Isoliquiritigenin inhibits circ0030018 to suppress glioma tumorigenesis via the miR‐1236/HER2 signaling pathway

Abstract

In the central nervous system diseases, glioma is one of the most common malignancies around the world. Despite the recent improvements in therapies for glioma, the prognosis of some high-risk glioma remains poor. In glioma, isoliquiritigenin (ISL) is reported to have antioxidative and antitumor activities. However, the potential mechanisms between ISL and circle RNAs (circRNAs) in the glioma tumorigenesis process have not yet been reported.Here, we treated glioma cells with ISL, and circRNA expression levels were detected. Circ0030018 was found significantly downregulated by ISL. Therefore, we explored circ0030018 expression profiles and functions in glioma, finding that circ0030018 was evidently overexpressed in glioma cell lines. Colony formation, CCK-8, and transwell assay made clear that circ0030018 silencing dramatically cut down glioma growth and invasion. Moreover, ROS level was detected to find that circ0030018 silence remarkably enhanced cell oxidative stress in glioma. Mechanism studies were conducted to investigate the underlying basis of circ0030018 function in glioma, unveiling that circ0030018 realized its functions partially through the miR-1236/HER2 signaling in glioma. In conclusion, our study investigated the roles and mechanisms of the ISL on the circ0030018/miR-1236/HER2 pathway in glioma tumorigenesis and progression.

The prognostic and immunological role of MCM3 in pan-cancer and validation of prognosis in a clinical lower-grade glioma cohort

“…Our single-cell and GSEA analyses showed that MCM3 was closely linked to EMT, which to some extent explained the poor prognosis of LGG patients caused by MCM3 overexpression. In addition, previous studies have demonstrated that essential nodes in crucial pathways may be specifically blocked to slow glioma progression, which further suggests that MCM3 may be a promising therapeutic target for LGG ( Tang et al, 2014 ; Liu et al, 2023 ). In our clinical cohort, MCM3 expression was correlated with the clinical features and prognosis of patients with LGG.…”

CircRNA‐associated ceRNA regulatory networks as emerging mechanisms governing the development and biophysiopathology of epilepsy

“…Among these mechanisms, small noncoding RNAs (ncRNAs) measuring [20][21][22][23][24] base pairs, such as miRNA, have been extensively investigated and are recognized as the most thoroughly studied regulators of gene expression in various diseases. [12][13][14][15][16][17] Recent research suggests that circRNA modulates gene expression more precisely than other types of ncR-NAs. 18,19 Typically, circRNAs can join forces with RNA-binding proteins (RBPs) (Figure 1) to form protein complexes that control the transcriptional and parental linear genes' post-transcriptional expression.…”

“…Numerous epigenetic regulatory mechanisms effectively govern the genes implicated in epileptogenesis, and their enduring alteration in the hippocampus may exert a substantial influence on TLE. Among these mechanisms, small noncoding RNAs (ncRNAs) measuring 20–24 base pairs, such as miRNA, have been extensively investigated and are recognized as the most thoroughly studied regulators of gene expression in various diseases 12–17 . Recent research suggests that circRNA modulates gene expression more precisely than other types of ncRNAs 18,19 .…”

Long non-coding RNAs and JAK/STAT signaling pathway regulation in colorectal cancer development

“…In recent years, there has been a growing body of research that has shed light on the significant contribution of non-coding RNAs to the pathogenesis of different types of cancers ( Wu J. et al, 2022 ; Gao et al, 2022 ; Liu et al, 2023 ; Xie et al, 2023 ). Specifically, lncRNAs and the JAK-STAT pathway have emerged as pivotal factors in the initiation and advancement of CRC ( Li B. et al, 2022 ).…”