According to the World Health Organization, 80% of the world population uses medicinal plants in the treatment of diseases and in African countries, this figure is much higher. 4 Equally, medicinal plants are rich sources of substances that are claimed to induce paraimmunity 5 and relieve oxidative stress. 6 Immunomodulators of plant origin are preferred because they are mostly presumed to be less toxic and therefore safer. 7 Phytochemical constituents such as terpenoids, steroids, proteins, tannins, alkaloids and flavonoids are considered responsible for immunomodulatory properties exhibited by plants, which remain alternative sources for the development of new drugs. 8,9 G.africanum popularly known as 'afang'(Efik), 'okazi'(Igbo) is one of the most popular leafy vegetables in Nigeria and other African countries such as Cameroon, Gabon, Congo, and Angola. 10 G.africanum, a lone genus belonging to the family Gnataceae is a dioecious wild understory liana that grows on trees in the humid forest of Africa. 10 Its leaves are eaten as a vegetable, either raw or finely chopped and cooked. They are also widely used as an ingredient in soups and stews and are much in demand for their nutritional and therapeutic properties. 11 The leaves of G.africanum are traditionally used in the treatment of enlarged spleen, sore throat, and as cathartic in Nigeria. 12 Pharmacological studies on the plant have shown that it has anti-inflammatory 13 , antimicrobial and antifungal, 14,15,16 antioxidant, 17,18 haematological 19 and anti-sickling properties. 20 Many therapeutic effects of plant extracts have been suggested to be due to their wide array of immunomodulatory effects and influence on the immune system of the human body.