1986
DOI: 10.1111/j.1744-313x.1986.tb01090.x
|View full text |Cite
|
Sign up to set email alerts
|

Isolation of the MHC Genes Encoding the Tumour‐specific Class I Antigens Expressed on a Murine Fibrosarcoma

Abstract: SUMMARY The C3H UV‐induced fibrosarcoma, 1591, is highly immunogenic and, therefore, is readily rejected when transplanted into immunocompetent syngeneic recipients. Previous analysis of 1591 with tumour‐specific or H‐2‐reactive monoclonal antibodies revealed that this antigenicity might be due to the expression of two novel class I major histocompatibility complex (MHC) antigens. In this report we describe the molecular cloning and initial characterization of three genes which account for all of the unique se… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1

Citation Types

3
38
0

Year Published

1987
1987
2010
2010

Publication Types

Select...
6
3

Relationship

0
9

Authors

Journals

citations
Cited by 30 publications
(41 citation statements)
references
References 30 publications
3
38
0
Order By: Relevance
“…1591 is a UV-induced C3H fibrosarcoma that expresses several class I epitopes not normally found on C3H tissue, in addition to normal H-2k products (15). Previously, we cloned three class I genes from the 1591 genome whose products account for the expression of these apparently allogeneic epitopes and examined the recognition of these products by several CTL clones and viral-specific and alloreactive CTL cultures (12,16). One of these genes, H-2L'49 [previously referred to as A149 (12) H-2L 149 u-.n k highly homologous to the H-2Ld gene derived from BALB/c and encodes a distinct product that is recognized by a subset of H-2Ld-reactive CTL clones.…”
Section: Resultsmentioning
confidence: 99%
“…1591 is a UV-induced C3H fibrosarcoma that expresses several class I epitopes not normally found on C3H tissue, in addition to normal H-2k products (15). Previously, we cloned three class I genes from the 1591 genome whose products account for the expression of these apparently allogeneic epitopes and examined the recognition of these products by several CTL clones and viral-specific and alloreactive CTL cultures (12,16). One of these genes, H-2L'49 [previously referred to as A149 (12) H-2L 149 u-.n k highly homologous to the H-2Ld gene derived from BALB/c and encodes a distinct product that is recognized by a subset of H-2Ld-reactive CTL clones.…”
Section: Resultsmentioning
confidence: 99%
“…Two of these genes are highly homologous to the L d gene from BALB/c mice, and a third is quite homologous to the Kk gene throughout its 3' region (99). Furthermore, analysis of fi broblastic lines transfected with each of the three novel class I genes indicates that these sequences encode products recognized by the same monoclonal antibodies and CTL clones that are reactive with the original 1591 tumor (98,99).…”
Section: Qualitative Changes Of Class I Antigens On Tumor Cellsmentioning
confidence: 99%
“…Goodenow and coworkers have subsequently cloned the genes that encode these novel antigens and have demonstrated that the 1591 tumor expresses, in addition to a normal complement of class I antigens, at least three novel class I molecules not normally expressed in C3H mice (98). Two of these genes are highly homologous to the L d gene from BALB/c mice, and a third is quite homologous to the Kk gene throughout its 3' region (99).…”
Section: Qualitative Changes Of Class I Antigens On Tumor Cellsmentioning
confidence: 99%
“…To determine whether TGF-,B secreted in the latent form can be immunoregulatory, a TGF-,81 cDNA driven by the simian virus 40 early promoter was transfected into a highly immunogenic, C3H-derived, UV-induced fibrosarcoma, designated 1591. The 1591 tumor is highly immunogenic and expresses three major histocompatibility complex class I antigens not found in the genome of the k haplotype (6)(7)(8). The tumors elicit a primary cytolytic T-lymphocyte (CTL) response in vitro, and tumor rejection requires CD8+ T cells, which recognize the K216 gene product (9).…”
mentioning
confidence: 99%