Isolation, structure elucidation, tyrosinase inhibitory, and antioxidant evaluation of the constituents from Angelica dahurica roots

Shu, Penghua; Li, Junping; Fei, Yingying; Zhu, Huiqing; Yu, Mengzhu; Liu, Anqi; Niu, Haoying; Chen, Xianping; Wei, Xialan; Ju, Zhiyu; Xu, Zheng

doi:10.1007/s11418-019-01375-8

Cited by 25 publications

(23 citation statements)

References 32 publications

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“…Compound 17 , was a previously reported compound possessing a 3,4‐diphenol moiety, and it exhibited obvious DPPH radical scavenging activity [28] . The introduction of sugar fragments in a compound can enhance the free radical scavenging activity, [29] and therefore, compounds 1 – 8 exhibited stronger DPPH radical‐scavenging activity than compounds 9 – 16 . As previously reported, the carboxy groups on the aromatic ring in compound 18 may be responsible for its stronger activity [27] .…”

Section: Resultsmentioning

confidence: 99%

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New Phenylpropanoid Glycosides from Illicium majus and Their Radical Scavenging Activities

Yan

et al. 2021

Chemistry & Biodiversity

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Chemical investigation of the ethanol extract of the branch and leaves of Illicium majus resulted in the isolation of four new phenylpropanoid glycosides (1–4) and one new phenolic glycoside (9), along with 13 known ones. Spectroscopic techniques were used to elucidate the structures of the new isolates such as 3‐[(2R,3S)‐7‐hydroxy‐2‐(4‐hydroxy‐3‐methoxyphenyl)‐3‐(hydroxymethyl)‐2,3‐dihydro‐1‐benzofuran‐5‐yl]propyl β‐D‐glucopyranoside (1), [(2R,3S)‐7‐hydroxy‐2‐(4‐hydroxy‐3‐methoxyphenyl)‐5‐(3‐hydroxypropyl)‐2,3‐dihydro‐1‐benzofuran‐3‐yl]methyl 2‐O‐α‐L‐rhamnopyranosyl‐β‐D‐glucopyranoside (2), [(2R,3S)‐7‐hydroxy‐2‐(4‐hydroxy‐3‐methoxyphenyl)‐5‐(3‐hydroxypropyl)‐2,3‐dihydro‐1‐benzofuran‐3‐yl]methyl 2‐O‐α‐L‐rhamnopyranosyl‐β‐D‐xylopyranoside (3), 3‐[(2R,3S)‐3‐({[2‐O‐(4‐O‐acetyl‐α‐L‐rhamnopyranosyl)‐β‐D‐xylopyranosyl]oxy}methyl)‐7‐hydroxy‐2‐(4‐hydroxy‐3‐methoxyphenyl)‐2,3‐dihydro‐1‐benzofuran‐5‐yl]propyl acetate (4), and 4‐(2‐hydroxyethyl)phenyl 3‐O‐β‐D‐glucopyranosyl‐β‐D‐glucopyranoside (9). Free radical scavenging activities of the isolates were elucidated through the DPPH assay method. The most active compounds, 1‐O‐caffeoyl‐β‐D‐glucopyranose (17) and soulieana acid 1 (18), exhibited moderate radical scavenging activities (IC50=37.7±4.4 μM and IC50=97.2±3.4 μM, respectively). The antibacterial activities of the isolates against Staphylococcus aureus and Escherichia coli were also assessed, and no activity was shown at the measured concentration (<32 μg/mL).

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Section: Resultsmentioning

confidence: 99%

“…The DPPH radical scavenging evaluation was carried out on the basis of the reported literature [29] . Briefly, 20 μL of each compound solution [in dimethyl sulfoxide (DMSO)] at 0.16 mM concentrations was mixed with 180 μL of 0.1 mM DPPH methanol solution in a 96‐well microplate.…”

Section: Methodsmentioning

confidence: 99%

New Phenylpropanoid Glycosides from Illicium majus and Their Radical Scavenging Activities

Yan

et al. 2021

Chemistry & Biodiversity

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“…Nevertheless, most of the previous studies are only focused on the chemical profiling or quantification of several coumarin constituents in BZ. 6,13 Moreover, compared with the amount of research regarding the chemical analysis of BZ, reports on HBZ are relatively few. To the best of our knowledge, no study has been conducted to systematically characterise and compare the chemical profiles of the contents of the main bioactive coumarins in BZ and HBZ, and no chemometric analysis has been employed to compare and distinguish these two sources of Angelicae dahuricae Radix.…”

Section: Discussionmentioning

confidence: 99%

“…In total, eleven disubstituting LFCs, including neobyakangelicol (6), xanthotoxol (7), 5-methoxy-8-hydroxy psoralen (12), isopimpinellin (13), apaensin (15), byakangelicol (17), phellopterin (20), 5-hydroxy xanthotoxin (21), cnidilin (22), isobyakangelicol (28) and cnidicin (29), were identified.…”

Section: Ms/ms Spectrum Presented Fragment Ions Atmentioning

confidence: 99%

“…Angelicae dahuricae Radix is also an important spice, which is used to increase the aroma and remove the unpleasant odour in many foods 2 . Pharmacological investigations disclosed that Angelicae dahuricae Radix possesses various activities, such as antiallergic inflammatory, antioxidant, antianaphylactic, analgesic, anticancer and tyrosinase inhibitory activities 3–6 . According to the Chinese Pharmacopoeia and the Korean Pharmacopoeia, Angelica dahurica (Fisch.…”

Section: Introductionmentioning

confidence: 99%

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Chemical comparison and discrimination of two plant sources of Angelicae dahuricae Radix, Angelica dahurica and Angelica dahurica var. formosana, by HPLC‐Q/TOF‐MS and quantitative analysis of multiple components by a single marker

Shi

Chang

Xie

et al. 2022

Phytochemical Analysis

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Introduction Angelica dahurica(BZ) and Angelica dahurica var. formosana(HBZ) are two plant sources of Angelicae dahuricae Radix. Although BZ and HBZ are commonly used herbal medicines with great medicinal and dietary values, study on their phytochemicals and bioactive compositions is limited. Objective To compare the chemical compositions of BZ and HBZ and find the chemical makers for discrimination and quality evaluation of the two botanical origins of Angelicae dahuricae Radix. Methodology A high‐performance liquid chromatography coupled with quadrupole time‐of‐flight mass spectrometry method was established for chemical profiling of BZ and HBZ. Then, a quantitative analysis of multiple components by a single marker method was developed for simultaneous determination of nine bioactive coumarins (xanthotoxol, oxypeucedanin hydrate, byakangelicin, xanthotoxin, bergapten, oxypeucedanin, phellopterin, imperatorin and isoimperatorin). Moreover, chemometrics were performed to compare and discriminate BZ and HBZ samples. Results A total of 30 coumarins compounds were identified, and the chemical compositions in BZ and HBZ were quite similar. The quantitative analysis showed that there were significant differences in the contents of bioactive coumarins, and the chemometric analysis indicated five coumarins (xanthotoxol, xanthotoxin, bergapten, phellopterin and isoimperatorin) were responsible for the significant differences between BZ and HBZ, which could be used as chemical markers to distinguish the two original plant sources of Angelicae dahuricae Radix. Conclusion The present work provided useful information for understanding the chemical differences between BZ and HBZ and also provided feasible methods for quality evaluation and discrimination of herbal medicines originating from multiple botanical sources.

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Fabrication of hyaluronic acid‐based nanoparticles and studies on their radical scavenging activity

Zhu,

Xu,

Shang

et al. 2024

Polymers for Advanced Techs

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The purpose of this paper is to study the stability, radical scavenging activities, and bio‐safety of cysteine‐conjugated hyaluronic acid nanoparticles (Cys‐conj‐HA NPs). Additionally, the feasibility of utilizing these NPs as drug delivery systems is discussed. The structures of synthesized Cys‐conj‐HA polymers were analyzed using 1H nuclear magnetic spectrum (1H NMR) and Fourier transform infrared spectroscopy (FTIR) spectra. The stability, radical scavenging activity, and bio‐safety of fabricated Cys‐conj‐HA NPs were investigated. Transmission electron microscopy (TEM) photograph illustrated that Cys‐conj‐HA NPs possessed spherical shapes with an average diameter of approximately 230 nm. Furthermore, these NPs exhibited high stability at temperatures of 4, 25, and 37°C. Notably, Cys‐conj‐HA NPs demonstrated significant free radical scavenging capabilities. The high cell viability observed indicated the absence of cytotoxicity from Cys‐conj‐HA NPs. Additionally, bio‐safety studies revealed that these NPs did not induce acute toxicity in the blood and viscera of cargo‐free NPs treated mice. Elisa assays indicated that there was no significant difference in the concentrations of interferon‐γ (INF‐γ) and tumor necrosis factor‐α (TNF‐α) between Cys‐conj‐HA NPs and normal saline (NS) treated mice (ns, p > 0.05), suggesting the absence of an inflammatory reaction caused by these NPs. Consequently, it can be concluded that Cys‐conj‐HA NPs are sufficiently safe to be employed as a vehicle for delivering oxidizing drugs.

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Isolation, structure elucidation, tyrosinase inhibitory, and antioxidant evaluation of the constituents from Angelica dahurica roots

Cited by 25 publications

References 32 publications

New Phenylpropanoid Glycosides from Illicium majus and Their Radical Scavenging Activities

New Phenylpropanoid Glycosides from Illicium majus and Their Radical Scavenging Activities

Chemical comparison and discrimination of two plant sources of Angelicae dahuricae Radix, Angelica dahurica and Angelica dahurica var. formosana, by HPLC‐Q/TOF‐MS and quantitative analysis of multiple components by a single marker

Fabrication of hyaluronic acid‐based nanoparticles and studies on their radical scavenging activity

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