Isolation of Two Streptothricin-like Antibiotics, Nos. 6241-A and B, as Inhibitors of <i>de novo</i> Starch Synthesis and Their Herbicidal Activity

Kida, Takao; Ishikawa, Takehiro; Shibai, Hiroshiro

doi:10.1080/00021369.1985.10866968

Cited by 3 publications

(2 citation statements)

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“…RM-5-8 with a very similar structure as compound 186, but there were no reports on the herbicidal activity of them. 186 Compounds A-87774-1 (189), A-87774-2 (190), and A-87774-3 (191) [with molecular weights (MWs) of 668, 666, and 828 Da] were produced by Streptomyces sp. strain SANK 61805.…”

Section: Anthraquinones and Ansamycinsmentioning

confidence: 99%

“…Among the herbicidal compounds produced by actinomycetes, bialaphos, glufosinate, and methoxyphenone have yielded commercial herbicides. Kida et al had established a simple bioassay for the discovery of herbicidal compounds from microorganisms through analysis of de novo starch synthesis in leaf segments . Jiang et al also demonstrated the feasibility of biocombinatorial synthesis of herbicidal thaxtomins. , In combination with new techniques in synthetic biology, the productivity of discoveries has potential to increase exponentially.…”

Section: Prospectsmentioning

confidence: 99%

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Herbicidal Secondary Metabolites from Actinomycetes: Structure Diversity, Modes of Action, and Their Roles in the Development of Herbicides

Shi

Zhang

et al. 2019

J. Agric. Food Chem.

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Weeds had caused significant loss for crop production in the process of agriculture. Herbicides have played an important role in securing crop production. However, the high reliance on herbicides has led to environmental issues as well as the evolution of herbicide resistance. Thus, there is an urgent need for new herbicides with safer toxicological profiles and novel modes of action. Actinomycetes produce very diverse bioactive compounds, of which some show potent biopesticidal activity. The herbicidal secondary metabolites from actinomycetes can be classified into several groups, such as amino acids, peptides, nucleosides, macrolides, lactones, amide, amines, etc., some of which have been successfully developed as commercial herbicides. The structure diversity and evolved biological activity of secondary metabolites from actinomycetes can offer opportunities for the development of both directly used bioherbicides and synthetic herbicides with new target sites, and thus, this review focuses on the structure, herbicidal activity, and modes of action of secondary metabolites from actinomycetes.

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Section: Anthraquinones and Ansamycinsmentioning

confidence: 99%

Section: Prospectsmentioning

confidence: 99%

Herbicidal Secondary Metabolites from Actinomycetes: Structure Diversity, Modes of Action, and Their Roles in the Development of Herbicides

Shi

Zhang

et al. 2019

J. Agric. Food Chem.

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A

Collins¹

1998

Dictionary of Carbohydrates

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Detection of Novel Secondary Metabolites

Franco¹,

Coutinho²

1991

Critical Reviews in Biotechnology

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The study of antibiotics and other fermentation products has shown that a seemingly unlimited number of compounds with diverse structures are produced by microorganisms. The continued high rate of discovery of new chemical entities, in the light of the abundance of microbial products already described, is due to creative screening procedures that incorporate such features as the emphasis on unusual microorgnaisms, their special propagation and fermentation requirements, supersensitive and highly selective assays, genetic engineering both for the biosynthesis of new compounds and in the development of screening systems, early in vivo evaluation, improved isolation techniques, modern procedures for structure determination, computer-assisted identification, and an efficient multidisciplinary approach. This review focuses on the genesis and development of the gamut of methodologies that have led to the successful detection of the wide variety of novel secondary metabolites that include antibacterial, antigungal, antiviral and antitumour antibiotics, enzyme inhibitors, pharmacologically and immunologically active agents, products useful in agriculture and animal husbandry, microbial regulators, and other compounds for which no bioactive role has yet been found.

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Isolation of Two Streptothricin-like Antibiotics, Nos. 6241-A and B, as Inhibitors of de novo Starch Synthesis and Their Herbicidal Activity

Cited by 3 publications

References 4 publications

Herbicidal Secondary Metabolites from Actinomycetes: Structure Diversity, Modes of Action, and Their Roles in the Development of Herbicides

Herbicidal Secondary Metabolites from Actinomycetes: Structure Diversity, Modes of Action, and Their Roles in the Development of Herbicides

A

Detection of Novel Secondary Metabolites

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