Isolation Perfusion for Malignant Melanomas: Established Facts and Parameters to Be Clarified

Hohenberger, Werner

doi:10.1007/978-3-642-74818-9_30

Cited by 6 publications

(2 citation statements)

References 11 publications

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“…Achieving a complete response is of great importance, above all in cases of nonresectable intransit metastases, because local tumor relapse and progression of disease is less probable in comparison to only a partial response. It seems crucial to notice that a complete remission can only be stated if there is measurable tumor growth at the extremity that has not been excised before or during the perfusion procedure so that the effect can be observed directly and/or proven histologically by excision a few weeks after perfusion [7,12]. Adhering to these principles, this was possible in 41 stage IIIA patients of the first group (n =163) with observed complete remissions in 20 of them (49%), which was of longstanding duration in 12 cases (12/20 = 60%).…”

Section: Discussionmentioning

confidence: 99%

“…The interval between treatment of the primary tumor and perfusional therapy amounted to a median of 25 months (range 3-159 months). Prospectively gathered data about remission rates of 41 patients with intransit metastases out of this collective had been registered and published in the past [7]. 20 out of these 41 cases (49%) were reported to receive a complete remission.…”

Section: Group Imentioning

confidence: 99%

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Hyperthermic Isolated Limb Perfusion – 23 Years’ Experience and Improvement of Results by Modification of Technique

Meyer¹,

Göhl²,

Haas³

et al. 1998

Oncol Res Treat

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Section: Discussionmentioning

confidence: 99%

Section: Group Imentioning

confidence: 99%

Hyperthermic Isolated Limb Perfusion – 23 Years’ Experience and Improvement of Results by Modification of Technique

Meyer¹,

Göhl²,

Haas³

et al. 1998

Oncol Res Treat

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Thirty-five years of isolated limb perfusion for melanoma: Indications and results

Vrouenraets

Nieweg

Kroon

1996

Journal of British Surgery

108

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Isolated limb perfusion (ILP) for limb melanoma remains controversial despite its frequent use for over 35 years. To determine whether it has proven benefits, reported results have been reviewed. The value of adjuvant ILP cannot be determined from the multitude of retrospective studies on this subject. Preliminary results of the large European Organization for Research and Treatment of Cancer-World Health Organization-North American Perfusion Group trial suggest that patients with melanomas of 1.5-3.0 mm in thickness who do not undergo elective lymph node dissection may have a locoregional control benefit from ILP. However, as long as a definite survival advantage for ILP has not been demonstrated, such treatment does not seem justified for these patients. The value of prophylactic ILP after resection of recurrent limb melanoma is also scientifically unproven. The potential prevention of further limb recurrence for only a limited period of time, as demonstrated in a rather small Swedish trial, probably does not justify routine use of ILP in these patients; a large international trial will be needed to assess whether ILP provides a survival advantage. For those with locally inoperable limb melanoma, ILP appears to be the treatment of choice since it results in complete disappearance of all macroscopic disease in a substantial proportion of patients, removing the need for amputation and providing palliation of symptoms. However, high limb recurrence rates and short duration of response need improvement. Results of alternative treatments should be compared prospectively with those of ILP in this clinical situation.

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Chirurgische Indikationen und technisches Vorgehen bei Organmetastasen

Kremer

Saeger²,

Hohenberger³

et al. 1995

Qualitätssicherung Durch Zusammenarbeit in Der Chirurgie

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Isolation Perfusion for Malignant Melanomas: Established Facts and Parameters to Be Clarified

Cited by 6 publications

References 11 publications

Hyperthermic Isolated Limb Perfusion – 23 Years’ Experience and Improvement of Results by Modification of Technique

Hyperthermic Isolated Limb Perfusion – 23 Years’ Experience and Improvement of Results by Modification of Technique

Thirty-five years of isolated limb perfusion for melanoma: Indications and results

Chirurgische Indikationen und technisches Vorgehen bei Organmetastasen

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