Isolation of Triterpenoid Glycosides (Saikosaponins) from<i>Bupleurum kunmingense</i>and Their Chemical Stmctures

Seto, Haruo; Ōtake, Noboru; Luo, Shangwen; Qian, Fu-Gang; Guangyi, Xu; Pan, Sheng-Li

doi:10.1080/00021369.1986.10867483

Cited by 5 publications

(9 citation statements)

References 2 publications

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“…Saikosaponin derivatives S26 /'-I S29, S31/'-1 S34 and S36 were extracted from the root part of Bupleurum kunmingense as described in a previous paper 3 ) and purified according to the method summarized in Scheme 1. Their properties are shown in Table I nins were determined to be glucose and fucose by acid hydrolysis followed by TLC analysis, and the terminal sugar was identified as glucose by mass spectroscopic analysis of the trimethylsilyl derivatives.…”

Section: And Discussionmentioning

confidence: 99%

“…400MHz IH-NMR, 100MHz 13C-NMR and FAB-mass spectra were obtained as reported in a previous paper. 3 ) Acid degradation of saponins. Solutions of 1ml of 1N HCI and 1ml of dioxane containing 10 mg of each sample were sealed in ampoules.…”

Section: Honmentioning

confidence: 99%

“…As a result, we isolated five new triterpenoid glycosides from this plant, and determined their chemical structures as reported in a previous paper. 3 ) More recently, we have isolated nine additional new· saikosaponins from the same plant after further work, and have determined their structures based on chemical and spectroscopic analyses as follows: S26, In this paper, we describe the structural elucidation of these new saponin derivatives isolated from Bupleurum kunmingense. RESULTS …”

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confidence: 99%

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Structures of New Saponins Isolated fromBupleurum kunmingenseY. LietS. L. Pan

Seto¹,

Kawai²,

Ōtake³

et al. 1986

Agricultural and Biological Chemistry

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Section: And Discussionmentioning

confidence: 99%

Section: Honmentioning

confidence: 99%

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confidence: 99%

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Structures of New Saponins Isolated fromBupleurum kunmingenseY. LietS. L. Pan

Seto¹,

Kawai²,

Ōtake³

et al. 1986

Agricultural and Biological Chemistry

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“…from B. kunmingense, and determined their chemical structures as reported in a previous paper. 2 ) Described here is an investigation on B. polyclonum.…”

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“…Recently, two of the authors have discovered in Yunnan Province, China, two new species in Bupleurum genus, named B. kunmingense Y. Li et S. L. 'Pan and B. polyclonum Y. Li et S. L. Pan, which are used by local inhabitants as the drug "Chaifu".1) During the course of our studies on saponins contained in Bupleurum plants, 2,3) it turned out that these two new species had much higher saponin contents than the official B. chinense. This finding attracted our attention to make detailed studies on their chemical constituents.…”

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Isolation of Triterpenoid Glycosides (Saikosaponins) fromBupleurum polyclonumY. LietS. L. Pan and Their Chemical Structures

Seto

Ōtake

Kawai

et al. 1986

Agricultural and Biological Chemistry

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Characterization and identification of saikosaponins in crude extracts from three Bupleurum species using LC‐ESI‐MS

Huang

Zhang

Lin

et al. 2008

J of Separation Science

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A LC-diode array detection (DAD)-ESI-MS/MS method was established for the online characterization and identification of saikosaponins (SSs) from extracts of roots of Bupleurum scorzonerifolium Willd, B. marginatum var. stenophyllum and B. komarovianum. In ESI-MS/MS spectra of SSs, [M-H](- )ions were subjected to the cleavage of glycosidic bonds and produced Y type ions, which can be used to elucidate the structures of saccharide chains and aglycones. Fragmentation of aglycones provided mass information about their major substitutions. For three structural types of SSs, type III can be easily identified by their fragmentation behaviors; while type I and II often occur as isomers and they can be discriminated by their typical UV absorption data. The only sugar ring-cross cleavage corresponding to 76 Da took place at a furanose sugar moiety. As a result, more than 75 SSs, including eight novel compounds, were identified or tentatively characterized based on their UV and mass spectra and retention times. The approach established here allows a comprehensive analysis of the SSs in the genus of Bupleurum and will be helpful for quality control of the crude materials and their related preparations.

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Isolation of Triterpenoid Glycosides (Saikosaponins) fromBupleurum kunmingenseand Their Chemical Stmctures

Cited by 5 publications

References 2 publications

Structures of New Saponins Isolated fromBupleurum kunmingenseY. LietS. L. Pan

Structures of New Saponins Isolated fromBupleurum kunmingenseY. LietS. L. Pan

Isolation of Triterpenoid Glycosides (Saikosaponins) fromBupleurum polyclonumY. LietS. L. Pan and Their Chemical Structures

Characterization and identification of saikosaponins in crude extracts from three Bupleurum species using LC‐ESI‐MS

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