Isolation of the Human Semaphorin III/F Gene (SEMA3F) at Chromosome 3p21, a Region Deleted in Lung Cancer

Xiang, Ruihua; Hensel, Charles H.; Garcia, Dawn; Carlson, Helene C.; Kok, Klaas; Daly, Maria C.; Kerbacher, Karen; Berg, Anke van den; Veldhuis, P.; Buys, Charles H.C.M.; Naylor, Susan L.

doi:10.1006/geno.1996.0074

Cited by 135 publications

(87 citation statements)

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“…We then determined whether the expression of integrin avb3, which has been shown as a key mediator of cellmatrix attachment and motility (12)(13)(14) was regulated in the cancer cells by SEMA3 alteration. We found that SEMA3B and SEMA3F restoration by ectopic expression resulted in the reduction of integrin avb3 (Fig.…”

Section: Ectopic Expression Of Sema3b and Sema3f Inhibit In Vitro Tummentioning

confidence: 99%

“…Class 3 SEMAs (SEMA3) serve as key regulators of cellular processes, such as cell survival, proliferation, apoptosis, and migration (11,12). Both SEMA3F and SEMA3B are mapped to chromosome 3p21.3, a region of frequent loss in lung, breast, and endometrial cancers (13)(14)(15). Most SEMAs directly bind to plexins which elicit intracellular signals (16).…”

Section: Introductionmentioning

confidence: 99%

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Progesterone and 1,25-Dihydroxyvitamin D3 Inhibit Endometrial Cancer Cell Growth by Upregulating Semaphorin 3B and Semaphorin 3F

Nguyen

Ivanova

Kavandi

et al. 2011

Molecular Cancer Research

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Class 3 semaphorins (SEMA), SEMA3B and SEMA3F, are secreted proteins that regulate angiogenesis, tumor growth, and metastasis by binding to their transmembrane receptor complex consisting of plexins and neuropilins (NP). Expression of SEMAs and their receptors was assessed in tissue microarrays by immunohistochemistry. SEMA3B, SEMA3F, and plexin A3 were expressed strongly in normal endometrial tissues, whereas grade-dependent decreases were found in endometrial carcinomas.

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Section: Ectopic Expression Of Sema3b and Sema3f Inhibit In Vitro Tummentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Progesterone and 1,25-Dihydroxyvitamin D3 Inhibit Endometrial Cancer Cell Growth by Upregulating Semaphorin 3B and Semaphorin 3F

Nguyen

Ivanova

Kavandi

et al. 2011

Molecular Cancer Research

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“…The SEMA3B protein is an extracellular secreted protein. The second semaphorin gene (SEMA3F/SEMA IIIF/SEMA-IV) in the region was identified experimentally and cloned independently by several groups (Roche et al, 1996;Sekido et al, 1996;Xiang et al, 1996). The gene space of *28 kb (NM_004186) encodes a 3 and/or 4 kb mRNA (753 aa and 786 aa) composed of 18 exons.…”

Section: Sema3b and Sema3fmentioning

confidence: 99%

Tumor suppressor genes on chromosome 3p involved in the pathogenesis of lung and other cancers

Zabarovsky¹,

2002

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Loss of heterozygosity (LOH) involving several chromosome 3p regions accompanied by chromosome 3p deletions are detected in almost 100% of small (SCLCs) and more than 90% of non-small (NSCLCs) cell lung cancers. In addition, these changes appear early in the pathogenesis of lung cancer and are found as clonal lesions in the smoking damaged respiratory epithelium including histologically normal epithelium as well as in epithelium showing histologic changes of preneoplasia. These 3p genetic alterations lead to the conclusion that the short arm of human chromosome 3 contains several tumor suppressor gene(s) (TSG(s)). Although the first data suggesting that 3p alterations were involved in lung carcinogenesis were published more than 10 years ago, only recently has significant progress been achieved in identifying the candidate TSGs and beginning to demonstrate their functional role in tumor pathogenesis. Some of the striking results of these findings has been the discovery of multiple 3p TSGs and the importance of tumor acquired promoter DNA methylation as an epigenetic mechanism for inactivating the expression of these genes in lung cancer. This progress, combined with the well known role of smoking as an environmental causative risk factor in lung cancer pathogenesis, is leading to the development of new diagnostic and therapeutic strategies which can be translated into the clinic to combat and prevent the lung cancer epidemic. It is clear now that genetic and epigenetic abnormalities of several genes residing in chromosome region 3p are important for the development of lung cancers but it is still obscure how many of them exist and which of the numerous candidate TSGs are the key players in lung cancer pathogenesis. We review herein our current knowledge and describe the most credible candidate genes.

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“…One region has three SCLC homozygous deleted cell lines, NCI-H740, NCI-H1450, and GLC20 and one breast cancer cell line, HCC1500, indicating the minimum common deleted region to 7120 kb (Sekido et al, 1998a). Several candidate genes including SEMA3B, SEMA3F, CAC-NA2D2 have been identi®ed at the deletion region (Gao et al, 2000;Roche et al, 1996;Sekido et al, 1996;Xiang et al, 1996), and the RASSF1 gene has been proposed to be a targetted TSG owing to its frequent inactivation by hypermethylation in many lung cancers (Dammann et al, 2000). The other two regions around the 3p21.3 are the 3p21.3-22 region including ®ve SCLC cell lines including ACC-LC-5 (Yamakawa et al, 1993) and the another 3p21.3 region harboring the BAP1 gene region that has been deleteted in one NSCLC cell line, NCI-H226 (Jensen et al, 1998).…”

Section: (C) Pcr Analysis Of Genomic Dnas Using a Primer Set To Crossmentioning

confidence: 99%

Genetic alteration of the β-catenin gene (CTNNB1) in human lung cancer and malignant mesothelioma and identification of a new 3p21.3 homozygous deletion

et al. 2001

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Isolation of the Human Semaphorin III/F Gene (SEMA3F) at Chromosome 3p21, a Region Deleted in Lung Cancer

Cited by 135 publications

References 0 publications

Progesterone and 1,25-Dihydroxyvitamin D3 Inhibit Endometrial Cancer Cell Growth by Upregulating Semaphorin 3B and Semaphorin 3F

Progesterone and 1,25-Dihydroxyvitamin D3 Inhibit Endometrial Cancer Cell Growth by Upregulating Semaphorin 3B and Semaphorin 3F

Tumor suppressor genes on chromosome 3p involved in the pathogenesis of lung and other cancers

Genetic alteration of the β-catenin gene (CTNNB1) in human lung cancer and malignant mesothelioma and identification of a new 3p21.3 homozygous deletion

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