Isolation ofBordetella bronchiseptica from a patient with AIDS

Mesnard, R.; Guiso, Nicole; Michelet, Christian; Sire, Jean-Marie; Pouëdras, P.; Donnio, Pierre-Yves; Avril, J

doi:10.1007/bf01967267

Cited by 22 publications

(14 citation statements)

References 10 publications

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“…These range from acute iatrogenic maxillary sinusitis and tracheobronchitis to acute pneumonia and pneumonia with septicemia. This organism is typically a pathogen of immunocompromised hosts such as people who abuse alcohol, people with diabetes, patients with Hodgkin's disease or chronic lymphocytic leukemia and patients with HIV/AIDS [6]. …”

Section: Discussionmentioning

confidence: 99%

Bordetella bronchiseptica pneumonia in a man with acquired immunodeficiency syndrome: a case report

Galeziok

Passalacqua

2009

J Med Case Reports

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IntroductionBordetella bronchiseptica can be a cause of virulent pneumonia in humans with impaired immune systems. Few cases have been reported in the medical literature where Bordetella bronchiseptica has been the only pathogen isolated during a course of interstitial pneumonia.Case presentationA 42-year-old African-American man with human immunodeficiency virus presented with pulmonary symptoms that mimicked Pneumocystis jiroveci pneumonia. A sputum culture grew Bordetella brochiseptica, a common respiratory commensal of wild and domestic animals, rarely implicated in human infections.ConclusionBordetella bronchiseptica should be added to the differential list of pathogens which can affect people with human immunodeficiency virus and pulmonary symptoms. Sputum culture, as well as history of animal exposure, in these patients is advised.

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Section: Discussionmentioning

confidence: 99%

Bordetella bronchiseptica pneumonia in a man with acquired immunodeficiency syndrome: a case report

Galeziok

Passalacqua

2009

J Med Case Reports

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“…We found 11 reports in the English-language literature describing the isolation of B. bronchiseptica from 15 cases of infectious processes affecting AIDS patients (3,6,12,13,14,17,20,23,24,26,32). The patients are usually in an advanced stage of HIV infection and in some cases have had contact with pets.…”

Section: Discussionmentioning

confidence: 99%

“…Treatment duration is also a controversial issue. It varies from 2 to 4 weeks for patients with a good response (3,12,13,20,23,32) to 6 months for patients with recurrent symptoms (24). The increasing rate of isolation of B. bronchiseptica from AIDS patients with pneumonia emphasizes its importance as an opportunistic pathogen and guarantees the consideration of B. bronchiseptica as a potential etiological agent of pneumonia with or without lung cavitation in AIDS patients.…”

Section: Discussionmentioning

confidence: 99%

“…For the last epidemiological group, isolation of B. bronchiseptica from the respiratory tract (3,6,12,13,14,17,20,23,24,32) or from the blood (26) of human immunodeficiency virus (HIV)-infected patients with respiratory diseases has been increasingly reported. This circumstance has prompted some investigators to propose the inclusion of B. bronchiseptica in the list of opportunistic pathogens causing diseases associated with exposure of HIV-infected patients to animals (20,32).…”

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confidence: 99%

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Cavitary Pneumonia in an AIDS Patient Caused by an Unusual Bordetella bronchiseptica Variant Producing Reduced Amounts of Pertactin and Other Major Antigens

Lorenzo-Pajuelo

Villanueva²,

Rodríguez-Cuesta

et al. 2002

J Clin Microbiol

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Although Bordetella bronchiseptica can infect and colonize immunocompromised humans, its role as a primary pathogen in pneumonia and other respiratory processes affecting those patients remains controversial. A case of cavitary pneumonia caused by B. bronchiseptica in an AIDS patient is presented, and the basis of the seemingly enhanced pathogenic potential of this isolate (designated 814) is investigated. B. bronchiseptica was the only microorganism recovered from sputum, bronchoalveolar lavage fluid, and samples taken through the protected brush catheter. Unlike previous work reporting the involvement of B. bronchiseptica in cases of pneumonia, antibiotic treatment selected on the basis of in vitro antibacterial activity resulted in clearance of the infection and resolution of the pulmonary infiltrate. Although isolate 814 produced reduced amounts of several major antigens including at least one Bvg-activated factor (pertactin), the molecular basis of this deficiency was found to be BvgAS independent since the defect persisted after the bvgAS locus of isolate 814 was replaced with a wild-type bvgAS allele. Despite its prominent phenotype, isolate 814 displayed only a modest yet a significant deficiency in its ability to colonize the respiratory tracts of immunocompetent rats at an early time point. Interestingly, the antibody response elicited by isolate 814 in these animals was almost undetectable. We propose that isolate 814 may be more virulent in immunocompromised patients due, at least in part, to its innate ability to produce low amounts of immunogenic factors which may be required at only normal levels for the interaction of this pathogen with its immunocompetent natural hosts.

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“…Bordetella bronchiseptica, a Gram-negative bacterium, has been isolated from many animal species and may be responsible for respiratory disease in mammals [1][2][3]. It may also colonize the human respiratory tract and cause disease in compromised hosts [2,[4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Intranasal Inoculation of Bordetella Bronchiseptica in Mice Induces Long‐Lasting Antibody and T‐Cell Mediated Immune Responses

Gueirard¹,

Minóprio

Guiso³

1996

Scand J Immunol

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Humoral and cellular immune responses were analysed in mice inoculated intranasally with Bordetella bronchiseptica. After infection, the number of bacteria that colonized the respiratory tract of the mice increased during the first day and decreased thereafter. Total IgG levels increased as early as 14 days after infection and decreased with time after infection, whereas total IgA and IgM levels were lower but remained stable. Specific antibodies to the bacteria were mainly IgG2a and IgA and persisted up to 10 months after infection. Some of these specific antibodies were directed against adenylate cyclase-haemolysin, the bacterial factor that had been shown to be necessary for initiation of infection. The proliferation of Bordetella bronchiseptica-reactive spleen cells occurred during the acute phase of infection. T cells from infected mice produced increasing amounts of IFN gamma and IL-2 after infection. Although very low levels of IL-10 were produced, no IL-4 was detected after bacterial stimulation in vitro. These results suggest that Bordetella bronchiseptica infection induces primarily a Th1-type T-cell response. Importantly, the authors demonstrated that antibody and T-cell responses directed against bacterial determinants of the virulent strain and to purified adenylate cyclase-haemolysin were long-lasting. This observation could be due to the fact that Bordetella bronchiseptica may persist intracellularly in the host as it was demonstrated in vitro.

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Isolation ofBordetella bronchiseptica from a patient with AIDS

Cited by 22 publications

References 10 publications

Bordetella bronchiseptica pneumonia in a man with acquired immunodeficiency syndrome: a case report

Bordetella bronchiseptica pneumonia in a man with acquired immunodeficiency syndrome: a case report

Cavitary Pneumonia in an AIDS Patient Caused by an Unusual Bordetella bronchiseptica Variant Producing Reduced Amounts of Pertactin and Other Major Antigens

Intranasal Inoculation of Bordetella Bronchiseptica in Mice Induces Long‐Lasting Antibody and T‐Cell Mediated Immune Responses

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