Isolation of the Ovine Agouti Coding Sequence

Parsons, Y. M.; Fleet, M. R.; Cooper, D. W.

doi:10.1111/j.1600-0749.1999.tb00524.x

Cited by 18 publications

(13 citation statements)

References 18 publications

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“…The Agouti locus codes a protein that binds to the melanocortin receptor (MC1R). In its absence, melanocyte stimulating hormone (αMSH) binds to MC1R and signals the production of eumelanin (black to brown pigment), which causes colour expression in fleece and hair [25]. Recently, Smit et al [31] suggested that two agouti loci exist, and our evidence supports this hypothesis.…”

Section: Pigmentation Genessupporting

confidence: 80%

Major genes and QTL influencing wool production and quality: a review

Purvis

Franklin

2005

Genet. Sel. Evol.

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-The opportunity exists to utilise our knowledge of major genes that influence the economically important traits in wool sheep. Genes with Mendelian inheritance have been identified for many important traits in wool sheep. Of particular importance are genes influencing pigmentation, wool quality and the keratin proteins, the latter of which are important for the morphology of the wool fibre. Gene mapping studies have identified some chromosomal regions associated with variation in wool quality and production traits. The challenge now is to build on this knowledge base in a cost-effective way to deliver molecular tools that facilitate enhanced genetic improvement programs for wool sheep.gene / major gene / QTL / wool production / wool quality

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Section: Pigmentation Genessupporting

confidence: 80%

Major genes and QTL influencing wool production and quality: a review

Purvis

Franklin

2005

Genet. Sel. Evol.

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“…1; Parsons et al 1999b). A previously reported 5-bp deletion, g.100-105delAGGAA (denoted D 5 ), was present in exon 2 (Smit et al 2002).…”

Section: Mutation Screeningmentioning

confidence: 88%

A gene duplication affecting expression of the ovine ASIP gene is responsible for white and black sheep

Norris¹,

Whan²

2008

Genome Res.

258

244

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Agouti signaling protein (ASIP) functions to regulate pigmentation in mice, while its role in many other animals and in humans has not been fully determined. In this study, we identify a 190-kb tandem duplication encompassing the ovine ASIP and AHCY coding regions and the ITCH promoter region as the genetic cause of white coat color of dominant white/tan (A Wt ) agouti sheep. The duplication 5Ј breakpoint is located upstream of the ASIP coding sequence. Ubiquitous expression of a second copy of the ASIP coding sequence regulated by a duplicated copy of the nearby ITCH promoter causes the white sheep phenotype. A single copy ASIP gene with a silenced ASIP promoter occurs in recessive black sheep. In contrast, a single copy functional wild-type (A +

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“…In sheep, the candidate genes for recessive black (ASIP) (Parsons et al, 1999a(Parsons et al, , 1999b, dominant black (MC1R) (Vage et al, 1999(Vage et al, , 2003 and Brown (TYRP1) (Beraldi et al, 2006) have been found; these genes are known to influence pigmentation or pigment synthesis level. Many white spotting traits have been identified in mouse and man; and 10 of the responsible genes have been cloned (Baxter et al, 2004).…”

Section: Introductionmentioning

confidence: 97%