Isolement par partition bio guidé du principe actif myostimulant de l’extrait aqueux de &lt;i&gt;Mareya micrantha&lt;/i&gt; (Benth) Mull. Arg. (Euphorbiaceae)

Dosso, M; Soro, Doudjo; Koffi, A.; Traoré, Flavien; N’Guessan, Jean David

doi:10.4314/jab.v114i1.7

Cited by 3 publications

(1 citation statement)

References 3 publications

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“…Müll.Arg (Ephorbiaceae) est une plante utilisée en médicine traditionnelle à des fins purgatives, laxatives, et contre la diarrhée et le téniasis (Dosso et al, 2013). Les évaluations biologiques réalisées sur cette plante ont montré qu'elle a des propriétés myoactive (Doumbia et al, 2014 ;Dosso et al, 2017) et antimicrobienne (Zihiri et al, 2006).…”

Section: Introductionunclassified

Activité antibactérienne et Constituants chimiques des feuilles de <i>Mareya micrantha</i> (Euphorbiaceae)

Okpekon,

Koffi,

Bony

et al. 2023

Int. J. Bio. Chem. Sci

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Mareya micrantha (Euphorbiaceae) est une plante médicinale Ivoirienne utilisée contre la diarrhée, la toux, le téniasis et aussi à des fins laxatives et abortives. L’objectif de cette étude est de déterminer les principes antibactériens contenus dans ses feuilles. Ainsi, lesfeuilles,séchées et broyées, ont été macérées dans de l’éthanol pour constituer l’extrait brut éthanolique (FE) qui après contre- extraction a conduit aux sous-extraits hexanique (FEH), chlorométhylénique (FED), acétatique (FEA), butanolique (FEB) et aqueux résiduel (FEAr). Ces différents extraits ont été évalués sur certaines bactéries responsables d’affections entériques. L’extrait brut FE et ses sous-extraits FED et FEA ne s’étaient montrés plus actifs que sur Salmonella bongori et Staphylococcus aureus (diamètres d’inhibition de 12,20 ± 0,80 à 17,10 ± 0,90 mm). Les dérivés de nor-curcubitacine (C1) et de kaempférol (C4), déterminés grâce à leurs données spectrales (SM, IR, UV, RMN 1D et 2D), sont les principes antibactériens des feuilles de la plante contre Salmonella bongori et Staphylococcus aureus. Les CMI (320 µg/mL à 730 µg/mL) et CMB (400 µg/mL à 850 µg/mL) mesurées pour ces composés montrent qu’ils exercent une action bactéricide. Ces données pourraient permettre de justifier l’utilisation en médecine traditionnelle des feuilles contre les infections entériques. English title: Antibacterial activity and Chemical constituents from Mareya micrantha (Euphorbiaceae) Mareya micrantha (Euphorbiaceae) is an Ivorian medicinal plant used against diarrhea, cough, tapeworm and also for laxative and abortive purposes. The aim of this study is to determine the antibacterial principles presented in its leaves. Thus, the leaves, dried and ground, were macerated in ethanol to constitute the crude ethanolic extract (FE) which after counter-extraction led to the hexane (FEH), chloromethylene (FED), ethyl acetate (FEA), butanol (FEB) and residual aqueous (FEAr) sub-extract. These different extracts were evaluated on certain bacteria responsible for enteric diseases. The FE crude extract and its FED and FEA sub-extracts were only shown to be more active on Salmonella bongori and Staphylococcus aureus (inhibition diameters from 12.20 ± 0.80 to 17.10 ± 0.90 mm). Nor- curcubitacin (C1) and kaempferol (C4) derivatives, determined using their spectral data (MS, IR, UV, 1D and 2D NMR), are the antibacterial principles of the leaves of the plant against Salmonella bongori and Staphylococcus aureus. The MICs (320 µg/mL to 730 µg/mL) and MBCs (400 µg/mL to 850 µg/mL) measured for these compounds show that they exert a bactericidal action. These data could justify the use in traditional medicine of the leaves against enteric infections.

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Section: Introductionunclassified

Activité antibactérienne et Constituants chimiques des feuilles de <i>Mareya micrantha</i> (Euphorbiaceae)

Okpekon,

Koffi,

Bony

et al. 2023

Int. J. Bio. Chem. Sci

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Liver cancer antiproliferative activity of a new nor-cucurbitacin from Mareya micrantha Müll. Arg.

et al. 2023

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Study of the antioxidant potential, polyphenol content, and mineral composition of Cordyla pinnata, a plant for food and medicinal use of the Senegalese pharmacopoeia

et al. 2022

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Oxidative stress, caused by reactive oxygen species, is known to cause oxidation of biomolecules, leading to cell damage and oxidation of important enzymes, resulting in an unstable pathophysiological state. The antioxidant capacity of leaves, stems, and roots of Cordyla pinnata was determined by measuring the inhibition of the absorbance of 2,2-diphenyl-1-picryl-hydrazyl (DPPH) and 2,2'-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radicals by spectrophotometry. The polyphenol contents were determined with the same technique. The mineral contents were evaluated by atomic absorption spectrometry. The strongest inhibition of the DPPH radical after that of the control antioxidant (IC50 = 0.014 mg/mL) was obtained with the ethyl acetate fraction of the leaf hydroethanolic extract (IC50 = 0.201 mg/mL). For ABTS, the ethyl acetate fraction of the stem extract was more active (IC50 = 0.884×10-3 mg/mL) than the other extracts and ascorbic acid (IC50 = 0.915×10-3 mg/mL). The polyphenol content of the leaves, stems and roots extracts is between 66.33 and 142.67; 55.33 and 69.33; 67.67 and 116.00 EAT/g of dry extract, respectively. The contents of Fe, Na, Zn, K, Mg, and Ca are 0.0005, 0.0006, 0.0020, 0.0897, 0.0247, and 0.0273% for leaves, respectively. They are 0.0001, 0.0010, 0.0015, 0.0557, 0.0131, and 0.1357% for the stems, respectively. The mineral contents of the roots in the same order are 0.0002, 0.0013, 0.0013, 0.0140, 0.0096, and 0.0267%. Strong inhibition of free radicals and the chemical composition of various plant materials would justify the use of C. pinnata in the management of certain pathologies and nutritional deficiencies.

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Isolement par partition bio guidé du principe actif myostimulant de l’extrait aqueux de <i>Mareya micrantha</i> (Benth) Mull. Arg. (Euphorbiaceae)

Cited by 3 publications

References 3 publications

Activité antibactérienne et Constituants chimiques des feuilles de <i>Mareya micrantha</i> (Euphorbiaceae)

Activité antibactérienne et Constituants chimiques des feuilles de <i>Mareya micrantha</i> (Euphorbiaceae)

Liver cancer antiproliferative activity of a new nor-cucurbitacin from Mareya micrantha Müll. Arg.

Study of the antioxidant potential, polyphenol content, and mineral composition of Cordyla pinnata, a plant for food and medicinal use of the Senegalese pharmacopoeia

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