penicillium, and Malbranchea species. Since 1968, these secondary metabolites have been the focus of numerous biogenetic, synthetic, taxonomic, and biological studies and, as such, have made a lasting impact across multiple scientific disciplines. This review covers the isolation, biosynthesis, and biological activity of these unique secondary metabolites containing the bridging bicyclo[2.2.2]diazaoctane ring system. Furthermore, the diverse fungal origin of these natural products is closely examined and, in many cases, updated to reflect the currently accepted fungal taxonomy.

show abstract

Section: Related Metabolites Lacking the Bicyclo[222]diazaoctane Rimentioning

confidence: 72%

Section: Related Metabolites Lacking the Bicyclo[222]diazaoctane Rimentioning

confidence: 99%

Section: Related Metabolites Lacking the Bicyclo[222]diazaoctane Rimentioning

confidence: 99%

See 1 more Smart Citation

Fungal Origins of the Bicyclo[2.2.2]diazaoctane Ring System of Prenylated Indole Alkaloids

et al. 2012

View full text Add to dashboard Cite

show abstract

“…Thermophilic fungi received little attention though strains keyed out as Aspergillus clavatus (Jiang et al ) and Talaromyces thermophilus (Chu et al ; Guo et al ) have been reported.…”

Section: High‐temperature Environmentsmentioning

confidence: 99%

“…com.). Aspergillus clavatus(Jiang et al 2013) and Talaromyces thermophilus(Chu et al 2010;Guo et al 2011) have been reported.…”

mentioning

confidence: 99%

Extreme environments: microbiology leading to specialized metabolites

et al. 2019

View full text Add to dashboard Cite

Summary The prevalence of multidrug‐resistant microbial pathogens due to the continued misuse and overuse of antibiotics in agriculture and medicine is raising the prospect of a return to the preantibiotic days of medicine at the time of diminishing numbers of drug leads. The good news is that an increased understanding of the nature and extent of microbial diversity in natural habitats coupled with the application of new technologies in microbiology and chemistry is opening up new strategies in the search for new specialized products with therapeutic properties. This review explores the premise that harsh environmental conditions in extreme biomes, notably in deserts, permafrost soils and deep‐sea sediments select for micro‐organisms, especially actinobacteria, cyanobacteria and fungi, with the potential to synthesize new druggable molecules. There is evidence over the past decade that micro‐organisms adapted to life in extreme habitats are a rich source of new specialized metabolites. Extreme habitats by their very nature tend to be fragile hence there is a need to conserve those known to be hot‐spots of novel gifted micro‐organisms needed to drive drug discovery campaigns and innovative biotechnology. This review also provides an overview of microbial‐derived molecules and their biological activities focusing on the period from 2010 until 2018, over this time 186 novel structures were isolated from 129 representatives of microbial taxa recovered from extreme habitats.

show abstract

Cladosporioles A and B, Two New Indole Derivatives from the Deep‐Sea‐Derived Fungus Cladosporium cladosporioides 170056

Zou

Chen

et al. 2022

Chemistry & Biodiversity

View full text Add to dashboard Cite

Two new (cladosporioles A and B, 1 and 2) and fourteen known (3–16) compounds were isolated from the deep‐sea‐derived fungus Cladosporium cladosporioides 170056. The relative structures of the new compounds were elucidated mainly by detailed analysis of their NMR and HR‐ESI‐MS spectroscopic data. Their absolute configurations were determined by comparison of the experimental and calculated electronic circular dichroism (ECD) spectra. All isolates were tested for antimicrobial activity against Vibrio parahaemolyticus. Compound 15 exhibited weak effect with the MIC value of 156.25 μg/mL.

show abstract

Isolation of Talathermophilins from the Thermophilic Fungus Talaromyces thermophilus YM3-4

Cited by 45 publications

References 26 publications

Fungal Origins of the Bicyclo[2.2.2]diazaoctane Ring System of Prenylated Indole Alkaloids

Fungal Origins of the Bicyclo[2.2.2]diazaoctane Ring System of Prenylated Indole Alkaloids

Extreme environments: microbiology leading to specialized metabolites

Cladosporioles A and B, Two New Indole Derivatives from the Deep‐Sea‐Derived Fungus Cladosporium cladosporioides 170056

Contact Info

Product

Resources

About