Isoliquiritigenin ameliorates paroxetine-induced sexual dysfunction in male albino mice

Saikia, Queen; Hazarika, Ajit; Kalita, Jatin

doi:10.1016/j.reprotox.2023.108341

Cited by 6 publications

(3 citation statements)

References 79 publications

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“…In this work, UPLC-MS detected nine triterpenoids with a high content from PGE, mainly oleanolic acid saponins. After taking PRX, the gonad function of male mice decreased, mainly manifested as decreased sex hormone levels, testicular tissue structure damage, testicular marker enzyme activity, and sperm quality, which is similar to the results of EL-Gaafarawi et al [68] Saikia Q [8], and Yakubu et al [61]. However, after the PGE treatment, the sex hormone levels and testicular tissue structure of mice were effectively improved, which may be related to the oleanolic acid saponins contained in it, which is similar to the results reported in previous studies.…”

Section: Discussionsupporting

confidence: 84%

“…As shown in Figure 8, compared with the CN group, the sperm count and sperm motility of the PRX group were significantly decreased (p < 0.001), while PGE administration significantly improved the sperm count and sperm motility (p < 0.001, p < 0.01, and p < 0.05). In addition, as shown in Figure 9, PRX administration also led to abnormal sperm in male mice, such as coiled tails, curved tails, annular tails, headless, and double heads (see Figure 9b), consistent with the results of Saikia Q et al [8]. It can be seen that PRX not only causes ED in male mice, but also has an adverse effect on sperm quality in mice.…”

Section: Effects Of Pfaffia Glomerata On Sperm Count and Viabilitysupporting

confidence: 88%

“…Many studies have shown that the continuous use of PRX can lead to ED, decreased libido, and abnormal ejaculation [6]. Therefore, PRX is usually used as a modeling drug to establish a sexual dysfunction model of rodents to evaluate the improvement in sexual dysfunction by plants [7,8]. However, the commonly used drug PDE5 inhibitor for the treatment of sexual dysfunction, sildenafil (SDF), may cause a series of side effects, such as headache, abdominal pain, vomiting, facial congestion, and indigestion [9].…”

Section: Introductionmentioning

confidence: 99%

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Extract of Pfaffia glomerata Ameliorates Paroxetine-Induced Sexual Dysfunction in Male Mice and the Characterization of Its Phytoconstituents by UPLC-MS

Huang,

Wu,

Qin

2023

Foods

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Pfaffia glomerata extract (PGE) has a variety of biological activities. However, its ameliorative effect on and exact working mechanism in male sexual dysfunction are still poorly understood. This study aims to evaluate the ameliorative effect of PGE on paroxetine (PRX)-induced sexual dysfunction in male mice and uses molecular docking technology to investigate its underlying mechanism. In this work, PRX-induced sexual dysfunction was caused and PGE was gavaged in mice for 28 days. The results show that PGE significantly improved the sexual performance of mice and reduced the damage to testicular tissues. Further studies showed that PGE restored serum sex hormones to normal levels and increased nitric oxide (NO) and cyclic guanosine monophosphate (cGMP) levels as well as nitric oxide synthase (NOS) activity in penile tissues, while also decreasing phosphodiesterase-5 (PDE-5) activity, thereby maintaining normal penile erection in mice. In addition, PGE improved the activities of enzymes (LDH, ACP, and ALP) related to energy metabolism in the testis and significantly increased sperm count and viability in mice. Furthermore, the molecular docking results show that all eight compounds in PGE could form a stable complex with PDE-5 and inhibit the activity of PDE-5. In conclusion, PGE had an ameliorative effect on PRX-induced sexual dysfunction, suggesting that PGE has a potential protective effect on male sexual health.

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Section: Discussionsupporting

confidence: 84%

Section: Effects Of Pfaffia Glomerata On Sperm Count and Viabilitysupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

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Extract of Pfaffia glomerata Ameliorates Paroxetine-Induced Sexual Dysfunction in Male Mice and the Characterization of Its Phytoconstituents by UPLC-MS

Huang,

Wu,

Qin

2023

Foods

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Preparation of oyster peptide and Pfaffia glomerata pressed candy and its ameliorative effect on sexual dysfunction in male mice

Huang,

Wu,

Xiao

et al. 2024

Food Science & Nutrition

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Oyster peptide (OP) and Pfaffia glomerata extract (PGE) were used as raw materials. The optimal formulation of the pressed candy (PC) was optimized by one‐way experiment and D‐optimal mixture experiment design, and animal experiment was used to evaluate the effect of PC on male sexual dysfunction. The results showed that PC intervention significantly improved the sexual behavior of male mice with sexual dysfunction, including a significant shortening of the mount latency (ML) and intromission latency, and a significant increase in the mount frequency (MF) and intromission frequency (IF). At the same time, the concentrations of serum testosterone (T) and luteinizing hormone (LH) in mice were restored, and the erectile parameters and pathological changes of penile tissue were improved. Further studies found that PC intervention increased the activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH‐Px) and reduced the content of malondialdehyde (MDA) in testicular tissue. In addition, PC intervention improved testicular tissue morphology. In conclusion, the obtained PC has good taste quality, and the relevant quality indicators are qualified. It has a good ameliorative effect on male sexual dysfunction and may be a potential dietary supplement.

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Assessment of reproductive, genotoxic, and cytotoxic effects of leachate-contaminated water in male mice

Kakati,

Adhikari,

Saikia

et al. 2024

Heliyon

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Isoliquiritigenin ameliorates paroxetine-induced sexual dysfunction in male albino mice

Cited by 6 publications

References 79 publications

Extract of Pfaffia glomerata Ameliorates Paroxetine-Induced Sexual Dysfunction in Male Mice and the Characterization of Its Phytoconstituents by UPLC-MS

Extract of Pfaffia glomerata Ameliorates Paroxetine-Induced Sexual Dysfunction in Male Mice and the Characterization of Its Phytoconstituents by UPLC-MS

Preparation of oyster peptide and Pfaffia glomerata pressed candy and its ameliorative effect on sexual dysfunction in male mice

Assessment of reproductive, genotoxic, and cytotoxic effects of leachate-contaminated water in male mice

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