Isolation of Virus Related to SV40 from Patients with Progressive Multifocal Leukoencephalopathy

Weiner, Leslie P.; Herndon, Robert M.; Narayan, Opendra; Johnson, Richard T.; Shah, Keerti V.; Rubinstein, Lucien J.; Preziosi, Thomas J.; Conley, Frances K.

doi:10.1056/nejm197202242860801

Cited by 286 publications

(100 citation statements)

References 19 publications

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“…Finally, 14% of people born in those years were not vaccinated at all; however, they were included for analyses because it was not possible to identify them for exclusion (Geissler, 1990). The second group (1962 ± 1964),`most of whom received SV40-free vaccines', included people who received SV40-contaminated vaccines, since these vaccines were distributed until 1963 (Geissler, 1990;Shah and Nathanson, 1976 (Weiner et al, 1972;Soriano et al, 1974;Weiss et al, 1975;Krieg et al, 1981;Walsh et al, 1982;Stoian et al, 1984). However, the limited technology available at that time made it di cult to reproduce the ®ndings and to obtain de®nitive results.…”

Section: Epidemiological Studies: Poliovaccines Sv40 and Human Cancermentioning

confidence: 99%

“…Southern blots with weak bands were published, and the immuno¯uorescence data were questioned because of a possible cross-reaction with Tags from other DNA tumor viruses (i.e., BK and JC viruses). In those instances in which SV40 virus had been recovered from human specimens (Weiner et al, 1972;Soriano et al, 1974;Krieg et al, 1981) the ®ndings were verbally questioned as possible laboratory contamination, even if no evidence of contamination existed. At the NIH conference, Strickler, 1997, reported that the incidence of tumors, including ependymomas, and osteosarcomas has not increased since 1973 when the SEER data became available (SEER, Surveillance Epidemiology and End Results, is a program of the National Cancer Institute to collect data on cancer patients on a routine basis.…”

Section: Epidemiological Studies: Poliovaccines Sv40 and Human Cancermentioning

confidence: 99%

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Simian virus 40, poliovaccines and human tumors: a review of recent developments

1997

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Recently, wild-type SV40 and/or DNA sequences indistinguishable from SV40 have been detected in speci®c types of human tumors: ependymoma and choroid plexus tumors, mesothelioma, osteosarcoma and sarcoma. The same tumor types will develop in hamsters after injection with SV40. These ®ndings are interesting in themselves for they could shed light on the pathogenesis of these tumors. These ®ndings also have public health implications. SV40 was found to have contaminated the poliovaccines and the adenovaccines from 1955 until 1963, therefore resulting in the inadvertent injection of millions of people with this tumor virus. Moreover, our society pays a high cost for asbestos causality, a carcinogen associated with the development of mesothelioma. In addition to asbestos, the potential impact of ®nding another possible cause for mesothelioma (i.e., SV40), as well as the possible pathogenic role of the contaminated poliovaccines, has generated considerable public interest and concern. To discuss these recent ®ndings, the NIH (National Institutes of Health) and the FDA (Food and Drug Administration), organized an International Conference at the NIH, Bethesda, MD, January 27 ± 28, 1997. The association of SV40 with human mesothelioma was also discussed in a special session at the IV International Mesothelioma Conference that was held at the University of Pennsylvania, Philadelphia, PA, May 13 ± 16, 1997. The purpose of this review is to summarize data, from the discovery of the contaminated poliovaccines, to the most recent ®ndings presented at the meetings in Bethesda and Philadelphia, to discuss technical and other problems associated with this research, and the potential for using these ®ndings to develop new diagnostic and therapeutic approaches for SV40-associated malignancies.

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Section: Epidemiological Studies: Poliovaccines Sv40 and Human Cancermentioning

confidence: 99%

Section: Epidemiological Studies: Poliovaccines Sv40 and Human Cancermentioning

confidence: 99%

Simian virus 40, poliovaccines and human tumors: a review of recent developments

1997

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“…Viruses morphologically indistinguishable from papovavirus have been isolated from man [1,5,8,12]. One of these, BK virus, was isolated from a kidney transplant patient [1,5].…”

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confidence: 99%

“…Active infection with BK virus was shown to occur in 38% of patients with such transplants [1]. Furthermore, BK virus antibody was found to be common in humans in England [4], the United States [10][11][12], and Japan (Taguchi et al, unpublished data). Although the potential oncogenicity of BK virus has been demonstrated in vitro [7], the etiological significance of this virus in man remains uncertain.…”

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confidence: 99%

Transplacental Transmission of BK Virus in Human

Taguchi

Nagaki

Saito

et al. 1975

Japanese Journal of Microbiology

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“…Progressive multifocal leukoencephalopathy was felt to be paraneoplastic in the past, but a viral cause was later established. 5 Further characterization and understanding of the paraneoplastic syndromes are important for several reasons. At times the syndrome is the major clinical problem requiring attention, and appropriate palliative management may be important for the quality and duration of patient survival.…”

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confidence: 99%